5kph - Revision history

OCA at 10:13, 14 June 2023

OCA — Wed, 14 Jun 2023 10:13:29 GMT

←Older revision		Revision as of 10:13, 14 June 2023
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	==Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485==		==Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485==
-	<StructureSection load='5kph' size='340' side='right'caption='[[5kph~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5kph' size='340' side='right'caption='[[5kph]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kph]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KPH FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpe\|5kpe]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [https://pdbe.org/5kph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [https://www.ebi.ac.uk/pdbsum/5kph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [~~http~~://pdbe.org/5kph PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kph PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Liu, G~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Montelione,~~ G T]]	+	[[Category: Liu G]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Montelione GT]]
-	[[Category: Tang, Y]]	+	[[Category: Tang Y]]
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Nesg]]~~	+
-	~~[[Category: Psi-biology~~]]	+

OCA at 06:30, 5 August 2020

OCA — Wed, 05 Aug 2020 06:30:31 GMT

←Older revision		Revision as of 06:30, 5 August 2020
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	==Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485==		==Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485==
-	<StructureSection load='5kph' size='340' side='right' caption='[[5kph]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5kph' size='340' side='right'caption='[[5kph]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kph]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KPH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kph]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KPH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpe\|5kpe]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpe\|5kpe]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [http://pdbe.org/5kph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [http://www.ebi.ac.uk/pdbsum/5kph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [http://pdbe.org/5kph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [http://www.ebi.ac.uk/pdbsum/5kph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, G]]		[[Category: Liu, G]]
	[[Category: Montelione, G T]]		[[Category: Montelione, G T]]

OCA at 10:55, 1 February 2017

OCA — Wed, 01 Feb 2017 10:55:06 GMT

←Older revision		Revision as of 10:55, 1 February 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [http://pdbe.org/5kph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [http://www.ebi.ac.uk/pdbsum/5kph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [http://pdbe.org/5kph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [http://www.ebi.ac.uk/pdbsum/5kph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Active sites and ligand-binding cavities in native proteins are often formed by curved beta sheets, and the ability to control beta-sheet curvature would allow design of binding proteins with cavities customized to specific ligands. Toward this end, we investigated the mechanisms controlling beta-sheet curvature by studying the geometry of beta sheets in naturally occurring protein structures and folding simulations. The principles emerging from this analysis were used to design, de novo, a series of proteins with curved beta sheets topped with alpha helices. Nuclear magnetic resonance and crystal structures of the designs closely match the computational models, showing that beta-sheet curvature can be controlled with atomic-level accuracy. Our approach enables the design of proteins with cavities and provides a route to custom design ligand-binding and catalytic sites.
		+
		+	Principles for designing proteins with cavities formed by curved beta sheets.,Marcos E, Basanta B, Chidyausiku TM, Tang Y, Oberdorfer G, Liu G, Swapna GV, Guan R, Silva DA, Dou J, Pereira JH, Xiao R, Sankaran B, Zwart PH, Montelione GT, Baker D Science. 2017 Jan 13;355(6321):201-206. doi: 10.1126/science.aah7389. PMID:28082595<ref>PMID:28082595</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5kph" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:10, 3 October 2016

OCA — Mon, 03 Oct 2016 17:10:50 GMT

←Older revision		Revision as of 17:10, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5kph is ON HOLD~~	+	==Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485==
-		+	<StructureSection load='5kph' size='340' side='right' caption='[[5kph]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors: Tang, Y., Liu, G., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kph]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KPH FirstGlance]. <br>
-	~~Description:~~ Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpe\|5kpe]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kph OCA], [http://pdbe.org/5kph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kph RCSB], [http://www.ebi.ac.uk/pdbsum/5kph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kph ProSAT]</span></td></tr>
-	[[Category: ~~Northeast~~ Structural ~~Genomics Consortium (Nesg)~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, G]]
		+	[[Category: Montelione, G T]]
		+	[[Category: Structural genomic]]
	[[Category: Tang, Y]]		[[Category: Tang, Y]]
-	[[Category: ~~Montelione, G.T~~]]	+	[[Category: De novo protein]]
-	[[Category: ~~Liu, G~~]]	+	[[Category: Nesg]]
		+	[[Category: Psi-biology]]

OCA: Protected "5kph" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 09:32:58 GMT

Protected "5kph" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:32, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kph is ON HOLD Authors: Tang, Y., Liu, G., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) Description: Solution NMR Structure o...

OCA — Thu, 14 Jul 2016 09:32:57 GMT

New page: '''Unreleased structure''' The entry 5kph is ON HOLD Authors: Tang, Y., Liu, G., Montelione, G.T., Northeast Structural Genomics Consortium (NESG) Description: Solution NMR Structure o...

New page

'''Unreleased structure'''

The entry 5kph is ON HOLD

Authors: Tang, Y., Liu, G., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)

Description: Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR485
[[Category: Unreleased Structures]]
[[Category: Northeast Structural Genomics Consortium (Nesg)]]
[[Category: Tang, Y]]
[[Category: Montelione, G.T]]
[[Category: Liu, G]]