5ksu - Revision history

OCA at 10:53, 27 September 2023

OCA — Wed, 27 Sep 2023 10:53:25 GMT

←Older revision		Revision as of 10:53, 27 September 2023
Line 1:		Line 1:

	==Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution==		==Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution==
-	<StructureSection load='5ksu' size='340' side='right' caption='[[5ksu]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='5ksu' size='340' side='right'caption='[[5ksu]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ksu]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ksu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KSU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ksv\|5ksv]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">HLA-DQA1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), HLA-DQB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ksu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksu OCA], [https://pdbe.org/5ksu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ksu RCSB], [https://www.ebi.ac.uk/pdbsum/5ksu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ksu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksu OCA], [~~http~~://pdbe.org/5ksu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ksu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ksu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN]] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.	+	[https://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5ksu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ksu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC II 3D structures\|MHC II 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Bergseng, E]]	+	[[Category: Large Structures]]
-	[[Category: Jayaraman, P]]	+	[[Category: Bergseng E]]
-	[[Category: Kim, C Y]]	+	[[Category: Jayaraman P]]
-	[[Category: Madhusudhan~~, M S~~]]	+	[[Category: Kim C-Y]]
-	[[Category: Nguyen, T B]]	+	[[Category: Madhusudhan MS]]
-	[[Category: Sollid~~, L M]]~~	+	[[Category: Nguyen T-B]]
-	~~[[Category: Celiac disease]]~~	+	[[Category: Sollid LM]]
-	~~[[Category: Clip]]~~	+
-	~~[[Category: Dq2 5]]~~	+
-	~~[[Category: Hla]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mhc~~]]	+

OCA at 06:23, 18 April 2018

OCA — Wed, 18 Apr 2018 06:23:58 GMT

←Older revision		Revision as of 06:23, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='5ksu' size='340' side='right' caption='[[5ksu]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='5ksu' size='340' side='right' caption='[[5ksu]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ksu]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ksu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KSU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ksv\|5ksv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ksv\|5ksv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-DQA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HLA-DQB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ksu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksu OCA], [http://pdbe.org/5ksu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ksu RCSB], [http://www.ebi.ac.uk/pdbsum/5ksu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ksu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksu OCA], [http://pdbe.org/5ksu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ksu RCSB], [http://www.ebi.ac.uk/pdbsum/5ksu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN]] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.		[[http://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN]] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human leukocyte antigen (HLA)-DQ2.5 (DQA105/DQB102) is a class-II major histocompatibility complex protein associated with both type 1 diabetes and celiac disease. One unusual feature of DQ2.5 is its high class-II-associated invariant chain peptide (CLIP) content. Moreover, HLA-DQ2.5 preferentially binds the non-canonical CLIP2 over the canonical CLIP1. To better understand the structural basis of HLA-DQ2.5's unusual CLIP association characteristics, better insight into the HLA-DQ2.5.CLIP complex structures is required. To this end, we determined the X-ray crystal structure of the HLA-DQ2.5. CLIP1 and HLA-DQ2.5.CLIP2 complexes at 2.73 and 2.20 A, respectively. We found that HLA-DQ2.5 has an unusually large P4 pocket and a positively charged peptide-binding groove that together promote preferential binding of CLIP2 over CLIP1. An alpha9-alpha22-alpha24-alpha31-beta86-beta90 hydrogen bond network located at the bottom of the peptide-binding groove, spanning from the P1 to P4 pockets, renders the residues in this region relatively immobile. This hydrogen bond network, along with a deletion mutation at alpha53, may lead to HLA-DM insensitivity in HLA-DQ2.5. A molecular dynamics simulation experiment reported here and recent biochemical studies by others support this hypothesis. The diminished HLA-DM sensitivity is the likely reason for the CLIP-rich phenotype of HLA-DQ2.5.
		+
		+	Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.,Nguyen TB, Jayaraman P, Bergseng E, Madhusudhan MS, Kim CY, Sollid LM J Biol Chem. 2017 Jun 2;292(22):9218-9228. doi: 10.1074/jbc.M117.785139. Epub, 2017 Mar 31. PMID:28364043<ref>PMID:28364043</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ksu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bergseng, E]]		[[Category: Bergseng, E]]
	[[Category: Jayaraman, P]]		[[Category: Jayaraman, P]]

OCA at 13:27, 5 April 2017

OCA — Wed, 05 Apr 2017 13:27:34 GMT

←Older revision		Revision as of 13:27, 5 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ksu is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution==
-		+	<StructureSection load='5ksu' size='340' side='right' caption='[[5ksu]], [[Resolution\|resolution]] 2.73Å' scene=''>
-	~~Authors~~: ~~Nguyen, T~~.-B., ~~Jayaraman~~, P., ~~Bergseng~~, E., ~~Madhusudhan, M~~.S., ~~Kim~~, C.-Y., ~~Sollid~~, L.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ksu]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KSU FirstGlance]. <br>
-	~~Description: Crystal structure~~ of HLA-~~DQ2~~.5-~~CLIP1 at 2~~.~~73 resolution~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ksv\|5ksv]]</td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ksu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksu OCA], [http://pdbe.org/5ksu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ksu RCSB], [http://www.ebi.ac.uk/pdbsum/5ksu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksu ProSAT]</span></td></tr>
-	~~[[Category: Sollid~~, L.~~M]]~~	+	</table>
-	[[Category: ~~Madhusudhan~~, ~~M.S~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN]] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bergseng, E]]
	[[Category: Jayaraman, P]]		[[Category: Jayaraman, P]]
-	[[Category: Nguyen, T.-B]]	+	[[Category: Kim, C Y]]
-	[[Category: ~~Bergseng~~, E]]	+	[[Category: Madhusudhan, M S]]
-	[[Category: ~~Kim, C.-Y~~]]	+	[[Category: Nguyen, T B]]
		+	[[Category: Sollid, L M]]
		+	[[Category: Celiac disease]]
		+	[[Category: Clip]]
		+	[[Category: Dq2 5]]
		+	[[Category: Hla]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc]]

OCA at 10:24, 9 March 2017

OCA — Thu, 09 Mar 2017 10:24:37 GMT

←Older revision		Revision as of 10:24, 9 March 2017
Line 7:		Line 7:
	Description: Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution		Description: Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Madhusudhan, M.S]]
	[[Category: Sollid, L.M]]		[[Category: Sollid, L.M]]
		+	[[Category: Madhusudhan, M.S]]
	[[Category: Jayaraman, P]]		[[Category: Jayaraman, P]]
	[[Category: Nguyen, T.-B]]		[[Category: Nguyen, T.-B]]
	[[Category: Bergseng, E]]		[[Category: Bergseng, E]]
	[[Category: Kim, C.-Y]]		[[Category: Kim, C.-Y]]

OCA at 13:19, 27 July 2016

OCA — Wed, 27 Jul 2016 13:19:38 GMT

←Older revision		Revision as of 13:19, 27 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ksu is ON HOLD	+	The entry 5ksu is ON HOLD until Paper Publication

	Authors: Nguyen, T.-B., Jayaraman, P., Bergseng, E., Madhusudhan, M.S., Kim, C.-Y., Sollid, L.M.		Authors: Nguyen, T.-B., Jayaraman, P., Bergseng, E., Madhusudhan, M.S., Kim, C.-Y., Sollid, L.M.

OCA: Protected "5ksu" [edit=sysop:move=sysop]

OCA — Tue, 26 Jul 2016 12:49:57 GMT

Protected "5ksu" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:49, 26 July 2016

OCA: New page: '''Unreleased structure''' The entry 5ksu is ON HOLD Authors: Nguyen, T.-B., Jayaraman, P., Bergseng, E., Madhusudhan, M.S., Kim, C.-Y., Sollid, L.M. Description: Crystal structure of ...

OCA — Tue, 26 Jul 2016 12:49:56 GMT

New page: '''Unreleased structure''' The entry 5ksu is ON HOLD Authors: Nguyen, T.-B., Jayaraman, P., Bergseng, E., Madhusudhan, M.S., Kim, C.-Y., Sollid, L.M. Description: Crystal structure of ...

New page

'''Unreleased structure'''

The entry 5ksu is ON HOLD

Authors: Nguyen, T.-B., Jayaraman, P., Bergseng, E., Madhusudhan, M.S., Kim, C.-Y., Sollid, L.M.

Description: Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution
[[Category: Unreleased Structures]]
[[Category: Madhusudhan, M.S]]
[[Category: Sollid, L.M]]
[[Category: Jayaraman, P]]
[[Category: Nguyen, T.-B]]
[[Category: Bergseng, E]]
[[Category: Kim, C.-Y]]