5l2q - Revision history

OCA at 12:47, 4 October 2023

OCA — Wed, 04 Oct 2023 12:47:41 GMT

←Older revision		Revision as of 12:47, 4 October 2023
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	<StructureSection load='5l2q' size='340' side='right'caption='[[5l2q]], [[Resolution\|resolution]] 2.53Å' scene=''>		<StructureSection load='5l2q' size='340' side='right'caption='[[5l2q]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l2q]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5L2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L2Q FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>STK40, SGK495, SHIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non~~-~~specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase]~~, ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.11.1 2.7.11.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2q OCA], [https://pdbe.org/5l2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l2q RCSB], [https://www.ebi.ac.uk/pdbsum/5l2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2q OCA], [~~http~~://pdbe.org/5l2q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5l2q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5l2q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STK40_HUMAN STK40_HUMAN]] May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.<ref>PMID:13679039</ref>	+	[https://www.uniprot.org/uniprot/STK40_HUMAN STK40_HUMAN] May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.<ref>PMID:13679039</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Blacklow SC]]
-	[[Category: Blacklow~~, S C~~]]	+	[[Category: Durzynska I]]
-	[[Category: Durzynska, I]]	+	[[Category: Uljon S]]
-	[[Category: Uljon, S]]	+
-	~~[[Category: Pseudokinase sink-homologous serine/threonine-protein kinase sugen kinase 495]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:17, 4 December 2019

OCA — Wed, 04 Dec 2019 09:17:39 GMT

←Older revision		Revision as of 09:17, 4 December 2019
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	==Serine/threonine-protein kinase 40 (STK40) kinase homology domain==		==Serine/threonine-protein kinase 40 (STK40) kinase homology domain==
-	<StructureSection load='5l2q' size='340' side='right' caption='[[5l2q]], [[Resolution\|resolution]] 2.53Å' scene=''>	+	<StructureSection load='5l2q' size='340' side='right'caption='[[5l2q]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l2q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L2Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l2q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L2Q FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STK40, SGK495, SHIK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2q OCA], [http://pdbe.org/5l2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l2q RCSB], [http://www.ebi.ac.uk/pdbsum/5l2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2q OCA], [http://pdbe.org/5l2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l2q RCSB], [http://www.ebi.ac.uk/pdbsum/5l2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2q ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5l2q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5l2q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Blacklow, S C]]		[[Category: Blacklow, S C]]

OCA at 18:00, 1 February 2017

OCA — Wed, 01 Feb 2017 18:00:11 GMT

←Older revision		Revision as of 18:00, 1 February 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5l2q is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Serine/threonine-protein kinase 40 (STK40) kinase homology domain==
		+	<StructureSection load='5l2q' size='340' side='right' caption='[[5l2q]], [[Resolution\|resolution]] 2.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5l2q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L2Q FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2q OCA], [http://pdbe.org/5l2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l2q RCSB], [http://www.ebi.ac.uk/pdbsum/5l2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2q ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STK40_HUMAN STK40_HUMAN]] May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.<ref>PMID:13679039</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serine/threonine kinase 40 (STK40) was originally identified as a distant homolog of Tribbles-family proteins. Despite accumulating data attesting to the importance of STK40 in a variety of different physiologic processes, little is known about its biological activity or mechanism of action. Here, we show that STK40 interacts with Constitutive Photomorphogenic Protein 1 (COP1), relying primarily on a C-terminal sequence analogous to the motif found in Tribbles proteins. In order to further elucidate structure-function relationships in STK40, we determined the crystal structure of the STK40 kinase homology domain at 2.5 A resolution. The structure, together with ATP-binding assay results, show that STK40 is a pseudokinase, in which substitutions of conserved residues within the kinase domain prevent ATP binding. Although the structure of the kinase homology domain diverges from the analogous region of Trib1, the results reported here suggest functional parallels between STK40 and Tribbles-family proteins as COP1 adaptors.

-	~~Authors~~:	+	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.,Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC Structure. 2016 Dec 24. pii: S0969-2126(16)30398-7. doi:, 10.1016/j.str.2016.12.008. PMID:28089446<ref>PMID:28089446</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5l2q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Blacklow, S C]]
		+	[[Category: Durzynska, I]]
		+	[[Category: Uljon, S]]
		+	[[Category: Pseudokinase sink-homologous serine/threonine-protein kinase sugen kinase 495]]
		+	[[Category: Transferase]]

OCA at 17:56, 22 December 2016

OCA — Thu, 22 Dec 2016 17:56:33 GMT

←Older revision		Revision as of 17:56, 22 December 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5l2q is ON HOLD	+	The entry 5l2q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 15:38, 9 December 2016

OCA — Fri, 09 Dec 2016 15:38:58 GMT

←Older revision		Revision as of 15:38, 9 December 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5l2q is ON HOLD ~~until Paper Publication~~	+	The entry 5l2q is ON HOLD

	Authors:		Authors:

OCA at 14:33, 9 September 2016

OCA — Fri, 09 Sep 2016 14:33:17 GMT

←Older revision		Revision as of 14:33, 9 September 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5l2q is ON HOLD	+	The entry 5l2q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5l2q" [edit=sysop:move=sysop]

OCA — Wed, 10 Aug 2016 14:02:38 GMT

Protected "5l2q" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:02, 10 August 2016

OCA: New page: '''Unreleased structure''' The entry 5l2q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Aug 2016 14:02:36 GMT

New page: '''Unreleased structure''' The entry 5l2q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5l2q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]