5lgo - Revision history

OCA at 18:24, 18 October 2023

OCA — Wed, 18 Oct 2023 18:24:27 GMT

←Older revision		Revision as of 18:24, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5lgo' size='340' side='right'caption='[[5lgo]], [[Resolution\|resolution]] 1.12Å' scene=''>		<StructureSection load='5lgo' size='340' side='right'caption='[[5lgo]], [[Resolution\|resolution]] 1.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lgo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LGO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lgo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LGO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6VZ:(2~{S},4~{S})-1-[4-(AMINOMETHYL)-3-METHOXY-PHENYL]CARBONYL-4-[4-(2-CYCLOPROPYLETHOXY)-6,8-DIHYDRO-5~{H}-PYRIDO[3,4-D]PYRIMIDIN-7-YL]-~{N}-METHYL-PYRROLIDINE-2-CARBOXAMIDE'>6VZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.12Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VZ:(2~{S},4~{S})-1-[4-(AMINOMETHYL)-3-METHOXY-PHENYL]CARBONYL-4-[4-(2-CYCLOPROPYLETHOXY)-6,8-DIHYDRO-5~{H}-PYRIDO[3,4-D]PYRIMIDIN-7-YL]-~{N}-METHYL-PYRROLIDINE-2-CARBOXAMIDE'>6VZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgo OCA], [~~http~~://pdbe.org/5lgo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lgo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lgo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgo OCA], [https://pdbe.org/5lgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lgo RCSB], [https://www.ebi.ac.uk/pdbsum/5lgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5lgo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lgo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin 3D structures\|Trypsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 28:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trypsin]]~~	+	[[Category: D'Arcy A]]
-	~~[[Category:~~ Arcy, A D]]	+	[[Category: Schiering N]]
-	[[Category: Schiering, N]]	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Pancreatitis]]~~	+
-	~~[[Category: S1 protease~~]]	+

OCA at 06:28, 16 October 2019

OCA — Wed, 16 Oct 2019 06:28:39 GMT

←Older revision		Revision as of 06:28, 16 October 2019
Line 1:		Line 1:

	==Trypsin inhibitors for the treatment of pancreatitis - cpd 15==		==Trypsin inhibitors for the treatment of pancreatitis - cpd 15==
-	<StructureSection load='5lgo' size='340' side='right' caption='[[5lgo]], [[Resolution\|resolution]] 1.12Å' scene=''>	+	<StructureSection load='5lgo' size='340' side='right'caption='[[5lgo]], [[Resolution\|resolution]] 1.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LGO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LGO FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Trypsin]]		[[Category: Trypsin]]
	[[Category: Arcy, A D]]		[[Category: Arcy, A D]]

OCA at 16:11, 10 August 2016

OCA — Wed, 10 Aug 2016 16:11:01 GMT

←Older revision		Revision as of 16:11, 10 August 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lgo is ~~ON HOLD~~	+	==Trypsin inhibitors for the treatment of pancreatitis - cpd 15==
		+	<StructureSection load='5lgo' size='340' side='right' caption='[[5lgo]], [[Resolution\|resolution]] 1.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lgo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LGO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6VZ:(2~{S},4~{S})-1-[4-(AMINOMETHYL)-3-METHOXY-PHENYL]CARBONYL-4-[4-(2-CYCLOPROPYLETHOXY)-6,8-DIHYDRO-5~{H}-PYRIDO[3,4-D]PYRIMIDIN-7-YL]-~{N}-METHYL-PYRROLIDINE-2-CARBOXAMIDE'>6VZ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lgo OCA], [http://pdbe.org/5lgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lgo RCSB], [http://www.ebi.ac.uk/pdbsum/5lgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lgo ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proline-based trypsin inhibitors occupying the S1-S2-S1' region were identified by an HTS screening campaign. It was discovered that truncation of the P1' moiety and appropriate extension into the S4 region led to highly potent trypsin inhibitors with excellent selectivity against related serine proteases and a favorable hERG profile.

-	~~Authors: Schiering~~, N., ~~D'Arcy~~, A.	+	Trypsin inhibitors for the treatment of pancreatitis.,Brandl T, Simic O, Skaanderup PR, Namoto K, Berst F, Ehrhardt C, Schiering N, Mueller I, Woelcke J Bioorg Med Chem Lett. 2016 Jul 17. pii: S0960-894X(16)30742-9. doi:, 10.1016/j.bmcl.2016.07.029. PMID:27476144<ref>PMID:27476144</ref>

-	~~Description: Trypsin inhibitors for~~ the ~~treatment~~ of ~~pancreatitis~~ -~~cpd 15~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: D'Arcy, A]]	+	<div class="pdbe-citations 5lgo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Trypsin]]
		+	[[Category: Arcy, A D]]
	[[Category: Schiering, N]]		[[Category: Schiering, N]]
		+	[[Category: Complex]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Pancreatitis]]
		+	[[Category: S1 protease]]

OCA: Protected "5lgo" [edit=sysop:move=sysop]

OCA — Thu, 14 Jul 2016 10:07:15 GMT

Protected "5lgo" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:07, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lgo is ON HOLD Authors: Schiering, N., D'Arcy, A. Description: Trypsin inhibitors for the treatment of pancreatitis -cpd 15 [[Category: Unreleased...

OCA — Thu, 14 Jul 2016 10:07:14 GMT

New page: '''Unreleased structure''' The entry 5lgo is ON HOLD Authors: Schiering, N., D'Arcy, A. Description: Trypsin inhibitors for the treatment of pancreatitis -cpd 15 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5lgo is ON HOLD

Authors: Schiering, N., D'Arcy, A.

Description: Trypsin inhibitors for the treatment of pancreatitis -cpd 15
[[Category: Unreleased Structures]]
[[Category: D'Arcy, A]]
[[Category: Schiering, N]]