5kql - Revision history

OCA at 10:51, 27 September 2023

OCA — Wed, 27 Sep 2023 10:51:37 GMT

←Older revision		Revision as of 10:51, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='5kql' size='340' side='right'caption='[[5kql]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5kql' size='340' side='right'caption='[[5kql]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kql]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KQL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6VY:(1~{S})-2-OXIDANYLIDENE~~-1~~-PHENYL-2-PHENYLAZANYL-ETHANESULFONIC+ACID'>6VY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5kqg\|5kqg]], [[5kqm\|5kqm]], [[5kqp\|5kqp]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VY:(1~{S})-2-OXIDANYLIDENE-1-PHENYL-2-PHENYLAZANYL-ETHANESULFONIC+ACID'>6VY</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kql OCA], [https://pdbe.org/5kql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kql RCSB], [https://www.ebi.ac.uk/pdbsum/5kql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kql ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kql OCA], [~~http~~://pdbe.org/5kql PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kql RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kql PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kql ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.	+	[https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, J]]	+	[[Category: Wang J]]
-	[[Category: Yu, Z H]]	+	[[Category: Yu Z-H]]
-	[[Category: Zhang, Z Y]]	+	[[Category: Zhang Z-Y]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lmw-ptp~~]]	+

OCA at 06:31, 5 August 2020

OCA — Wed, 05 Aug 2020 06:31:49 GMT

←Older revision		Revision as of 06:31, 5 August 2020
Line 1:		Line 1:

	==Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid==		==Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid==
-	<StructureSection load='5kql' size='340' side='right' caption='[[5kql]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5kql' size='340' side='right'caption='[[5kql]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KQL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kql]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KQL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6VY:(1~{S})-2-OXIDANYLIDENE-1-PHENYL-2-PHENYLAZANYL-ETHANESULFONIC+ACID'>6VY</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VY:(1~{S})-2-OXIDANYLIDENE-1-PHENYL-2-PHENYLAZANYL-ETHANESULFONIC+ACID'>6VY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kqg\|5kqg]], [[5kqm\|5kqm]], [[5kqp\|5kqp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kqg\|5kqg]], [[5kqm\|5kqm]], [[5kqp\|5kqp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kql OCA], [http://pdbe.org/5kql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kql RCSB], [http://www.ebi.ac.uk/pdbsum/5kql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kql ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kql OCA], [http://pdbe.org/5kql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kql RCSB], [http://www.ebi.ac.uk/pdbsum/5kql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kql ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5kql" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5kql" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
	[[Category: Yu, Z H]]		[[Category: Yu, Z H]]

OCA at 17:44, 19 October 2016

OCA — Wed, 19 Oct 2016 17:44:20 GMT

←Older revision		Revision as of 17:44, 19 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kql is ~~ON HOLD until Paper~~ Publication	+	==Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid==
		+	<StructureSection load='5kql' size='340' side='right' caption='[[5kql]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KQL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6VY:(1~{S})-2-OXIDANYLIDENE-1-PHENYL-2-PHENYLAZANYL-ETHANESULFONIC+ACID'>6VY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kqg\|5kqg]], [[5kqm\|5kqm]], [[5kqp\|5kqp]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kql OCA], [http://pdbe.org/5kql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kql RCSB], [http://www.ebi.ac.uk/pdbsum/5kql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kql ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The low molecular weight protein tyrosine phosphatase (LMW-PTP) is a regulator of a number of signaling pathways and has been implicated as a potential target for oncology and diabetes/obesity. There is significant therapeutic interest in developing potent and selective inhibitors to control LMW-PTP activity. We report the discovery of a novel class of LMW-PTP inhibitors derived from sulfophenyl acetic amide (SPAA), some of which exhibit greater than 50-fold preference for LMW-PTP over a large panel of PTPs. X-ray crystallography reveals that binding of SPAA-based inhibitors induces a striking conformational change in the LMW-PTP active site, leading to the formation of a previously undisclosed hydrophobic pocket to accommodate the alpha-phenyl ring in the ligand. This induced-fit mechanism is likely a major contributor responsible for the exquisite inhibitor selectivity.

-	~~Authors: Wang~~, J., Zhang, ~~Z.-Y.~~, Yu, Z.-H.	+	Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.,He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY J Med Chem. 2016 Oct 3. PMID:27676368<ref>PMID:27676368</ref>

-	~~Description: Co-crystal structure~~ of ~~LMW~~-~~PTP in complex with 2~~-~~oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Yu, Z.-H]]~~	+	<div class="pdbe-citations 5kql" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Wang, J]]		[[Category: Wang, J]]
-	[[Category: Zhang, Z.-Y]]	+	[[Category: Yu, Z H]]
		+	[[Category: Zhang, Z Y]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Lmw-ptp]]

OCA at 12:43, 26 July 2016

OCA — Tue, 26 Jul 2016 12:43:34 GMT

←Older revision		Revision as of 12:43, 26 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kql is ON HOLD	+	The entry 5kql is ON HOLD until Paper Publication

	Authors: Wang, J., Zhang, Z.-Y., Yu, Z.-H.		Authors: Wang, J., Zhang, Z.-Y., Yu, Z.-H.

-	Description: Co-crystal structure of LMW-PTP in complex with ~~a SPAA~~-~~containing inhibitor compound 9~~	+	Description: Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yu, Z.-H]]		[[Category: Yu, Z.-H]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
	[[Category: Zhang, Z.-Y]]		[[Category: Zhang, Z.-Y]]

OCA: Protected "5kql" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 09:35:30 GMT

Protected "5kql" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:35, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kql is ON HOLD Authors: Wang, J., Zhang, Z.-Y., Yu, Z.-H. Description: Co-crystal structure of LMW-PTP in complex with a SPAA-containing inhibitor...

OCA — Thu, 14 Jul 2016 09:35:29 GMT

New page: '''Unreleased structure''' The entry 5kql is ON HOLD Authors: Wang, J., Zhang, Z.-Y., Yu, Z.-H. Description: Co-crystal structure of LMW-PTP in complex with a SPAA-containing inhibitor...

New page

'''Unreleased structure'''

The entry 5kql is ON HOLD

Authors: Wang, J., Zhang, Z.-Y., Yu, Z.-H.

Description: Co-crystal structure of LMW-PTP in complex with a SPAA-containing inhibitor compound 9
[[Category: Unreleased Structures]]
[[Category: Yu, Z.-H]]
[[Category: Wang, J]]
[[Category: Zhang, Z.-Y]]