5kzn - Revision history

OCA at 16:03, 4 October 2023

OCA — Wed, 04 Oct 2023 16:03:22 GMT

←Older revision		Revision as of 16:03, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5kzn' size='340' side='right'caption='[[5kzn]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5kzn' size='340' side='right'caption='[[5kzn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KZN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5kzq\|5kzq]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GRM2, GPRC1B, MGLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [https://pdbe.org/5kzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [https://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [~~http~~://pdbe.org/5kzn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>	+	[https://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antonysamy, S]]	+	[[Category: Antonysamy S]]
-	[[Category: Atwell, S]]	+	[[Category: Atwell S]]
-	[[Category: Barberis, M]]	+	[[Category: Barberis M]]
-	[[Category: Bedwell, D]]	+	[[Category: Bedwell D]]
-	[[Category: Blanco, M J]]	+	[[Category: Blanco M-J]]
-	[[Category: Bradley, C]]	+	[[Category: Bradley C]]
-	[[Category: Britton, T]]	+	[[Category: Britton T]]
-	[[Category: Bures, M]]	+	[[Category: Bures M]]
-	[[Category: Carpintero, M]]	+	[[Category: Carpintero M]]
-	[[Category: Catlow, J]]	+	[[Category: Catlow J]]
-	[[Category: Chappell~~, M D~~]]	+	[[Category: Chappell MD]]
-	[[Category: Condon, B]]	+	[[Category: Condon B]]
-	[[Category: Conners, K]]	+	[[Category: Conners K]]
-	~~[[Category: Diego, J E.de~~]]	+	[[Category: Dressman BA]]
-	[[Category: Dressman~~, B A~~]]	+	[[Category: Erickson JA]]
-	[[Category: Erickson~~, J A~~]]	+	[[Category: Fivush AM]]
-	[[Category: Fivush~~, A M~~]]	+	[[Category: Garcia-Cerrada S]]
-	[[Category: Garcia-Cerrada, S]]	+	[[Category: Groshong C]]
-	[[Category: Groshong, C]]	+	[[Category: Heinz BA]]
-	[[Category: Heinz~~, B A~~]]	+	[[Category: Jaramillo C]]
-	[[Category: Jaramillo, C]]	+	[[Category: Koss JW]]
-	[[Category: Koss~~, J W~~]]	+	[[Category: Li R]]
-	[[Category: Li, R]]	+	[[Category: Li X]]
-	[[Category: Li, X]]	+	[[Category: MacEwan I]]
-	[[Category: MacEwan, I]]	+	[[Category: Matt J]]
-	[[Category: Matt, J]]	+	[[Category: Mayhugh D]]
-	[[Category: Mayhugh, D]]	+	[[Category: Mitch CH]]
-	[[Category: Mitch~~, C H~~]]	+	[[Category: Monn JA]]
-	[[Category: Monn~~, J A~~]]	+	[[Category: Ornstein P]]
-	[[Category: Ornstein, P]]	+	[[Category: Overshiner C]]
-	[[Category: Overshiner, C]]	+	[[Category: Quimby SJ]]
-	[[Category: Quimby~~, S J~~]]	+	[[Category: Schkeryantz JM]]
-	[[Category: Schkeryantz~~, J M~~]]	+	[[Category: Seidel W]]
-	[[Category: Seidel, W]]	+	[[Category: Smith SC]]
-	[[Category: Smith~~, S C~~]]	+	[[Category: Soriano JF]]
-	[[Category: Soriano~~, J F~~]]	+	[[Category: Swanson S]]
-	[[Category: Swanson, S]]	+	[[Category: Tripp AE]]
-	[[Category: Tripp~~, A E~~]]	+	[[Category: Tromiczak EG]]
-	[[Category: Tromiczak~~, E G~~]]	+	[[Category: Vetman T]]
-	[[Category: Vetman, T]]	+	[[Category: Wafford KA]]
-	[[Category: Wafford~~, K A~~]]	+	[[Category: Wang J]]
-	[[Category: Wang, J]]	+	[[Category: Wang X-S]]
-	[[Category: Wang, X S]]	+	[[Category: Wasserman SR]]
-	[[Category: Wasserman~~, S R~~]]	+	[[Category: Witkin JM]]
-	[[Category: Witkin~~, J M~~]]	+	[[Category: Zhang A]]
-	[[Category: Zhang, A]]	+	[[Category: De Diego JE]]
-	[[Category: ~~Antagonist]]~~	+
-	~~[[Category: Antidepressent]]~~	+
-	~~[[Category: Mglur2]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:38, 5 August 2020

OCA — Wed, 05 Aug 2020 06:38:03 GMT

←Older revision		Revision as of 06:38, 5 August 2020
Line 1:		Line 1:

	==Metabotropic Glutamate Receptor==		==Metabotropic Glutamate Receptor==
-	<StructureSection load='5kzn' size='340' side='right' caption='[[5kzn]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5kzn' size='340' side='right'caption='[[5kzn]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KZN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kzq\|5kzq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kzq\|5kzq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [http://pdbe.org/5kzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [http://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GRM2, GPRC1B, MGLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [http://pdbe.org/5kzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [http://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5kzn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5kzn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metabotropic glutamate receptor 3D structures\|Metabotropic glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Antonysamy, S]]		[[Category: Antonysamy, S]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]

OCA at 09:39, 4 January 2017

OCA — Wed, 04 Jan 2017 09:39:32 GMT

←Older revision		Revision as of 09:39, 4 January 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>		[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonists. Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicy clo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371.HCl, 19f), a potent, selective, and maximally efficacious mGlu2/3 antagonist. Further characterization of compound 19f binding to the human metabotropic 2 glutamate (hmGlu2) site was established by cocrystallization of this molecule with the amino terminal domain (ATD) of the hmGlu2 receptor protein. The resulting cocrystal structure revealed the specific ligand-protein interactions, which likely explain the high affinity of 19f for this site and support its functional mGlu2 antagonist pharmacology. Further characterization of 19f in vivo demonstrated an antidepressant-like signature in the mouse forced-swim test (mFST) assay when brain levels of this compound exceeded the cellular mGlu2 IC50 value.
		+
		+	Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicy clo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371.HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.,Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C, Carpintero M, Diego JE, Barberis M, Garcia-Cerrada S, Soriano JF, Antonysamy S, Atwell S, MacEwan I, Condon B, Sougias C, Wang J, Zhang A, Conners K, Groshong C, Wasserman SR, Koss JW, Witkin JM, Li X, Overshiner C, Wafford KA, Seidel W, Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL J Med Chem. 2016 Dec 22;59(24):10974-10993. Epub 2016 Dec 6. PMID:28002967<ref>PMID:28002967</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5kzn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:25, 2 January 2017

OCA — Mon, 02 Jan 2017 16:25:34 GMT

←Older revision		Revision as of 16:25, 2 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kzn ~~is ON HOLD until Paper Publication~~	+	==Metabotropic Glutamate Receptor==
-		+	<StructureSection load='5kzn' size='340' side='right' caption='[[5kzn]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Chappell, M~~.D.~~, Li, R~~.~~, Smith, S~~.C.~~, Dressman, B~~.A.~~, Tromiczak, E~~.G., ~~Tripp, A.E., Blanco, M.~~-~~J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh,~~ D.~~, Erickson, J~~.A.~~, Bures, M~~., ~~Jaramillo, C~~.~~, Carpintero, M~~.~~, de Diego, J~~.~~E., Barberis, M., Garcia~~-~~Cerrada~~, S., ~~Soriano, J~~.F.~~, Antonysamy, S~~., ~~Atwell, S~~.~~, MacEwan, I~~.~~, Condon, B~~., ~~Bradley, C~~.~~, Wang, J~~.~~, Zhang, A~~.~~, Conners, K~~.~~, Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X~~.-~~S., Heinz~~, B.A.~~, Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kzn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KZN FirstGlance]. <br>
-	~~Description: Metabotropic Glutamate Receptor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kzq\|5kzq]]</td></tr>
-	[[Category: ~~Groshong~~, C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzn OCA], [http://pdbe.org/5kzn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzn RCSB], [http://www.ebi.ac.uk/pdbsum/5kzn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzn ProSAT]</span></td></tr>
-	[[Category: ~~Jaramillo~~, C]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Antonysamy, S]]
		+	[[Category: Atwell, S]]
	[[Category: Barberis, M]]		[[Category: Barberis, M]]
		+	[[Category: Bedwell, D]]
		+	[[Category: Blanco, M J]]
		+	[[Category: Bradley, C]]
	[[Category: Britton, T]]		[[Category: Britton, T]]
-	[[Category: Mayhugh, D]]
-	[[Category: Wasserman, S.R]]
-	[[Category: Zhang, A]]
-	[[Category: Bradley, C]]
-	[[Category: Blanco, M.-J]]
-	[[Category: Bedwell, D]]
-	[[Category: Quimby, S.J]]
	[[Category: Bures, M]]		[[Category: Bures, M]]
-	[[Category: Li, R]]
-	[[Category: Witkin, J.M]]
-	[[Category: Wang, J]]
-	[[Category: Ornstein, P]]
-	[[Category: Macewan, I]]
-	[[Category: Smith, S.C]]
-	[[Category: Seidel, W]]
-	[[Category: Chappell, M.D]]
	[[Category: Carpintero, M]]		[[Category: Carpintero, M]]
-	[[Category: Erickson, J.A]]
	[[Category: Catlow, J]]		[[Category: Catlow, J]]
-	[[Category: ~~Wafford~~, ~~K.A]]~~	+	[[Category: Chappell, M D]]
-	~~[[Category: Vetman, T]]~~	+
-	~~[[Category: Monn, J.A]]~~	+
-	~~[[Category: Soriano, J.F]]~~	+
-	~~[[Category: Tromiczak, E.G]]~~	+
-	~~[[Category: Matt, J]]~~	+
-	~~[[Category: Mitch, C.H]]~~	+
-	~~[[Category: Swanson, S]]~~	+
-	~~[[Category: Atwell, S~~]]	+
	[[Category: Condon, B]]		[[Category: Condon, B]]
	[[Category: Conners, K]]		[[Category: Conners, K]]
-	[[Category: ~~Wang~~, X.-S]]	+	[[Category: Diego, J E.de]]
		+	[[Category: Dressman, B A]]
		+	[[Category: Erickson, J A]]
		+	[[Category: Fivush, A M]]
		+	[[Category: Garcia-Cerrada, S]]
		+	[[Category: Groshong, C]]
		+	[[Category: Heinz, B A]]
		+	[[Category: Jaramillo, C]]
		+	[[Category: Koss, J W]]
		+	[[Category: Li, R]]
		+	[[Category: Li, X]]
		+	[[Category: MacEwan, I]]
		+	[[Category: Matt, J]]
		+	[[Category: Mayhugh, D]]
		+	[[Category: Mitch, C H]]
		+	[[Category: Monn, J A]]
		+	[[Category: Ornstein, P]]
	[[Category: Overshiner, C]]		[[Category: Overshiner, C]]
-	[[Category: Li, X]]	+	[[Category: Quimby, S J]]
-	[[Category: ~~Koss~~, J.W]]	+	[[Category: Schkeryantz, J M]]
-	[[Category: ~~Dressman~~, ~~B.A~~]]	+	[[Category: Seidel, W]]
-	[[Category: ~~De Diego~~, J.E]]	+	[[Category: Smith, S C]]
-	[[Category: Tripp, A.E]]	+	[[Category: Soriano, J F]]
-	[[Category: ~~Garcia-Cerrada~~, S]]	+	[[Category: Swanson, S]]
-	[[Category: ~~Schkeryantz~~, ~~J.M~~]]	+	[[Category: Tripp, A E]]
-	[[Category: ~~Heinz~~, B.A]]	+	[[Category: Tromiczak, E G]]
-	[[Category: ~~Fivush~~, ~~A.M~~]]	+	[[Category: Vetman, T]]
-	[[Category: ~~Antonysamy~~, S]]	+	[[Category: Wafford, K A]]
		+	[[Category: Wang, J]]
		+	[[Category: Wang, X S]]
		+	[[Category: Wasserman, S R]]
		+	[[Category: Witkin, J M]]
		+	[[Category: Zhang, A]]
		+	[[Category: Antagonist]]
		+	[[Category: Antidepressent]]
		+	[[Category: Mglur2]]
		+	[[Category: Signaling protein]]

OCA at 15:22, 26 October 2016

OCA — Wed, 26 Oct 2016 15:22:32 GMT

←Older revision		Revision as of 15:22, 26 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kzn is ON HOLD	+	The entry 5kzn is ON HOLD until Paper Publication

	Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.		Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.

OCA at 14:28, 9 September 2016

OCA — Fri, 09 Sep 2016 14:28:15 GMT

←Older revision		Revision as of 14:28, 9 September 2016
Line 3:		Line 3:
	The entry 5kzn is ON HOLD		The entry 5kzn is ON HOLD

-	Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J. E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.	+	Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.

	Description: Metabotropic Glutamate Receptor		Description: Metabotropic Glutamate Receptor
Line 24:		Line 24:
	[[Category: Ornstein, P]]		[[Category: Ornstein, P]]
	[[Category: Macewan, I]]		[[Category: Macewan, I]]
-	[[Category: De Diego, J. E]]
	[[Category: Smith, S.C]]		[[Category: Smith, S.C]]
	[[Category: Seidel, W]]		[[Category: Seidel, W]]
Line 47:		Line 46:
	[[Category: Koss, J.W]]		[[Category: Koss, J.W]]
	[[Category: Dressman, B.A]]		[[Category: Dressman, B.A]]
		+	[[Category: De Diego, J.E]]
	[[Category: Tripp, A.E]]		[[Category: Tripp, A.E]]
	[[Category: Garcia-Cerrada, S]]		[[Category: Garcia-Cerrada, S]]

OCA: Protected "5kzn" [edit=sysop:move=sysop]

OCA — Thu, 04 Aug 2016 02:15:14 GMT

Protected "5kzn" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:15, 4 August 2016

OCA: New page: '''Unreleased structure''' The entry 5kzn is ON HOLD Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J.,...

OCA — Thu, 04 Aug 2016 02:15:10 GMT

New page: '''Unreleased structure''' The entry 5kzn is ON HOLD Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J.,...

New page

'''Unreleased structure'''

The entry 5kzn is ON HOLD

Authors: Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J. E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.

Description: Metabotropic Glutamate Receptor
[[Category: Unreleased Structures]]
[[Category: Groshong, C]]
[[Category: Jaramillo, C]]
[[Category: Barberis, M]]
[[Category: Britton, T]]
[[Category: Mayhugh, D]]
[[Category: Wasserman, S.R]]
[[Category: Zhang, A]]
[[Category: Bradley, C]]
[[Category: Blanco, M.-J]]
[[Category: Bedwell, D]]
[[Category: Quimby, S.J]]
[[Category: Bures, M]]
[[Category: Li, R]]
[[Category: Witkin, J.M]]
[[Category: Wang, J]]
[[Category: Ornstein, P]]
[[Category: Macewan, I]]
[[Category: De Diego, J. E]]
[[Category: Smith, S.C]]
[[Category: Seidel, W]]
[[Category: Chappell, M.D]]
[[Category: Carpintero, M]]
[[Category: Erickson, J.A]]
[[Category: Catlow, J]]
[[Category: Wafford, K.A]]
[[Category: Vetman, T]]
[[Category: Monn, J.A]]
[[Category: Soriano, J.F]]
[[Category: Tromiczak, E.G]]
[[Category: Matt, J]]
[[Category: Mitch, C.H]]
[[Category: Swanson, S]]
[[Category: Atwell, S]]
[[Category: Condon, B]]
[[Category: Conners, K]]
[[Category: Wang, X.-S]]
[[Category: Overshiner, C]]
[[Category: Li, X]]
[[Category: Koss, J.W]]
[[Category: Dressman, B.A]]
[[Category: Tripp, A.E]]
[[Category: Garcia-Cerrada, S]]
[[Category: Schkeryantz, J.M]]
[[Category: Heinz, B.A]]
[[Category: Fivush, A.M]]
[[Category: Antonysamy, S]]