5kpo - Revision history

OCA at 10:50, 27 September 2023

OCA — Wed, 27 Sep 2023 10:50:55 GMT

←Older revision		Revision as of 10:50, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='5kpo' size='340' side='right'caption='[[5kpo]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='5kpo' size='340' side='right'caption='[[5kpo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kpo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kpo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KPO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6WY:1~~-[[~~3-(4-ETHYL-3-OXIDANYLIDENE-PIPERAZIN-1-YL)CARBONYL-4-FLUORANYL-PHENYL~~]~~METHYL~~]~~QUINAZOLINE-~~2~~,4-DIONE'>6WY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5kpn\|5kpn]], [[5kpp\|5kpp]], [[5kpq\|5kpq]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WY:1-[[3-(4-ETHYL-3-OXIDANYLIDENE-PIPERAZIN-1-YL)CARBONYL-4-FLUORANYL-PHENYL]METHYL]QUINAZOLINE-2,4-DIONE'>6WY</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1, ADPRT, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kpo OCA], [https://pdbe.org/5kpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kpo RCSB], [https://www.ebi.ac.uk/pdbsum/5kpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kpo ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/NAD~~(~~+)_ADP~~-~~ribosyltransferase NAD(+~~) ~~ADP~~-~~ribosyltransferase~~]~~, with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2.4~~.2.30 2.4.2.30]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kpo OCA], [~~http~~://pdbe.org/5kpo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kpo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kpo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kpo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>	+	[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, R]]	+	[[Category: Cao R]]
-	[[Category: Huang, N]]	+	[[Category: Huang N]]
-	[[Category: Wang~~, Y L~~]]	+	[[Category: Wang YL]]
-	[[Category: Xu~~, B L~~]]	+	[[Category: Xu BL]]
-	[[Category: Yao~~, H P~~]]	+	[[Category: Yao HP]]
-	[[Category: Zhou, J]]	+	[[Category: Zhou J]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 06:31, 5 August 2020

OCA — Wed, 05 Aug 2020 06:31:03 GMT

←Older revision		Revision as of 06:31, 5 August 2020
Line 1:		Line 1:

	==Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor==		==Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor==
-	<StructureSection load='5kpo' size='340' side='right' caption='[[5kpo]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='5kpo' size='340' side='right'caption='[[5kpo]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kpo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kpo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KPO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6WY:1-[[3-(4-ETHYL-3-OXIDANYLIDENE-PIPERAZIN-1-YL)CARBONYL-4-FLUORANYL-PHENYL]METHYL]QUINAZOLINE-2,4-DIONE'>6WY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WY:1-[[3-(4-ETHYL-3-OXIDANYLIDENE-PIPERAZIN-1-YL)CARBONYL-4-FLUORANYL-PHENYL]METHYL]QUINAZOLINE-2,4-DIONE'>6WY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpn\|5kpn]], [[5kpp\|5kpp]], [[5kpq\|5kpq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpn\|5kpn]], [[5kpp\|5kpp]], [[5kpq\|5kpq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PARP1, ADPRT, PPOL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kpo OCA], [http://pdbe.org/5kpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kpo RCSB], [http://www.ebi.ac.uk/pdbsum/5kpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kpo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kpo OCA], [http://pdbe.org/5kpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kpo RCSB], [http://www.ebi.ac.uk/pdbsum/5kpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kpo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>		[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
		+
		+	==See Also==
		+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cao, R]]		[[Category: Cao, R]]
	[[Category: Huang, N]]		[[Category: Huang, N]]

OCA at 21:42, 22 December 2016

OCA — Thu, 22 Dec 2016 21:42:48 GMT

←Older revision		Revision as of 21:42, 22 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kpo is ~~ON HOLD~~	+	==Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor==
-		+	<StructureSection load='5kpo' size='340' side='right' caption='[[5kpo]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~Authors~~: ~~Cao~~, R., ~~Wang, Y~~.L., ~~Zhou~~, J., ~~Yao, H~~.P., ~~Huang, N~~., ~~Xu, B~~.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kpo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KPO FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~human PARP1 catalytic domain bound to~~ a ~~quinazoline~~-2,4(~~1H,3H~~)-~~dione inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6WY:1-[[3-(4-ETHYL-3-OXIDANYLIDENE-PIPERAZIN-1-YL)CARBONYL-4-FLUORANYL-PHENYL]METHYL]QUINAZOLINE-2,4-DIONE'>6WY</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kpn\|5kpn]], [[5kpp\|5kpp]], [[5kpq\|5kpq]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kpo OCA], [http://pdbe.org/5kpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kpo RCSB], [http://www.ebi.ac.uk/pdbsum/5kpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kpo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cao, R]]
	[[Category: Huang, N]]		[[Category: Huang, N]]
-	~~[[Category: Yao, H.P]]~~	+	[[Category: Wang, Y L]]
-	[[Category: Wang, Y.L]]	+	[[Category: Xu, B L]]
-	[[Category: ~~Cao~~, R]]	+	[[Category: Yao, H P]]
-	[[Category: Xu, ~~B.L~~]]	+
	[[Category: Zhou, J]]		[[Category: Zhou, J]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA: Protected "5kpo" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 09:33:30 GMT

Protected "5kpo" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kpo is ON HOLD Authors: Cao, R., Wang, Y.L., Zhou, J., Yao, H.P., Huang, N., Xu, B.L. Description: Structure of human PARP1 catalytic domain bound...

OCA — Thu, 14 Jul 2016 09:33:29 GMT

New page: '''Unreleased structure''' The entry 5kpo is ON HOLD Authors: Cao, R., Wang, Y.L., Zhou, J., Yao, H.P., Huang, N., Xu, B.L. Description: Structure of human PARP1 catalytic domain bound...

New page

'''Unreleased structure'''

The entry 5kpo is ON HOLD

Authors: Cao, R., Wang, Y.L., Zhou, J., Yao, H.P., Huang, N., Xu, B.L.

Description: Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
[[Category: Unreleased Structures]]
[[Category: Huang, N]]
[[Category: Yao, H.P]]
[[Category: Wang, Y.L]]
[[Category: Cao, R]]
[[Category: Xu, B.L]]
[[Category: Zhou, J]]