5lia - Revision history

OCA at 18:27, 18 October 2023

OCA — Wed, 18 Oct 2023 18:27:06 GMT

←Older revision		Revision as of 18:27, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5lia' size='340' side='right'caption='[[5lia]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='5lia' size='340' side='right'caption='[[5lia]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LIA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN~~</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Enpp2, Npps2, Pdnp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [https://pdbe.org/5lia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [https://www.ebi.ac.uk/pdbsum/5lia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [~~http~~://pdbe.org/5lia PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lia PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.	+	[https://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE] Note=May contribute to obesity.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>	+	[https://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Cheasty, A]]	+	[[Category: Cheasty A]]
-	[[Category: Owen, P]]	+	[[Category: Owen P]]
-	[[Category: Pang, L]]	+	[[Category: Pang L]]
-	[[Category: Raynham, T]]	+	[[Category: Raynham T]]
-	[[Category: Shah, P]]	+	[[Category: Shah P]]
-	[[Category: Turnbull~~, A P]]~~	+	[[Category: Turnbull AP]]
-	~~[[Category: Autotaxin]]~~	+
-	~~[[Category: Enpp2]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lysophospholipase d~~]]	+

OCA at 10:38, 12 August 2020

OCA — Wed, 12 Aug 2020 10:38:14 GMT

←Older revision		Revision as of 10:38, 12 August 2020
Line 1:		Line 1:

	==Crystal structure of murine autotaxin in complex with a small molecule inhibitor==		==Crystal structure of murine autotaxin in complex with a small molecule inhibitor==
-	<StructureSection load='5lia' size='340' side='right' caption='[[5lia]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='5lia' size='340' side='right'caption='[[5lia]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LIA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN~~</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Enpp2, Npps2, Pdnp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [http://pdbe.org/5lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [http://www.ebi.ac.uk/pdbsum/5lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [http://pdbe.org/5lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [http://www.ebi.ac.uk/pdbsum/5lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5lia" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lia" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures\|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]		[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Cheasty, A]]		[[Category: Cheasty, A]]
	[[Category: Owen, P]]		[[Category: Owen, P]]

OCA at 19:56, 9 December 2016

OCA — Fri, 09 Dec 2016 19:56:39 GMT

←Older revision		Revision as of 19:56, 9 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lia is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of murine autotaxin in complex with a small molecule inhibitor==
		+	<StructureSection load='5lia' size='340' side='right' caption='[[5lia]], [[Resolution\|resolution]] 1.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LIA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [http://pdbe.org/5lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [http://www.ebi.ac.uk/pdbsum/5lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The autotoxin-lysophosphatidic acid (ATX-LPA) axis has been implicated in several disease conditions including inflammation, fibrosis and cancer. This makes ATX an attractive drug target and its inhibition may lead to useful therapeutic agents. Through a high throughput screen (HTS) we identified a series of small molecule inhibitors of ATX which have subsequently been optimized for potency, selectivity and developability properties. This has delivered drug-like compounds such as 9v (CRT0273750) which modulate LPA levels in plasma and are suitable for in vivo studies. X-ray crystallography has revealed that these compounds have an unexpected binding mode in that they do not interact with the active site zinc ions but instead occupy the hydrophobic LPC pocket extending from the active of ATX together with the occupying the LPA 'exit' channel.

-	~~Authors: Turnbull, A.P~~., Shah, P., Cheasty, A., ~~Raynham~~, T., ~~Pang~~, L., Owen, P.	+	Discovery of potent inhibitors of the lysophospholipase autotaxin.,Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H Bioorg Med Chem Lett. 2016 Oct 14. pii: S0960-894X(16)31064-2. doi:, 10.1016/j.bmcl.2016.10.036. PMID:27780639<ref>PMID:27780639</ref>

-	~~Description: Crystal structure of murine autotaxin in complex with~~ a ~~small molecule inhibitor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Shah, P~~]]	+	<div class="pdbe-citations 5lia" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Raynham~~, T]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
		+	[[Category: Cheasty, A]]
	[[Category: Owen, P]]		[[Category: Owen, P]]
	[[Category: Pang, L]]		[[Category: Pang, L]]
-	[[Category: ~~Cheasty~~, A]]	+	[[Category: Raynham, T]]
-	[[Category: Turnbull, A.P]]	+	[[Category: Shah, P]]
		+	[[Category: Turnbull, A P]]
		+	[[Category: Autotaxin]]
		+	[[Category: Enpp2]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lysophospholipase d]]

OCA at 14:55, 9 September 2016

OCA — Fri, 09 Sep 2016 14:55:19 GMT

←Older revision		Revision as of 14:55, 9 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lia is ON HOLD	+	The entry 5lia is ON HOLD until Paper Publication

-	Authors: Turnbull, A.P., Shah, P., Cheasty, A~~., Foxton, C., Farooq, M~~., Raynham, T~~., Gutierrez, I.F., Lejeune, A., Pritchard, M~~., Pang, L., Owen, P~~., Boyd, S.M., Boakes, A., Jordan, A., Hamilton, N., Hitchin, J., Stockley, M., MacDonald, E., Quesada, M.J., Trivier, E., Skeete, J., Ovaa, H., Moolenaar, W~~.	+	Authors: Turnbull, A.P., Shah, P., Cheasty, A., Raynham, T., Pang, L., Owen, P.

	Description: Crystal structure of murine autotaxin in complex with a small molecule inhibitor		Description: Crystal structure of murine autotaxin in complex with a small molecule inhibitor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Shah, P]]		[[Category: Shah, P]]
-	[[Category: Lejeune, A]]
	[[Category: Raynham, T]]		[[Category: Raynham, T]]
-	[[Category: Foxton, C]]
-	[[Category: Jordan, A]]
-	[[Category: Pritchard, M]]
-	[[Category: Hitchin, J]]
-	[[Category: Moolenaar, W]]
-	[[Category: Boakes, A]]
	[[Category: Owen, P]]		[[Category: Owen, P]]
-	[[Category: Hamilton, N]]
-	[[Category: Farooq, M]]
	[[Category: Pang, L]]		[[Category: Pang, L]]
-	[[Category: Stockley, M]]
-	[[Category: Ovaa, H]]
-	[[Category: Trivier, E]]
-	[[Category: Quesada, M.J]]
-	[[Category: Boyd, S.M]]
	[[Category: Cheasty, A]]		[[Category: Cheasty, A]]
	[[Category: Turnbull, A.P]]		[[Category: Turnbull, A.P]]
-	[[Category: Skeete, J]]
-	[[Category: Gutierrez, I.F]]
-	[[Category: Macdonald, E]]

OCA: Protected "5lia" [edit=sysop:move=sysop]

OCA — Tue, 26 Jul 2016 13:34:32 GMT

Protected "5lia" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:34, 26 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lia is ON HOLD Authors: Turnbull, A.P., Shah, P., Cheasty, A., Foxton, C., Farooq, M., Raynham, T., Gutierrez, I.F., Lejeune, A., Pritchard, M., Pa...

OCA — Tue, 26 Jul 2016 13:34:31 GMT

New page: '''Unreleased structure''' The entry 5lia is ON HOLD Authors: Turnbull, A.P., Shah, P., Cheasty, A., Foxton, C., Farooq, M., Raynham, T., Gutierrez, I.F., Lejeune, A., Pritchard, M., Pa...

New page

'''Unreleased structure'''

The entry 5lia is ON HOLD

Authors: Turnbull, A.P., Shah, P., Cheasty, A., Foxton, C., Farooq, M., Raynham, T., Gutierrez, I.F., Lejeune, A., Pritchard, M., Pang, L., Owen, P., Boyd, S.M., Boakes, A., Jordan, A., Hamilton, N., Hitchin, J., Stockley, M., MacDonald, E., Quesada, M.J., Trivier, E., Skeete, J., Ovaa, H., Moolenaar, W.

Description: Crystal structure of murine autotaxin in complex with a small molecule inhibitor
[[Category: Unreleased Structures]]
[[Category: Shah, P]]
[[Category: Lejeune, A]]
[[Category: Raynham, T]]
[[Category: Foxton, C]]
[[Category: Jordan, A]]
[[Category: Pritchard, M]]
[[Category: Hitchin, J]]
[[Category: Moolenaar, W]]
[[Category: Boakes, A]]
[[Category: Owen, P]]
[[Category: Hamilton, N]]
[[Category: Farooq, M]]
[[Category: Pang, L]]
[[Category: Stockley, M]]
[[Category: Ovaa, H]]
[[Category: Trivier, E]]
[[Category: Quesada, M.J]]
[[Category: Boyd, S.M]]
[[Category: Cheasty, A]]
[[Category: Turnbull, A.P]]
[[Category: Skeete, J]]
[[Category: Gutierrez, I.F]]
[[Category: Macdonald, E]]