5khj - Revision history

OCA at 10:01, 27 September 2023

OCA — Wed, 27 Sep 2023 10:01:00 GMT

←Older revision		Revision as of 10:01, 27 September 2023
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	<StructureSection load='5khj' size='340' side='right'caption='[[5khj]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='5khj' size='340' side='right'caption='[[5khj]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6SY:URIDINE~~-3,~~5-CYCLIC+MONOPHOSPHATE'>6SY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5khg\|5khg]], [[5khh\|5khh]], [[5khi\|5khi]], [[5khk\|5khk]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Hcn2, Bcng2, Hac1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [https://pdbe.org/5khj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [https://www.ebi.ac.uk/pdbsum/5khj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [~~http~~://pdbe.org/5khj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5khj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>	+	[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Accili~~, E A~~]]	+	[[Category: Accili EA]]
-	[[Category: Baronas, V]]	+	[[Category: Baronas V]]
-	[[Category: Ng~~, L C.T]]~~	+	[[Category: Ng LCT]]
-	~~[[Category: Petegem, F Van~~]]	+	[[Category: Putrenko I]]
-	[[Category: Putrenko, I]]	+	[[Category: Van Petegem F]]
-	[[Category: ~~Cycilc nucleotide binding domain]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 15:25, 8 July 2020

OCA — Wed, 08 Jul 2020 15:25:33 GMT

←Older revision		Revision as of 15:25, 8 July 2020
Line 1:		Line 1:

	==HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)==		==HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)==
-	<StructureSection load='5khj' size='340' side='right' caption='[[5khj]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='5khj' size='340' side='right'caption='[[5khj]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5khg\|5khg]], [[5khh\|5khh]], [[5khi\|5khi]], [[5khk\|5khk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5khg\|5khg]], [[5khh\|5khh]], [[5khi\|5khi]], [[5khk\|5khk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [http://pdbe.org/5khj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [http://www.ebi.ac.uk/pdbsum/5khj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hcn2, Bcng2, Hac1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [http://pdbe.org/5khj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [http://www.ebi.ac.uk/pdbsum/5khj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5khj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5khj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Accili, E A]]		[[Category: Accili, E A]]
	[[Category: Baronas, V]]		[[Category: Baronas, V]]

OCA at 15:16, 14 September 2016

OCA — Wed, 14 Sep 2016 15:16:35 GMT

←Older revision		Revision as of 15:16, 14 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5khj is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)==
		+	<StructureSection load='5khj' size='340' side='right' caption='[[5khj]], [[Resolution\|resolution]] 2.01Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5khg\|5khg]], [[5khh\|5khh]], [[5khi\|5khi]], [[5khk\|5khk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [http://pdbe.org/5khj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [http://www.ebi.ac.uk/pdbsum/5khj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic AMP is thought to facilitate the opening of the HCN2 channel by binding to a C-terminal domain and promoting or inhibiting interactions between subunits. Here, we correlated the ability of cyclic nucleotides to promote interactions of isolated HCN2 C-terminal domains in solution with their ability to facilitate channel opening. Cyclic IMP, a cyclic purine nucleotide, and cCMP, a cyclic pyrimidine nucleotide, bind to a C-terminal domain containing the cyclic nucleotide-binding domain but, in contrast to other cyclic nucleotides examined, fail to promote its oligomerization, and produce only modest facilitation of opening of the full-length channel. Comparisons between ligand bound structures identify a region between the sixth and seventh beta strands and the distal C helix as important for facilitation and tight binding. We propose that promotion of interactions between the C-terminal domains by a given ligand contribute to its ability to facilitate opening of the full-length channel.

-	~~Authors: Ng, L.~~C.T., ~~Putrenko~~, I., Baronas, V., Van Petegem, F., Accili, E.A.	+	Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.,Ng LC, Putrenko I, Baronas V, Van Petegem F, Accili EA Structure. 2016 Aug 23. pii: S0969-2126(16)30193-9. doi:, 10.1016/j.str.2016.06.024. PMID:27568927<ref>PMID:27568927</ref>

-	~~Description: HCN2 CNBD in complex with uridine-3'~~, ~~5'-cyclic monophosphate (cUMP)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Putrenko, I]]~~	+	<div class="pdbe-citations 5khj" style="background-color:#fffaf0;"></div>
-	[[Category: Accili, E.A]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Accili, E A]]
	[[Category: Baronas, V]]		[[Category: Baronas, V]]
-	[[Category: ~~Van~~ Petegem, F]]	+	[[Category: Ng, L C.T]]
-	[[Category: Ng, ~~L.C.T~~]]	+	[[Category: Petegem, F Van]]
		+	[[Category: Putrenko, I]]
		+	[[Category: Cycilc nucleotide binding domain]]
		+	[[Category: Ion transport]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Transport protein]]

OCA at 00:21, 13 July 2016

OCA — Wed, 13 Jul 2016 00:21:47 GMT

←Older revision		Revision as of 00:21, 13 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5khj is ON HOLD	+	The entry 5khj is ON HOLD until Paper Publication

	Authors: Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A.		Authors: Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A.

OCA: Protected "5khj" [edit=sysop:move=sysop]

OCA — Thu, 23 Jun 2016 21:37:40 GMT

Protected "5khj" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:37, 23 June 2016

OCA: New page: '''Unreleased structure''' The entry 5khj is ON HOLD Authors: Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A. Description: HCN2 CNBD in complex with uridine-3', 5'...

OCA — Thu, 23 Jun 2016 21:37:38 GMT

New page: '''Unreleased structure''' The entry 5khj is ON HOLD Authors: Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A. Description: HCN2 CNBD in complex with uridine-3', 5'...

New page

'''Unreleased structure'''

The entry 5khj is ON HOLD

Authors: Ng, L.C.T., Putrenko, I., Baronas, V., Van Petegem, F., Accili, E.A.

Description: HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP)
[[Category: Unreleased Structures]]
[[Category: Putrenko, I]]
[[Category: Accili, E.A]]
[[Category: Baronas, V]]
[[Category: Van Petegem, F]]
[[Category: Ng, L.C.T]]