5l9a - Revision history

OCA at 16:12, 4 October 2023

OCA — Wed, 04 Oct 2023 16:12:02 GMT

←Older revision		Revision as of 16:12, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5l9a' size='340' side='right'caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5l9a' size='340' side='right'caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5L9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L9A FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [~~http~~://pdbe.org/5l9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [https://pdbe.org/5l9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [https://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7YW97_9TRYP Q7YW97_9TRYP]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: L-threonine 3-dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adjogatse, E]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: Cooper~~, J B~~]]	+	[[Category: Adjogatse E]]
-	[[Category: Erskine~~, P T~~]]	+	[[Category: Cooper JB]]
-	[[Category: Kelly, J]]	+	[[Category: Erskine PT]]
-	[[Category: Wood~~, S P]]~~	+	[[Category: Kelly J]]
-	~~[[Category: Apo-enzyme]]~~	+	[[Category: Wood SP]]
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 07:02, 5 August 2020

OCA — Wed, 05 Aug 2020 07:02:58 GMT

←Older revision		Revision as of 07:02, 5 August 2020
Line 1:		Line 1:

	==L-threonine dehydrogenase from trypanosoma brucei.==		==L-threonine dehydrogenase from trypanosoma brucei.==
-	<StructureSection load='5l9a' size='340' side='right' caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5l9a' size='340' side='right'caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5L9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: L-threonine 3-dehydrogenase]]		[[Category: L-threonine 3-dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Adjogatse, E]]		[[Category: Adjogatse, E]]
	[[Category: Cooper, J B]]		[[Category: Cooper, J B]]

OCA at 08:22, 10 October 2018

OCA — Wed, 10 Oct 2018 08:22:10 GMT

←Older revision		Revision as of 08:22, 10 October 2018
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two of the world's most neglected tropical diseases, human African trypanosomiasis (HAT) and Chagas disease, are caused by protozoan parasites of the genus Trypanosoma. These organisms possess specialized metabolic pathways, frequently distinct from those in humans, which have potential to be exploited as novel drug targets. This study elucidates the structure and function of L-threonine-3-dehydrogenase (TDH) from T. brucei, the causative pathogen of HAT. TDH is a key enzyme in the metabolism of L-threonine, and an inhibitor of TDH has been shown to have trypanocidal activity in the procyclic form of T. brucei. TDH is a nonfunctional pseudogene in humans, suggesting that it may be possible to rationally design safe and specific therapies for trypanosomiasis by targeting this parasite enzyme. As an initial step, the TDH gene from T. brucei was expressed and the three-dimensional structure of the enzyme was solved by X-ray crystallography. In multiple crystallographic structures, T. brucei TDH is revealed to be a dimeric short-chain dehydrogenase that displays a considerable degree of conformational variation in its ligand-binding regions. Geometric simulations of the structure have provided insight into the dynamic behaviour of this enzyme. Furthermore, structures of TDH bound to its natural substrates and known inhibitors have been determined, giving an indication of the mechanism of catalysis of the enzyme. Collectively, these results provide vital details for future drug design to target TDH or related enzymes.
		+
		+	Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.,Adjogatse E, Erskine P, Wells SA, Kelly JM, Wilden JD, Chan AWE, Selwood D, Coker A, Wood S, Cooper JB Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):861-876. doi:, 10.1107/S2059798318009208. Epub 2018 Sep 3. PMID:30198897<ref>PMID:30198897</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5l9a" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:05, 19 September 2018

OCA — Wed, 19 Sep 2018 20:05:20 GMT

←Older revision		Revision as of 20:05, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='5l9a' size='340' side='right' caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5l9a' size='340' side='right' caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L9A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>

OCA at 02:30, 13 July 2016

OCA — Wed, 13 Jul 2016 02:30:35 GMT

←Older revision		Revision as of 02:30, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l9a ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 23:31, 23 June 2016

OCA — Thu, 23 Jun 2016 23:31:43 GMT

←Older revision		Revision as of 23:31, 23 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5l9a ~~is ON HOLD~~	+	==L-threonine dehydrogenase from trypanosoma brucei.==
-		+	<StructureSection load='5l9a' size='340' side='right' caption='[[5l9a]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors~~: ~~Erskine, P~~.T.~~, Cooper, J~~.B.~~, Adjogatse, E~~.~~, Kelly, J~~.~~, Wood, S~~. P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5l9a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L9A FirstGlance]. <br>
-	~~Description~~: L-threonine dehydrogenase ~~from trypanosoma brucei~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonine_3-dehydrogenase L-threonine 3-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.103 1.1.1.103] </span></td></tr>
-	[[Category: ~~Erskine~~, ~~P.T~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l9a OCA], [http://pdbe.org/5l9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l9a RCSB], [http://www.ebi.ac.uk/pdbsum/5l9a PDBsum]</span></td></tr>
-	[[Category: Cooper, J.B]]	+	</table>
-	[[Category: ~~Wood~~, S. P]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: L-threonine 3-dehydrogenase]]
		+	[[Category: Adjogatse, E]]
		+	[[Category: Cooper, J B]]
		+	[[Category: Erskine, P T]]
	[[Category: Kelly, J]]		[[Category: Kelly, J]]
-	[[Category: ~~Adjogatse~~, E]]	+	[[Category: Wood, S P]]
		+	[[Category: Apo-enzyme]]
		+	[[Category: Dehydrogenase]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA: Protected "5l9a" [edit=sysop:move=sysop]

OCA — Mon, 20 Jun 2016 14:04:58 GMT

Protected "5l9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:04, 20 June 2016

OCA: New page: '''Unreleased structure''' The entry 5l9a is ON HOLD Authors: Erskine, P.T., Cooper, J.B., Adjogatse, E., Kelly, J., Wood, S. P. Description: L-threonine dehydrogenase from trypanosoma...

OCA — Mon, 20 Jun 2016 14:04:57 GMT

New page: '''Unreleased structure''' The entry 5l9a is ON HOLD Authors: Erskine, P.T., Cooper, J.B., Adjogatse, E., Kelly, J., Wood, S. P. Description: L-threonine dehydrogenase from trypanosoma...

New page

'''Unreleased structure'''

The entry 5l9a is ON HOLD

Authors: Erskine, P.T., Cooper, J.B., Adjogatse, E., Kelly, J., Wood, S. P.

Description: L-threonine dehydrogenase from trypanosoma brucei.
[[Category: Unreleased Structures]]
[[Category: Erskine, P.T]]
[[Category: Cooper, J.B]]
[[Category: Wood, S. P]]
[[Category: Kelly, J]]
[[Category: Adjogatse, E]]