5kyn - Revision history

OCA at 11:02, 27 September 2023

OCA — Wed, 27 Sep 2023 11:02:04 GMT

←Older revision		Revision as of 11:02, 27 September 2023
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	==Structure of Sec23 and TANGO1 complex==		==Structure of Sec23 and TANGO1 complex==
-	<StructureSection load='5kyn' size='340' side='right' caption='[[5kyn]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='5kyn' size='340' side='right'caption='[[5kyn]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kyn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kyn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KYN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.552Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SEC23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyn OCA], [~~http~~://pdbe.org/5kyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyn OCA], [https://pdbe.org/5kyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kyn RCSB], [https://www.ebi.ac.uk/pdbsum/5kyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyn ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[~~http~~://omim.org/entry/607812 607812]]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>	+	[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[https://omim.org/entry/607812 607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.	+	[https://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Goldberg, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ma, W~~]]	+	[[Category: Goldberg J]]
-	[[Category: ~~Cargo adapter]]~~	+	[[Category: Ma W]]
-	~~[[Category: Collagen secretion]]~~	+
-	~~[[Category: Copii coat]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Vesicle~~]]	+

OCA at 23:12, 15 November 2017

OCA — Wed, 15 Nov 2017 23:12:23 GMT

←Older revision		Revision as of 23:12, 15 November 2017
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	<StructureSection load='5kyn' size='340' side='right' caption='[[5kyn]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='5kyn' size='340' side='right' caption='[[5kyn]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kyn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kyn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KYN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEC23A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyn OCA], [http://pdbe.org/5kyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kyn RCSB], [http://www.ebi.ac.uk/pdbsum/5kyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyn OCA], [http://pdbe.org/5kyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kyn RCSB], [http://www.ebi.ac.uk/pdbsum/5kyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyn ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Goldberg, J]]		[[Category: Goldberg, J]]
	[[Category: Ma, W]]		[[Category: Ma, W]]

OCA at 21:14, 10 September 2016

OCA — Sat, 10 Sep 2016 21:14:11 GMT

←Older revision		Revision as of 21:14, 10 September 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5kyn is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of Sec23 and TANGO1 complex==
		+	<StructureSection load='5kyn' size='340' side='right' caption='[[5kyn]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kyn]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KYN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kyn OCA], [http://pdbe.org/5kyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kyn RCSB], [http://www.ebi.ac.uk/pdbsum/5kyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kyn ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Defects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:[http://omim.org/entry/607812 607812]]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.<ref>PMID:16980979</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SC23A_HUMAN SC23A_HUMAN]] Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The supramolecular cargo procollagen is loaded into coat protein complex II (COPII)-coated carriers at endoplasmic reticulum (ER) exit sites by the receptor molecule TANGO1/cTAGE5. Electron microscopy studies have identified a tubular carrier of suitable dimensions that is molded by a distinctive helical array of the COPII inner coat protein Sec23/24*Sar1; the helical arrangement is absent from canonical COPII-coated small vesicles. In this study, we combined X-ray crystallographic and biochemical analysis to characterize the association of TANGO1/cTAGE5 with COPII proteins. The affinity for Sec23 is concentrated in the proline-rich domains (PRDs) of TANGO1 and cTAGE5, but Sec23 recognizes merely a PPP motif. The PRDs contain repeated PPP motifs separated by proline-rich linkers, so a single TANGO1/cTAGE5 receptor can bind multiple copies of coat protein in a close-packed array. We propose that TANGO1/cTAGE5 promotes the accretion of inner coat proteins to the helical lattice. Furthermore, we show that PPP motifs in the outer coat protein Sec31 also bind to Sec23, suggesting that stepwise COPII coat assembly will ultimately displace TANGO1/cTAGE5 and compartmentalize its operation to the base of the growing COPII tubule.

-	~~Authors: Ma~~, W., Goldberg, J.	+	TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.,Ma W, Goldberg J Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10061-6. doi:, 10.1073/pnas.1605916113. Epub 2016 Aug 22. PMID:27551091<ref>PMID:27551091</ref>

-	~~Description: Structure~~ of ~~Sec23 and TANGO1 complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Ma, W]]~~	+	<div class="pdbe-citations 5kyn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Goldberg, J]]		[[Category: Goldberg, J]]
		+	[[Category: Ma, W]]
		+	[[Category: Cargo adapter]]
		+	[[Category: Collagen secretion]]
		+	[[Category: Copii coat]]
		+	[[Category: Protein transport]]
		+	[[Category: Vesicle]]

OCA at 02:11, 4 August 2016

OCA — Thu, 04 Aug 2016 02:11:32 GMT

←Older revision		Revision as of 02:11, 4 August 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kyn is ON HOLD	+	The entry 5kyn is ON HOLD until Paper Publication

-	Authors: Ma, ~~Wenfu~~, Goldberg, ~~Jonathan~~	+	Authors: Ma, W., Goldberg, J.

-	Description: ~~structure~~ of Sec23 and TANGO1 complex	+	Description: Structure of Sec23 and TANGO1 complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ma, ~~Wenfu,~~ Goldberg, ~~Jonathan~~]]	+	[[Category: Ma, W]]
		+	[[Category: Goldberg, J]]

OCA: Protected "5kyn" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2016 13:32:49 GMT

Protected "5kyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:32, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kyn is ON HOLD Authors: Ma, Wenfu, Goldberg, Jonathan Description: structure of Sec23 and TANGO1 complex Category: Unreleased Structures [[Cat...

OCA — Wed, 27 Jul 2016 13:32:48 GMT

New page: '''Unreleased structure''' The entry 5kyn is ON HOLD Authors: Ma, Wenfu, Goldberg, Jonathan Description: structure of Sec23 and TANGO1 complex Category: Unreleased Structures [[Cat...

New page

'''Unreleased structure'''

The entry 5kyn is ON HOLD

Authors: Ma, Wenfu, Goldberg, Jonathan

Description: structure of Sec23 and TANGO1 complex
[[Category: Unreleased Structures]]
[[Category: Ma, Wenfu, Goldberg, Jonathan]]