5knp - Revision history

OCA at 10:04, 27 September 2023

OCA — Wed, 27 Sep 2023 10:04:32 GMT

←Older revision		Revision as of 10:04, 27 September 2023
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	==Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid==		==Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid==
-	<StructureSection load='5knp' size='340' side='right' caption='[[5knp]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='5knp' size='340' side='right'caption='[[5knp]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5knp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KNP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5knp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KNP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6W7:[(3~{S},4~{R})-4-(6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic+acid'>6W7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5knq\|5knq]], [[5kny\|5kny]], [[5knr\|5knr]], [[5kns\|5kns]], [[5knv\|5knv]], [[5knu\|5knu]], [[5knt\|5knt]], [[5knx\|5knx]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6W7:[(3~{S},4~{R})-4-(6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic+acid'>6W7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hpt, hprT, Rv3624c, MTCY15C10.28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5knp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5knp OCA], [https://pdbe.org/5knp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5knp RCSB], [https://www.ebi.ac.uk/pdbsum/5knp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5knp ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5knp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5knp OCA], [~~http~~://pdbe.org/5knp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5knp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5knp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5knp ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hypoxanthine phosphoribosyltransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Eng~~, W S~~]]	+	[[Category: Eng WS]]
-	[[Category: Guddat~~, L W~~]]	+	[[Category: Guddat LW]]
-	[[Category: Keough~~, D T~~]]	+	[[Category: Keough DT]]
-	[[Category: Rejman, D]]	+	[[Category: Rejman D]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Nucleoside phosphonate]]~~	+
-	~~[[Category: Phosphoribosyltransferase]]~~	+
-	~~[[Category: Transferase-inhibitor complex~~]]	+

OCA at 14:11, 15 November 2017

OCA — Wed, 15 Nov 2017 14:11:10 GMT

←Older revision		Revision as of 14:11, 15 November 2017
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-	'''Unreleased structure'''

-	~~The entry 5knp is ON HOLD until Paper Publication~~	+	==Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid==
-		+	<StructureSection load='5knp' size='340' side='right' caption='[[5knp]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5knp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KNP FirstGlance]. <br>
-	~~Description:~~ Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6W7:[(3~{S},4~{R})-4-(6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic+acid'>6W7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5knq\|5knq]], [[5kny\|5kny]], [[5knr\|5knr]], [[5kns\|5kns]], [[5knv\|5knv]], [[5knu\|5knu]], [[5knt\|5knt]], [[5knx\|5knx]]</td></tr>
-	[[Category: Eng, W.S]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hpt, hprT, Rv3624c, MTCY15C10.28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5knp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5knp OCA], [http://pdbe.org/5knp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5knp RCSB], [http://www.ebi.ac.uk/pdbsum/5knp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5knp ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hypoxanthine phosphoribosyltransferase]]
		+	[[Category: Myctu]]
		+	[[Category: Eng, W S]]
		+	[[Category: Guddat, L W]]
		+	[[Category: Keough, D T]]
	[[Category: Rejman, D]]		[[Category: Rejman, D]]
-	[[Category: ~~Keough, D.T~~]]	+	[[Category: Complex]]
-	[[Category: ~~Guddat, L.W~~]]	+	[[Category: Inhibitor]]
		+	[[Category: Nucleoside phosphonate]]
		+	[[Category: Phosphoribosyltransferase]]
		+	[[Category: Transferase-inhibitor complex]]

OCA at 13:10, 27 July 2016

OCA — Wed, 27 Jul 2016 13:10:08 GMT

←Older revision		Revision as of 13:10, 27 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5knp is ON HOLD	+	The entry 5knp is ON HOLD until Paper Publication

	Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W.		Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W.

OCA: Protected "5knp" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 00:37:17 GMT

Protected "5knp" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:37, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5knp is ON HOLD Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W. Description: Crystal structure of Mycobacterium tuberculosis hypoxanthin...

OCA — Wed, 13 Jul 2016 00:37:16 GMT

New page: '''Unreleased structure''' The entry 5knp is ON HOLD Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W. Description: Crystal structure of Mycobacterium tuberculosis hypoxanthin...

New page

'''Unreleased structure'''

The entry 5knp is ON HOLD

Authors: Eng, W.S., Rejman, D., Keough, D.T., Guddat, L.W.

Description: Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid
[[Category: Unreleased Structures]]
[[Category: Eng, W.S]]
[[Category: Rejman, D]]
[[Category: Keough, D.T]]
[[Category: Guddat, L.W]]