5kkl - Revision history

OCA at 10:02, 27 September 2023

OCA — Wed, 27 Sep 2023 10:02:39 GMT

←Older revision		Revision as of 10:02, 27 September 2023
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	<StructureSection load='5kkl' size='340' side='right'caption='[[5kkl]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='5kkl' size='340' side='right'caption='[[5kkl]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kkl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kkl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KKL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SAM:S~~-~~ADENOSYLMETHIONINE'>SAM</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.94Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkl OCA], [~~http~~://pdbe.org/5kkl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kkl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kkl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkl OCA], [https://pdbe.org/5kkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kkl RCSB], [https://www.ebi.ac.uk/pdbsum/5kkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0S8H7_CHATD G0S8H7_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jiao, L]]	+	[[Category: Jiao L]]
-	[[Category: Liu, X]]	+	[[Category: Liu X]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Histone h3]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:27, 8 July 2020

OCA — Wed, 08 Jul 2020 15:27:31 GMT

←Older revision		Revision as of 15:27, 8 July 2020
Line 1:		Line 1:

	==Structure of ctPRC2 in complex with H3K27me3 and H3K27M==		==Structure of ctPRC2 in complex with H3K27me3 and H3K27M==
-	<StructureSection load='5kkl' size='340' side='right' caption='[[5kkl]], [[Resolution\|resolution]] 2.94Å' scene=''>	+	<StructureSection load='5kkl' size='340' side='right'caption='[[5kkl]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kkl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kkl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KKL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkl OCA], [http://pdbe.org/5kkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kkl RCSB], [http://www.ebi.ac.uk/pdbsum/5kkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkl OCA], [http://pdbe.org/5kkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kkl RCSB], [http://www.ebi.ac.uk/pdbsum/5kkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jiao, L]]		[[Category: Jiao, L]]
	[[Category: Liu, X]]		[[Category: Liu, X]]

OCA at 12:59, 19 April 2017

OCA — Wed, 19 Apr 2017 12:59:18 GMT

←Older revision		Revision as of 12:59, 19 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kkl is ~~ON HOLD~~	+	==Structure of ctPRC2 in complex with H3K27me3 and H3K27M==
		+	<StructureSection load='5kkl' size='340' side='right' caption='[[5kkl]], [[Resolution\|resolution]] 2.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kkl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KKL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kkl OCA], [http://pdbe.org/5kkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kkl RCSB], [http://www.ebi.ac.uk/pdbsum/5kkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kkl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.

-	~~Authors: Jiao~~, L., Liu, X.	+	Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".,Jiao L, Liu X Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaj2335. PMID:28008038<ref>PMID:28008038</ref>

-	~~Description: Structure~~ of ~~ctPRC2 in complex with H3K27me3 and H3K27M~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5kkl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Jiao, L]]		[[Category: Jiao, L]]
	[[Category: Liu, X]]		[[Category: Liu, X]]
		+	[[Category: Complex]]
		+	[[Category: Histone h3]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Transferase]]

OCA: Protected "5kkl" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 00:29:00 GMT

Protected "5kkl" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:29, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kkl is ON HOLD Authors: Jiao, L., Liu, X. Description: Structure of ctPRC2 in complex with H3K27me3 and H3K27M Category: Unreleased Structures...

OCA — Wed, 13 Jul 2016 00:28:58 GMT

New page: '''Unreleased structure''' The entry 5kkl is ON HOLD Authors: Jiao, L., Liu, X. Description: Structure of ctPRC2 in complex with H3K27me3 and H3K27M Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 5kkl is ON HOLD

Authors: Jiao, L., Liu, X.

Description: Structure of ctPRC2 in complex with H3K27me3 and H3K27M
[[Category: Unreleased Structures]]
[[Category: Jiao, L]]
[[Category: Liu, X]]