5l4r - Revision history

OCA at 16:06, 4 October 2023

OCA — Wed, 04 Oct 2023 16:06:58 GMT

←Older revision		Revision as of 16:06, 4 October 2023
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	<StructureSection load='5l4r' size='340' side='right'caption='[[5l4r]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5l4r' size='340' side='right'caption='[[5l4r]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l4r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Katemfe Katemfe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5L4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thaumatococcus_daniellii Thaumatococcus daniellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L4R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73M:BIS(AZANYL)-CHLORANYL-OXIDANYL-PLATINUM'>73M</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4r OCA], [~~http~~://pdbe.org/5l4r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5l4r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5l4r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4r ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73M:BIS(AZANYL)-CHLORANYL-OXIDANYL-PLATINUM'>73M</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4r OCA], [https://pdbe.org/5l4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l4r RCSB], [https://www.ebi.ac.uk/pdbsum/5l4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/THM1_THADA THM1_THADA]] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.	+	[https://www.uniprot.org/uniprot/THM1_THADA THM1_THADA] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Katemfe]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ferraro, G~~]]	+	[[Category: Thaumatococcus daniellii]]
-	[[Category: ~~Krauss, I Russo~~]]	+	[[Category: Ferraro G]]
-	[[Category: Merlino, A]]	+	[[Category: Merlino A]]
-	[[Category: ~~Cisplatin]]~~	+	[[Category: Russo Krauss I]]
-	~~[[Category: Drug]]~~	+
-	~~[[Category: Model protein]]~~	+
-	~~[[Category: Plant protein~~]]	+

OCA at 06:43, 5 August 2020

OCA — Wed, 05 Aug 2020 06:43:51 GMT

←Older revision		Revision as of 06:43, 5 August 2020
Line 1:		Line 1:

	==X-ray structure of the adduct between thaumatin and cisplatin==		==X-ray structure of the adduct between thaumatin and cisplatin==
-	<StructureSection load='5l4r' size='340' side='right' caption='[[5l4r]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5l4r' size='340' side='right'caption='[[5l4r]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l4r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5L4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l4r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Katemfe Katemfe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L4R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73M:BIS(AZANYL)-CHLORANYL-OXIDANYL-PLATINUM'>73M</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=73M:BIS(AZANYL)-CHLORANYL-OXIDANYL-PLATINUM'>73M</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4r OCA], [http://pdbe.org/5l4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4r RCSB], [http://www.ebi.ac.uk/pdbsum/5l4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4r OCA], [http://pdbe.org/5l4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4r RCSB], [http://www.ebi.ac.uk/pdbsum/5l4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Katemfe]]
		+	[[Category: Large Structures]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
	[[Category: Krauss, I Russo]]		[[Category: Krauss, I Russo]]

OCA at 19:30, 9 December 2016

OCA — Fri, 09 Dec 2016 19:30:18 GMT

←Older revision		Revision as of 19:30, 9 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5l4r is ~~ON HOLD~~	+	==X-ray structure of the adduct between thaumatin and cisplatin==
		+	<StructureSection load='5l4r' size='340' side='right' caption='[[5l4r]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5l4r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L4R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=73M:BIS(AZANYL)-CHLORANYL-OXIDANYL-PLATINUM'>73M</scene>, <scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4r OCA], [http://pdbe.org/5l4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4r RCSB], [http://www.ebi.ac.uk/pdbsum/5l4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4r ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THM1_THADA THM1_THADA]] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Literature studies carried out by mass spectrometry and X-ray crystallography have demonstrated that cisplatin is able to bind proteins mainly close to Met, His, and free Cys side chains. To identify possible alternative modes of cisplatin binding to proteins at the molecular level, here we have solved the high-resolution X-ray structure of the adduct formed in the reaction between the drug and the model protein thaumatin, which does not contain any His and free Cys residues and possesses just one buried Met. Our data reveal unexpected cisplatin binding sites on the protein surface that could have general significance: cisplatin fragments -[Pt(NH3)2Cl](+), -[Pt(NH3)Cl2], and -[Pt(NH3)2(OH2)](2+) bind to a protein N-terminus and close to Lys and Glu side chains.

-	~~Authors~~: Russo Krauss, I., Ferraro, G., Merlino, A.	+	Cisplatin-Protein Interactions: Unexpected Drug Binding to N-Terminal Amine and Lysine Side Chains.,Russo Krauss I, Ferraro G, Merlino A Inorg Chem. 2016 Aug 15;55(16):7814-6. doi: 10.1021/acs.inorgchem.6b01234. Epub, 2016 Aug 2. PMID:27482735<ref>PMID:27482735</ref>

-	~~Description: X-ray structure~~ of the ~~adduct between thaumatin and cisplatin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5l4r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
		+	[[Category: Krauss, I Russo]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
-	[[Category: ~~Russo Krauss, I~~]]	+	[[Category: Cisplatin]]
		+	[[Category: Drug]]
		+	[[Category: Model protein]]
		+	[[Category: Plant protein]]

OCA at 14:35, 9 September 2016

OCA — Fri, 09 Sep 2016 14:35:43 GMT

←Older revision		Revision as of 14:35, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5l4r is ON HOLD ~~until sometime in the future~~	+	The entry 5l4r is ON HOLD

	Authors: Russo Krauss, I., Ferraro, G., Merlino, A.		Authors: Russo Krauss, I., Ferraro, G., Merlino, A.

OCA: Protected "5l4r" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 14:30:31 GMT

Protected "5l4r" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:30, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5l4r is ON HOLD until sometime in the future Authors: Russo Krauss, I., Ferraro, G., Merlino, A. Description: X-ray structure of the adduct between...

OCA — Wed, 01 Jun 2016 14:30:29 GMT

New page: '''Unreleased structure''' The entry 5l4r is ON HOLD until sometime in the future Authors: Russo Krauss, I., Ferraro, G., Merlino, A. Description: X-ray structure of the adduct between...

New page

'''Unreleased structure'''

The entry 5l4r is ON HOLD until sometime in the future

Authors: Russo Krauss, I., Ferraro, G., Merlino, A.

Description: X-ray structure of the adduct between thaumatin and cisplatin
[[Category: Unreleased Structures]]
[[Category: Ferraro, G]]
[[Category: Merlino, A]]
[[Category: Russo Krauss, I]]