5lg8 - Revision history

OCA at 08:59, 11 October 2023

OCA — Wed, 11 Oct 2023 08:59:08 GMT

←Older revision		Revision as of 08:59, 11 October 2023
Line 1:		Line 1:

	==Human L-type ferritin iron loaded for 60 minutes==		==Human L-type ferritin iron loaded for 60 minutes==
-	<StructureSection load='5lg8' size='340' side='right' caption='[[5lg8]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='5lg8' size='340' side='right'caption='[[5lg8]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lg8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lg2\|5lg2]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg8 OCA], [https://pdbe.org/5lg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lg8 RCSB], [https://www.ebi.ac.uk/pdbsum/5lg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg8 OCA], [~~http~~://pdbe.org/5lg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[~~http~~://omim.org/entry/600886 600886]]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[~~http~~://omim.org/entry/606159 606159]]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>	+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[https://omim.org/entry/600886 600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[https://omim.org/entry/606159 606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>	+	[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5lg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lg8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Mangani, S~~]]	+	[[Category: Large Structures]]
-	[[Category: Pisa, F Di]]	+	[[Category: Di Pisa F]]
-	[[Category: ~~Pozzi, C~~]]	+	[[Category: Mangani S]]
-	[[Category: ~~Ferritin]]~~	+	[[Category: Pozzi C]]
-	~~[[Category: Iron]]~~	+
-	~~[[Category: L-type]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Mineralization~~]]	+

OCA at 06:55, 31 January 2018

OCA — Wed, 31 Jan 2018 06:55:57 GMT

←Older revision		Revision as of 06:55, 31 January 2018
Line 3:		Line 3:
	<StructureSection load='5lg8' size='340' side='right' caption='[[5lg8]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5lg8' size='340' side='right' caption='[[5lg8]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lg8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LG8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lg2\|5lg2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lg2\|5lg2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg8 OCA], [http://pdbe.org/5lg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg8 OCA], [http://pdbe.org/5lg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg8 ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Mangani, S]]		[[Category: Mangani, S]]
	[[Category: Pisa, F Di]]		[[Category: Pisa, F Di]]

OCA at 08:13, 9 March 2017

OCA — Thu, 09 Mar 2017 08:13:11 GMT

←Older revision		Revision as of 08:13, 9 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lg8 is ~~ON HOLD~~	+	==Human L-type ferritin iron loaded for 60 minutes==
		+	<StructureSection load='5lg8' size='340' side='right' caption='[[5lg8]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lg8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LG8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lg2\|5lg2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lg8 OCA], [http://pdbe.org/5lg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lg8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lg8 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[http://omim.org/entry/600886 600886]]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref> Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[http://omim.org/entry/606159 606159]]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	X-ray structures of homopolymeric L-ferritin obtained by freezing protein crystals at increasing exposure times to a ferrous solution showed the progressive formation of a triiron cluster on the inner cage surface of each subunit. After 60 min exposure, a fully assembled (mu3-oxo)Tris[(mu2-peroxo)(mu2-glutamato-kappaO:kappaO')](glutamato-kappaO)(diaqu o)triiron(III) anionic cluster appears in human L-ferritin. Glu60, Glu61, and Glu64 provide the anchoring of the cluster to the protein cage. Glu57 shuttles incoming iron ions toward the cluster. We observed a similar metallocluster in horse spleen L-ferritin, indicating that it represents a common feature of mammalian L-ferritins. The structures suggest a mechanism for iron mineral formation at the protein interface. The functional significance of the observed patch of carboxylate side chains and resulting metallocluster for biomineralization emerges from the lower iron oxidation rate measured in the E60AE61AE64A variant of human L-ferritin, leading to the proposal that the observed metallocluster corresponds to the suggested, but yet unobserved, nucleation site of L-ferritin.

-	~~Authors:~~ Pozzi, C., Di Pisa, F., Mangani, S.	+	Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (mu3-oxo)Tris[(mu2-peroxo)] triiron(III) cluster.,Pozzi C, Ciambellotti S, Bernacchioni C, Di Pisa F, Mangani S, Turano P Proc Natl Acad Sci U S A. 2017 Feb 15. pii: 201614302. doi:, 10.1073/pnas.1614302114. PMID:28202724<ref>PMID:28202724</ref>

-	~~Description: Human L-type ferritin iron loaded for 60 minutes~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Pozzi, C]]~~	+	<div class="pdbe-citations 5lg8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mangani, S]]		[[Category: Mangani, S]]
-	[[Category: Di Pisa, F]]	+	[[Category: Pisa, F Di]]
		+	[[Category: Pozzi, C]]
		+	[[Category: Ferritin]]
		+	[[Category: Iron]]
		+	[[Category: L-type]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Mineralization]]

OCA at 15:50, 9 December 2016

OCA — Fri, 09 Dec 2016 15:50:51 GMT

←Older revision		Revision as of 15:50, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lg8 is ON HOLD ~~until sometime in the future~~	+	The entry 5lg8 is ON HOLD

	Authors: Pozzi, C., Di Pisa, F., Mangani, S.		Authors: Pozzi, C., Di Pisa, F., Mangani, S.

OCA at 13:28, 26 July 2016

OCA — Tue, 26 Jul 2016 13:28:17 GMT

←Older revision		Revision as of 13:28, 26 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lg8 is ON HOLD	+	The entry 5lg8 is ON HOLD until sometime in the future

	Authors: Pozzi, C., Di Pisa, F., Mangani, S.		Authors: Pozzi, C., Di Pisa, F., Mangani, S.

OCA: Protected "5lg8" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 10:06:08 GMT

Protected "5lg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lg8 is ON HOLD Authors: Pozzi, C., Di Pisa, F., Mangani, S. Description: Human L-type ferritin iron loaded for 60 minutes [[Category: Unreleased S...

OCA — Thu, 14 Jul 2016 10:06:07 GMT

New page: '''Unreleased structure''' The entry 5lg8 is ON HOLD Authors: Pozzi, C., Di Pisa, F., Mangani, S. Description: Human L-type ferritin iron loaded for 60 minutes [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 5lg8 is ON HOLD

Authors: Pozzi, C., Di Pisa, F., Mangani, S.

Description: Human L-type ferritin iron loaded for 60 minutes
[[Category: Unreleased Structures]]
[[Category: Pozzi, C]]
[[Category: Mangani, S]]
[[Category: Di Pisa, F]]