5l56 - Revision history

OCA at 16:07, 4 October 2023

OCA — Wed, 04 Oct 2023 16:07:25 GMT

←Older revision		Revision as of 16:07, 4 October 2023
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	==Plexin A1 full extracellular region, domains 1 to 10, to 4 angstrom==		==Plexin A1 full extracellular region, domains 1 to 10, to 4 angstrom==
-	<StructureSection load='5l56' size='340' side='right' caption='[[5l56]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<StructureSection load='5l56' size='340' side='right'caption='[[5l56]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l56]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L56 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5L56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L56 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plxna1, Kiaa4053 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l56 OCA], [~~http~~://pdbe.org/5l56 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5l56 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5l56 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5l56 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l56 OCA], [https://pdbe.org/5l56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l56 RCSB], [https://www.ebi.ac.uk/pdbsum/5l56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l56 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref>	+	[https://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Plexin\|Plexin]]	+	*[[Plexin 3D structures\|Plexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: Coles~~, C H~~]]	+	[[Category: Mus musculus]]
-	[[Category: Gilbert~~, R J.C~~]]	+	[[Category: Coles CH]]
-	[[Category: Janssen~~, B J.C~~]]	+	[[Category: Gilbert RJC]]
-	[[Category: Jones~~, E Y~~]]	+	[[Category: Janssen BJC]]
-	[[Category: Kaufmann, R]]	+	[[Category: Jones EY]]
-	[[Category: Kong, Y]]	+	[[Category: Kaufmann R]]
-	[[Category: Malinauskas, T]]	+	[[Category: Kong Y]]
-	[[Category: Ni, T]]	+	[[Category: Malinauskas T]]
-	[[Category: Padilla-Parra, S]]	+	[[Category: Ni T]]
-	[[Category: Pasterkamp~~, R J~~]]	+	[[Category: Padilla-Parra S]]
-	[[Category: Vangoor~~, V R]]~~	+	[[Category: Pasterkamp RJ]]
-	~~[[Category: Axon guidance]]~~	+	[[Category: Vangoor VR]]
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Signaling]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 20:05, 19 September 2018

OCA — Wed, 19 Sep 2018 20:05:16 GMT

←Older revision		Revision as of 20:05, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='5l56' size='340' side='right' caption='[[5l56]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='5l56' size='340' side='right' caption='[[5l56]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l56]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L56 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l56]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L56 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Plxna1, Kiaa4053 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l56 OCA], [http://pdbe.org/5l56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l56 RCSB], [http://www.ebi.ac.uk/pdbsum/5l56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l56 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l56 OCA], [http://pdbe.org/5l56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l56 RCSB], [http://www.ebi.ac.uk/pdbsum/5l56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l56 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5l56" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5l56" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Plexin\|Plexin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Coles, C H]]		[[Category: Coles, C H]]
	[[Category: Gilbert, R J.C]]		[[Category: Gilbert, R J.C]]

OCA at 06:32, 26 July 2016

OCA — Tue, 26 Jul 2016 06:32:52 GMT

←Older revision		Revision as of 06:32, 26 July 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref>		[[http://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear. Here we present crystal structures of PlxnA (PlxnA1, PlxnA2, and PlxnA4) full ectodomains. Domains 1-9 form a ring-like conformation from which the C-terminal domain 10 points away. All our PlxnA ectodomain structures show autoinhibitory, intermolecular "head-to-stalk" (domain 1 to domain 4-5) interactions, which are confirmed by biophysical assays, live cell fluorescence microscopy, and cell-based and neuronal growth cone collapse assays. This work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding. More generally, our data identify a novel molecular mechanism for preventing premature activation of axon guidance receptors.
		+
		+	Structural Basis for Plexin Activation and Regulation.,Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY Neuron. 2016 Jul 5. pii: S0896-6273(16)30295-1. doi:, 10.1016/j.neuron.2016.06.018. PMID:27397516<ref>PMID:27397516</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5l56" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:05, 13 July 2016

OCA — Wed, 13 Jul 2016 18:05:21 GMT

←Older revision		Revision as of 18:05, 13 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5l56 is ~~ON HOLD~~	+	==Plexin A1 full extracellular region, domains 1 to 10, to 4 angstrom==
-		+	<StructureSection load='5l56' size='340' side='right' caption='[[5l56]], [[Resolution\|resolution]] 4.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5l56]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L56 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l56 OCA], [http://pdbe.org/5l56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l56 RCSB], [http://www.ebi.ac.uk/pdbsum/5l56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l56 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Coles, C H]]
		+	[[Category: Gilbert, R J.C]]
		+	[[Category: Janssen, B J.C]]
		+	[[Category: Jones, E Y]]
		+	[[Category: Kaufmann, R]]
		+	[[Category: Kong, Y]]
		+	[[Category: Malinauskas, T]]
		+	[[Category: Ni, T]]
		+	[[Category: Padilla-Parra, S]]
		+	[[Category: Pasterkamp, R J]]
		+	[[Category: Vangoor, V R]]
		+	[[Category: Axon guidance]]
		+	[[Category: Receptor]]
		+	[[Category: Signaling]]
		+	[[Category: Signaling protein]]

OCA: Protected "5l56" [edit=sysop:move=sysop]

OCA — Mon, 20 Jun 2016 13:54:03 GMT

Protected "5l56" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:54, 20 June 2016

OCA: New page: '''Unreleased structure''' The entry 5l56 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Mon, 20 Jun 2016 13:54:02 GMT

New page: '''Unreleased structure''' The entry 5l56 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5l56 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]