5lf2 - Revision history

OCA at 08:58, 11 October 2023

OCA — Wed, 11 Oct 2023 08:58:12 GMT

←Older revision		Revision as of 08:58, 11 October 2023
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	<StructureSection load='5lf2' size='340' side='right'caption='[[5lf2]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5lf2' size='340' side='right'caption='[[5lf2]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lf2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LF2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lf2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LF2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Lamb2 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf2 OCA], [~~http~~://pdbe.org/5lf2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lf2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lf2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf2 OCA], [https://pdbe.org/5lf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lf2 RCSB], [https://www.ebi.ac.uk/pdbsum/5lf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LAMB2_RAT LAMB2_RAT]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	+	[https://www.uniprot.org/uniprot/LAMB2_RAT LAMB2_RAT] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hohenester, E~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Pulido, D~~]]	+	[[Category: Hohenester E]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Pulido D]]
-	~~[[Category: Extracellular matrix~~]]	+

OCA at 07:08, 5 August 2020

OCA — Wed, 05 Aug 2020 07:08:35 GMT

←Older revision		Revision as of 07:08, 5 August 2020
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	==Crystal structure of laminin beta2 LE5-LF-LE6==		==Crystal structure of laminin beta2 LE5-LF-LE6==
-	<StructureSection load='5lf2' size='340' side='right' caption='[[5lf2]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='5lf2' size='340' side='right'caption='[[5lf2]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lf2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LF2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lf2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LF2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf2 OCA], [http://pdbe.org/5lf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf2 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Lamb2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf2 OCA], [http://pdbe.org/5lf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5lf2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lf2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laminin\|Laminin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]
	[[Category: Pulido, D]]		[[Category: Pulido, D]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Extracellular matrix]]		[[Category: Extracellular matrix]]

OCA at 15:49, 27 July 2016

OCA — Wed, 27 Jul 2016 15:49:36 GMT

←Older revision		Revision as of 15:49, 27 July 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5lf2 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of laminin beta2 LE5-LF-LE6==
		+	<StructureSection load='5lf2' size='340' side='right' caption='[[5lf2]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lf2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LF2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf2 OCA], [http://pdbe.org/5lf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LAMB2_RAT LAMB2_RAT]] Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Laminins are a major constituent of all basement membranes. The polymerisation of laminins at the cell surface is mediated by the three short arms of the cross-shaped laminin heterotrimer. The short arms contain repeats of laminin-type epidermal growth factor-like (LE) domains, interspersed with globular domains of unknown function. A single LF domain is inserted between LE5 and LE6 of the laminin beta1 and beta2 chains. We report the crystal structure at 1.85A resolution of the laminin beta2 LE5-LF-LE6 region. The LF domain consists of a beta-sandwich related to bacterial family 35 carbohydrate binding modules, and more distantly to the L4 domains present in the short arms of laminin alpha and gamma chains. An alpha-helical region mediates the extensive interaction of the LF domain with LE5. The relative arrangement of LE5 and LE6 is very similar to that of consecutive LE domains in uninterrupted LE tandems. Fitting atomic models to a low-resolution structure of the first eight domains of the laminin beta1 chain determined by small-angle X-ray scattering suggests a deviation from the regular LE array at the LE4-LE5 junction. These results advance our understanding of laminin structure.

-	~~Authors: Pulido~~, D., ~~Hohenester~~, E.	+	Crystallographic analysis of the laminin beta2 short arm reveals how the LF domain is inserted into a regular array of LE domains.,Pulido D, Briggs DC, Hua J, Hohenester E Matrix Biol. 2016 Jul 16. pii: S0945-053X(16)30079-8. doi:, 10.1016/j.matbio.2016.06.006. PMID:27425256<ref>PMID:27425256</ref>

-	~~Description: Crystal structure~~ of ~~laminin beta2 LE5~~-LF-~~LE6~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5lf2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hohenester, E]]		[[Category: Hohenester, E]]
	[[Category: Pulido, D]]		[[Category: Pulido, D]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Extracellular matrix]]

OCA at 10:01, 14 July 2016

OCA — Thu, 14 Jul 2016 10:01:52 GMT

←Older revision		Revision as of 10:01, 14 July 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lf2 is ON HOLD	+	The entry 5lf2 is ON HOLD until Paper Publication

	Authors: Pulido, D., Hohenester, E.		Authors: Pulido, D., Hohenester, E.

OCA: Protected "5lf2" [edit=sysop:move=sysop]

OCA — Wed, 13 Jul 2016 01:05:33 GMT

Protected "5lf2" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:05, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lf2 is ON HOLD Authors: Pulido, D., Hohenester, E. Description: Crystal structure of laminin beta2 LE5-LF-LE6 Category: Unreleased Structures ...

OCA — Wed, 13 Jul 2016 01:05:31 GMT

New page: '''Unreleased structure''' The entry 5lf2 is ON HOLD Authors: Pulido, D., Hohenester, E. Description: Crystal structure of laminin beta2 LE5-LF-LE6 Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 5lf2 is ON HOLD

Authors: Pulido, D., Hohenester, E.

Description: Crystal structure of laminin beta2 LE5-LF-LE6
[[Category: Unreleased Structures]]
[[Category: Hohenester, E]]
[[Category: Pulido, D]]