5kni - Revision history

OCA at 10:04, 27 September 2023

OCA — Wed, 27 Sep 2023 10:04:16 GMT

←Older revision		Revision as of 10:04, 27 September 2023
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	<StructureSection load='5kni' size='340' side='right'caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5kni' size='340' side='right'caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KNI FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP~~-~~ribosyltransferase NAD(+) ADP-ribosyltransferase]~~, ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~4.2.30 2.4.2.30] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kni OCA], [https://pdbe.org/5kni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kni RCSB], [https://www.ebi.ac.uk/pdbsum/5kni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kni ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kni OCA], [~~http~~://pdbe.org/5kni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kni ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>	+	[https://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Langelier~~, M F~~]]	+	[[Category: Langelier MF]]
-	[[Category: McCauley, M]]	+	[[Category: McCauley M]]
-	[[Category: Pascal~~, J M~~]]	+	[[Category: Pascal JM]]
-	[[Category: Riccio~~, A A]]~~	+	[[Category: Riccio AA]]
-	~~[[Category: Sterile alpha motif sam domain]]~~	+
-	~~[[Category: Tankyrase]]~~	+
-	~~[[Category: Tnk]]~~	+
-	~~[[Category: Tnks1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:19, 25 December 2019

OCA — Wed, 25 Dec 2019 12:19:34 GMT

←Older revision		Revision as of 12:19, 25 December 2019
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	==Crystal Structure of the wild-type SAM domain of human Tankyrase-1==		==Crystal Structure of the wild-type SAM domain of human Tankyrase-1==
-	<StructureSection load='5kni' size='340' side='right' caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5kni' size='340' side='right'caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNI FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5kni" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5kni" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Langelier, M F]]		[[Category: Langelier, M F]]
	[[Category: McCauley, M]]		[[Category: McCauley, M]]

OCA at 13:01, 6 November 2017

OCA — Mon, 06 Nov 2017 13:01:22 GMT

←Older revision		Revision as of 13:01, 6 November 2017
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	<StructureSection load='5kni' size='340' side='right' caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5kni' size='340' side='right' caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNI FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kni OCA], [http://pdbe.org/5kni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kni RCSB], [http://www.ebi.ac.uk/pdbsum/5kni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kni ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kni OCA], [http://pdbe.org/5kni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kni RCSB], [http://www.ebi.ac.uk/pdbsum/5kni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kni ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Langelier, M F]]		[[Category: Langelier, M F]]
	[[Category: McCauley, M]]		[[Category: McCauley, M]]

OCA at 13:58, 10 September 2016

OCA — Sat, 10 Sep 2016 13:58:18 GMT

←Older revision		Revision as of 13:58, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kni is ~~ON HOLD~~	+	==Crystal Structure of the wild-type SAM domain of human Tankyrase-1==
		+	<StructureSection load='5kni' size='340' side='right' caption='[[5kni]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kni]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNI FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kni OCA], [http://pdbe.org/5kni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kni RCSB], [http://www.ebi.ac.uk/pdbsum/5kni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kni ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tankyrase-1 (TNKS1/PARP-5a) is a poly(ADP-ribose) polymerase (PARP) enzyme that regulates multiple cellular processes creating a poly(ADP-ribose) posttranslational modification that can lead to target protein turnover. TNKS1 thereby controls protein levels of key components of signaling pathways, including Axin1, the limiting component of the destruction complex in canonical Wnt signaling that degrades beta-catenin to prevent its coactivator function in gene expression. There are limited molecular level insights into TNKS1 regulation in cell signaling pathways. TNKS1 has a sterile alpha motif (SAM) domain that is known to mediate polymerization, but the functional requirement for SAM polymerization has not been assessed. We have determined the crystal structure of wild-type human TNKS1 SAM domain and used structure-based mutagenesis to disrupt polymer formation and assess the consequences on TNKS1 regulation of beta-catenin-dependent transcription. Our data indicate the SAM polymer is critical for TNKS1 catalytic activity and allows TNKS1 to efficiently access cytoplasmic signaling complexes.

-	~~Authors: Pascal, J.M~~., ~~McCauley~~, M., Langelier, M.F., ~~Riccio, A~~.A	+	Tankyrase Sterile alpha Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.,Riccio AA, McCauley M, Langelier MF, Pascal JM Structure. 2016 Sep 6;24(9):1573-1581. doi: 10.1016/j.str.2016.06.022. Epub 2016 , Aug 4. PMID:27499439<ref>PMID:27499439</ref>

-	~~Description: Crystal Structure~~ of the ~~wild-type SAM domain~~ of ~~human Tankyrase~~-1	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Riccio~~, ~~A.A~~]]	+	<div class="pdbe-citations 5kni" style="background-color:#fffaf0;"></div>
-	[[Category: Pascal, J.M]]	+	== References ==
-	[[Category: ~~Langelier~~, ~~M.F~~]]	+	<references/>
-	[[Category: ~~Mccauley, M~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Langelier, M F]]
		+	[[Category: McCauley, M]]
		+	[[Category: Pascal, J M]]
		+	[[Category: Riccio, A A]]
		+	[[Category: Sterile alpha motif sam domain]]
		+	[[Category: Tankyrase]]
		+	[[Category: Tnk]]
		+	[[Category: Tnks1]]
		+	[[Category: Transferase]]

OCA: Protected "5kni" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 00:36:48 GMT

Protected "5kni" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:36, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kni is ON HOLD Authors: Pascal, J.M., McCauley, M., Langelier, M.F., Riccio, A.A Description: Crystal Structure of the wild-type SAM domain of hum...

OCA — Wed, 13 Jul 2016 00:36:46 GMT

New page: '''Unreleased structure''' The entry 5kni is ON HOLD Authors: Pascal, J.M., McCauley, M., Langelier, M.F., Riccio, A.A Description: Crystal Structure of the wild-type SAM domain of hum...

New page

'''Unreleased structure'''

The entry 5kni is ON HOLD

Authors: Pascal, J.M., McCauley, M., Langelier, M.F., Riccio, A.A

Description: Crystal Structure of the wild-type SAM domain of human Tankyrase-1
[[Category: Unreleased Structures]]
[[Category: Riccio, A.A]]
[[Category: Pascal, J.M]]
[[Category: Langelier, M.F]]
[[Category: Mccauley, M]]