5lir - Revision history

OCA at 18:28, 18 October 2023

OCA — Wed, 18 Oct 2023 18:28:03 GMT

←Older revision		Revision as of 18:28, 18 October 2023
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	<StructureSection load='5lir' size='340' side='right'caption='[[5lir]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='5lir' size='340' side='right'caption='[[5lir]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lir]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lir]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LIR FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">yhbL, STM3327 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [https://pdbe.org/5lir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [https://www.ebi.ac.uk/pdbsum/5lir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [~~http~~://pdbe.org/5lir PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lir PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8ZLR6_SALTY Q8ZLR6_SALTY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus typhimurium loeffler 1892]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mandel, M~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-	[[Category: ~~Schneider, S~~]]	+	[[Category: Mandel M]]
-	[[Category: ~~Sieber,~~ S A]]	+	[[Category: Schneider S]]
-	[[Category: ~~Rossmann fold class i glutamine amidotransferase-like]]~~	+	[[Category: Sieber SA]]
-	~~[[Category: Transferase~~]]	+

OCA at 10:38, 12 August 2020

OCA — Wed, 12 Aug 2020 10:38:33 GMT

←Older revision		Revision as of 10:38, 12 August 2020
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	==Structure of the SALTY Sigma cross-reacting protein 27A (SCRP-27A) from Salmonella typhimurium==		==Structure of the SALTY Sigma cross-reacting protein 27A (SCRP-27A) from Salmonella typhimurium==
-	<StructureSection load='5lir' size='340' side='right' caption='[[5lir]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='5lir' size='340' side='right'caption='[[5lir]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LIR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LIR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [http://pdbe.org/5lir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [http://www.ebi.ac.uk/pdbsum/5lir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yhbL, STM3327 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [http://pdbe.org/5lir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [http://www.ebi.ac.uk/pdbsum/5lir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus typhimurium loeffler 1892]]
		+	[[Category: Large Structures]]
	[[Category: Mandel, M]]		[[Category: Mandel, M]]
	[[Category: Schneider, S]]		[[Category: Schneider, S]]

OCA at 20:08, 9 December 2016

OCA — Fri, 09 Dec 2016 20:08:44 GMT

←Older revision		Revision as of 20:08, 9 December 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [http://pdbe.org/5lir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [http://www.ebi.ac.uk/pdbsum/5lir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [http://pdbe.org/5lir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [http://www.ebi.ac.uk/pdbsum/5lir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones and explore their antibiotic activity against several pathogenic bacteria. A compound with activity against Salmonella Typhimurium was identified, and the target enzymes were unraveled by quantitative chemical proteomics. Importantly, two protein hits were linked to bacterial stress response, and corresponding assays revealed an elevated susceptibility to reactive oxygen species upon compound treatment. The consolidated inhibition of these targets provides a rationale for antibacterial activity and highlights epoxycyclohexenones as natural product scaffolds with suitable properties for killing Gram-negative Salmonella.
		+
		+	Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response.,Mandl FA, Kirsch VC, Ugur I, Kunold E, Vomacka J, Fetzer C, Schneider S, Richter K, Fuchs TM, Antes I, Sieber SA Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14852-14857. doi:, 10.1002/anie.201607338. Epub 2016 Oct 26. PMID:27782347<ref>PMID:27782347</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5lir" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:36, 14 September 2016

OCA — Wed, 14 Sep 2016 15:36:36 GMT

←Older revision		Revision as of 15:36, 14 September 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5lir is ~~ON HOLD~~	+	==Structure of the SALTY Sigma cross-reacting protein 27A (SCRP-27A) from Salmonella typhimurium==
-		+	<StructureSection load='5lir' size='340' side='right' caption='[[5lir]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lir]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LIR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lir OCA], [http://pdbe.org/5lir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lir RCSB], [http://www.ebi.ac.uk/pdbsum/5lir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lir ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mandel, M]]
		+	[[Category: Schneider, S]]
		+	[[Category: Sieber, S A]]
		+	[[Category: Rossmann fold class i glutamine amidotransferase-like]]
		+	[[Category: Transferase]]

OCA: Protected "5lir" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2016 13:59:51 GMT

Protected "5lir" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:59, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lir is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Jul 2016 13:59:50 GMT

New page: '''Unreleased structure''' The entry 5lir is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5lir is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]