5lgk - Revision history

OCA at 18:24, 18 October 2023

OCA — Wed, 18 Oct 2023 18:24:22 GMT

←Older revision		Revision as of 18:24, 18 October 2023
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	<StructureSection load='5lgk' size='340' side='right'caption='[[5lgk]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5lgk' size='340' side='right'caption='[[5lgk]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lgk]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lgk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LGK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~IGHE ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), FCER2, CD23A, CLEC4J, FCE2, IGEBF ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgk OCA], [~~http~~://pdbe.org/5lgk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lgk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lgk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgk OCA], [https://pdbe.org/5lgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lgk RCSB], [https://www.ebi.ac.uk/pdbsum/5lgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~FCER2_HUMAN FCER2_HUMAN~~]~~] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).~~	+	[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dhaliwal, B]]	+	[[Category: Dhaliwal B]]
-	[[Category: Pang~~, M O.Y~~]]	+	[[Category: Pang MOY]]
-	[[Category: Sutton~~, B J]]~~	+	[[Category: Sutton BJ]]
-	~~[[Category: Antibody receptor]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold lectin~~]]	+

OCA at 10:36, 12 August 2020

OCA — Wed, 12 Aug 2020 10:36:25 GMT

←Older revision		Revision as of 10:36, 12 August 2020
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	==Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23==		==Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23==
-	<StructureSection load='5lgk' size='340' side='right' caption='[[5lgk]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5lgk' size='340' side='right'caption='[[5lgk]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lgk]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lgk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LGK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgk OCA], [http://pdbe.org/5lgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lgk RCSB], [http://www.ebi.ac.uk/pdbsum/5lgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgk ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FCER2, CD23A, CLEC4J, FCE2, IGEBF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgk OCA], [http://pdbe.org/5lgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lgk RCSB], [http://www.ebi.ac.uk/pdbsum/5lgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dhaliwal, B]]		[[Category: Dhaliwal, B]]
	[[Category: Pang, M O.Y]]		[[Category: Pang, M O.Y]]

OCA at 05:02, 12 April 2017

OCA — Wed, 12 Apr 2017 05:02:50 GMT

←Older revision		Revision as of 05:02, 12 April 2017
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).		[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The antibody IgE plays a central role in allergic disease mechanisms. Its effector functions are controlled through interactions between the Fc region and two principal cell surface receptors FcepsilonRI and CD23. The interaction with FcepsilonRI is primarily responsible for allergic sensitization and the inflammatory response, while IgE binding to CD23 is involved in the regulation of IgE synthesis and allergen transcytosis. Here we present the crystal structure of a CD23/IgE-Fc complex and conduct isothermal titration calorimetric binding studies. Two lectin-like "head" domains of CD23 bind to IgE-Fc with affinities that differ by more than an order of magnitude, but the crystal structure reveals only one head bound to one of the two identical heavy-chains in the asymmetrically bent IgE-Fc. These results highlight the subtle interplay between receptor binding sites in IgE-Fc and their affinities, the understanding of which may be exploited for therapeutic intervention in allergic disease.
		+
		+	IgE binds asymmetrically to its B cell receptor CD23.,Dhaliwal B, Pang MO, Keeble AH, James LK, Gould HJ, McDonnell JM, Sutton BJ, Beavil AJ Sci Rep. 2017 Mar 31;7:45533. doi: 10.1038/srep45533. PMID:28361904<ref>PMID:28361904</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5lgk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:27, 5 April 2017

OCA — Wed, 05 Apr 2017 13:27:55 GMT

←Older revision		Revision as of 13:27, 5 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5lgk is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the human IgE-Fc bound to its B cell receptor derCD23==
-		+	<StructureSection load='5lgk' size='340' side='right' caption='[[5lgk]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lgk]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LGK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgk OCA], [http://pdbe.org/5lgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lgk RCSB], [http://www.ebi.ac.uk/pdbsum/5lgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgk ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN]] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dhaliwal, B]]
		+	[[Category: Pang, M O.Y]]
		+	[[Category: Sutton, B J]]
		+	[[Category: Antibody receptor]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold lectin]]

OCA at 13:29, 26 July 2016

OCA — Tue, 26 Jul 2016 13:29:00 GMT

←Older revision		Revision as of 13:29, 26 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lgk is ON HOLD	+	The entry 5lgk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5lgk" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 10:06:59 GMT

Protected "5lgk" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lgk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 14 Jul 2016 10:06:58 GMT

New page: '''Unreleased structure''' The entry 5lgk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5lgk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]