5kj4 - Revision history

OCA at 10:01, 27 September 2023

OCA — Wed, 27 Sep 2023 10:01:50 GMT

←Older revision		Revision as of 10:01, 27 September 2023
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	<StructureSection load='5kj4' size='340' side='right'caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='5kj4' size='340' side='right'caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.35Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Pcdh15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj4 OCA], [~~http~~://pdbe.org/5kj4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kj4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kj4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj4 OCA], [https://pdbe.org/5kj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kj4 RCSB], [https://www.ebi.ac.uk/pdbsum/5kj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj4 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.	+	[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.	+	[https://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Araya-Secchi, R]]	+	[[Category: Araya-Secchi R]]
-	[[Category: Sotomayor, M]]	+	[[Category: Sotomayor M]]
-	~~[[Category: Adhesion]]~~	+
-	~~[[Category: Calcium-binding protein]]~~	+
-	~~[[Category: Hearing]]~~	+
-	~~[[Category: Mechanotransduction~~]]	+

OCA at 08:55, 18 December 2019

OCA — Wed, 18 Dec 2019 08:55:24 GMT

←Older revision		Revision as of 08:55, 18 December 2019
Line 1:		Line 1:

	==Crystal Structure of Mouse Protocadherin-15 EC9-10==		==Crystal Structure of Mouse Protocadherin-15 EC9-10==
-	<StructureSection load='5kj4' size='340' side='right' caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>	+	<StructureSection load='5kj4' size='340' side='right'caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Araya-Secchi, R]]		[[Category: Araya-Secchi, R]]

OCA at 05:45, 16 May 2018

OCA — Wed, 16 May 2018 05:45:44 GMT

←Older revision		Revision as of 05:45, 16 May 2018
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.		[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tip link filaments convey force and gate inner-ear hair-cell transduction channels to mediate perception of sound and head movements. Cadherin-23 and protocadherin-15 form tip links through a calcium-dependent interaction of their extracellular domains made of multiple extracellular cadherin (EC) repeats. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them. Here we present the X-ray crystal structures of human protocadherin-15 EC8-EC10 and mouse EC9-EC10, which show an EC8-9 canonical-like calcium-binding linker, and an EC9-10 calcium-free linker that alters the linear arrangement of EC repeats. Molecular dynamics simulations and small-angle X-ray scattering experiments support this non-linear conformation. Simulations also suggest that unbending of EC9-10 confers some elasticity to otherwise rigid tip links. The new structure provides a first view of protocadherin-15's non-canonical EC linkers and suggests how they may function in inner-ear mechanotransduction, with implications for other cadherins.
		+
		+	An elastic element in the protocadherin-15 tip link of the inner ear.,Araya-Secchi R, Neel BL, Sotomayor M Nat Commun. 2016 Nov 18;7:13458. doi: 10.1038/ncomms13458. PMID:27857071<ref>PMID:27857071</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5kj4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:21, 15 November 2017

OCA — Wed, 15 Nov 2017 18:21:31 GMT

←Older revision		Revision as of 18:21, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5kj4' size='340' side='right' caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>		<StructureSection load='5kj4' size='340' side='right' caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pcdh15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj4 OCA], [http://pdbe.org/5kj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5kj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj4 OCA], [http://pdbe.org/5kj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5kj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj4 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Araya-Secchi, R]]		[[Category: Araya-Secchi, R]]
	[[Category: Sotomayor, M]]		[[Category: Sotomayor, M]]

OCA at 10:56, 10 December 2016

OCA — Sat, 10 Dec 2016 10:56:03 GMT

←Older revision		Revision as of 10:56, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kj4 is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Mouse Protocadherin-15 EC9-10==
-		+	<StructureSection load='5kj4' size='340' side='right' caption='[[5kj4]], [[Resolution\|resolution]] 3.35Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kj4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJ4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kj4 OCA], [http://pdbe.org/5kj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5kj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kj4 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Araya-Secchi, R]]
		+	[[Category: Sotomayor, M]]
		+	[[Category: Adhesion]]
		+	[[Category: Calcium-binding protein]]
		+	[[Category: Hearing]]
		+	[[Category: Mechanotransduction]]

OCA at 09:20, 14 July 2016

OCA — Thu, 14 Jul 2016 09:20:28 GMT

←Older revision		Revision as of 09:20, 14 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kj4 is ON HOLD	+	The entry 5kj4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5kj4" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 00:25:00 GMT

Protected "5kj4" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:25, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kj4 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Jul 2016 00:24:59 GMT

New page: '''Unreleased structure''' The entry 5kj4 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5kj4 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]