5kmx - Revision history

OCA at 10:03, 27 September 2023

OCA — Wed, 27 Sep 2023 10:03:56 GMT

←Older revision		Revision as of 10:03, 27 September 2023
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	<StructureSection load='5kmx' size='340' side='right'caption='[[5kmx]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='5kmx' size='340' side='right'caption='[[5kmx]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kmx]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Tryci Tryci~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KMX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kmx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_congolense_IL3000 Trypanosoma congolense IL3000]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KMX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~>, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.452Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~UNK~~:~~UNKNOWN~~'>~~UNK~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">TCIL3000_10_9440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 TRYCI])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmx OCA], [https://pdbe.org/5kmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kmx RCSB], [https://www.ebi.ac.uk/pdbsum/5kmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmx OCA], [~~http~~://pdbe.org/5kmx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kmx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kmx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmx ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0UXP9_TRYCI G0UXP9_TRYCI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tryci~~]]	+	[[Category: Trypanosoma congolense IL3000]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Parker~~, M L~~]]	+	[[Category: Parker ML]]
-	[[Category: Ramaswamy, R]]	+	[[Category: Ramaswamy R]]
-	~~[[Category: Bi-lobed architecture]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Putative sensor]]~~	+
-	~~[[Category: Surface protein~~]]	+

OCA at 08:09, 8 January 2020

OCA — Wed, 08 Jan 2020 08:09:37 GMT

←Older revision		Revision as of 08:09, 8 January 2020
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	==Structure of Trypanosoma congolense Insect Stage Antigen==		==Structure of Trypanosoma congolense Insect Stage Antigen==
-	<StructureSection load='5kmx' size='340' side='right' caption='[[5kmx]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='5kmx' size='340' side='right'caption='[[5kmx]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5kmx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryci Tryci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMX FirstGlance]. <br>		<table><tr><td colspan='2'>[[5kmx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryci Tryci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMX FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Tryci]]		[[Category: Tryci]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]

OCA at 06:09, 1 November 2017

OCA — Wed, 01 Nov 2017 06:09:07 GMT

←Older revision		Revision as of 06:09, 1 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5kmx is ~~ON HOLD until Paper~~ Publication	+	==Structure of Trypanosoma congolense Insect Stage Antigen==
		+	<StructureSection load='5kmx' size='340' side='right' caption='[[5kmx]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kmx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryci Tryci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCIL3000_10_9440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1068625 TRYCI])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmx OCA], [http://pdbe.org/5kmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kmx RCSB], [http://www.ebi.ac.uk/pdbsum/5kmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	African trypanosomiasis, caused by parasites of the genus Trypanosoma, is a complex of devastating vector-borne diseases of humans and livestock in sub-Saharan Africa. Central to the pathogenesis of African trypanosomes is their transmission by the arthropod vector, Glossina spp. (tsetse fly). Intriguingly, the efficiency of parasite transmission through the vector is reduced following depletion of Trypanosoma brucei Procyclic-Specific Surface Antigen-2 (TbPSSA-2). To investigate the underlying molecular mechanism of TbPSSA-2, we determined the crystal structures of its ectodomain and that of its homolog T. congolense Insect Stage Antigen (TcISA) to resolutions of 1.65 A and 2.45 A, respectively using single wavelength anomalous dispersion. Both proteins adopt a novel bilobed architecture with the individual lobes displaying rotational flexibility around the central tether that suggest a potential mechanism for coordinating a binding partner. In support of this hypothesis, electron density consistent with a bound peptide was observed in the inter-lob cleft of a TcISA monomer. These first reported structures of insect stage transmembrane proteins expressed by African trypanosomes provide potentially valuable insight into the interface between parasite and tsetse vector.

-	~~Authors~~:	+	Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA.,Ramaswamy R, Goomeshi Nobary S, Eyford BA, Pearson TW, Boulanger MJ Protein Sci. 2016 Dec;25(12):2297-2302. doi: 10.1002/pro.3053. Epub 2016 Oct 13. PMID:27671214<ref>PMID:27671214</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5kmx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Tryci]]
		+	[[Category: Boulanger, M J]]
		+	[[Category: Parker, M L]]
		+	[[Category: Ramaswamy, R]]
		+	[[Category: Bi-lobed architecture]]
		+	[[Category: Membrane protein]]
		+	[[Category: Putative sensor]]
		+	[[Category: Surface protein]]

OCA at 09:27, 14 July 2016

OCA — Thu, 14 Jul 2016 09:27:15 GMT

←Older revision		Revision as of 09:27, 14 July 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kmx is ON HOLD	+	The entry 5kmx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5kmx" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 00:34:54 GMT

Protected "5kmx" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:34, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kmx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Jul 2016 00:34:53 GMT

New page: '''Unreleased structure''' The entry 5kmx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5kmx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]