5lji - Revision history

OCA at 18:29, 18 October 2023

OCA — Wed, 18 Oct 2023 18:29:40 GMT

←Older revision		Revision as of 18:29, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5lji' size='340' side='right'caption='[[5lji]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='5lji' size='340' side='right'caption='[[5lji]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lji]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LJI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">AWW74_08705 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [https://pdbe.org/5lji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [https://www.ebi.ac.uk/pdbsum/5lji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [~~http~~://pdbe.org/5lji PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lji PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8DPG4_STRR6 Q8DPG4_STRR6] Low-potential electron donor to a number of redox enzymes.[RuleBase:RU367037]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hurtado-Guerrero, R]]
-	[[Category: Rodriguez-Cardenas, A]]
-	[[Category: Rojas, A L]]
-	[[Category: Sancho, J]]
-	[[Category: Velazquez-Campoy, A]]
-	[[Category: Drug target]]
-	[[Category: Flavodoxin]]
-	[[Category: Fmn binding]]
-	[[Category: Oxidoreductase]]
-	[[Category: Protein stability]]
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
		+	[[Category: Hurtado-Guerrero R]]
		+	[[Category: Rodriguez-Cardenas A]]
		+	[[Category: Rojas AL]]
		+	[[Category: Sancho J]]
		+	[[Category: Velazquez-Campoy A]]

OCA at 10:39, 12 August 2020

OCA — Wed, 12 Aug 2020 10:39:38 GMT

←Older revision		Revision as of 10:39, 12 August 2020
Line 1:		Line 1:

	==Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target==		==Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target==
-	<StructureSection load='5lji' size='340' side='right' caption='[[5lji]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='5lji' size='340' side='right'caption='[[5lji]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lji]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LJI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [http://pdbe.org/5lji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [http://www.ebi.ac.uk/pdbsum/5lji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AWW74_08705 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [http://pdbe.org/5lji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [http://www.ebi.ac.uk/pdbsum/5lji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5lji" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lji" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Flavodoxin 3D structures\|Flavodoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]
	[[Category: Rodriguez-Cardenas, A]]		[[Category: Rodriguez-Cardenas, A]]

OCA at 09:15, 3 October 2016

OCA — Mon, 03 Oct 2016 09:15:21 GMT

←Older revision		Revision as of 09:15, 3 October 2016
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [http://pdbe.org/5lji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [http://www.ebi.ac.uk/pdbsum/5lji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [http://pdbe.org/5lji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [http://www.ebi.ac.uk/pdbsum/5lji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pneumoniae (Sp) strain TIGR4 is a virulent, encapsulated serotype that causes bacteremia, otitis media, meningitis and pneumonia. Increased bacterial resistance and limited efficacy of the available vaccine to some serotypes complicate the treatment of diseases associated to this microorganism. Flavodoxins are bacterial proteins involved in several important metabolic pathways. The Sp flavodoxin (Spfld) gene was recently reported to be essential for the establishment of meningitis in a rat model, which makes SpFld a potential drug target. To facilitate future pharmacological studies, we have cloned and expressed SpFld in E. coli and we have performed an extensive structural and biochemical characterization of both the apo form and its active complex with the FMN cofactor. SpFld is a short-chain flavodoxin containing 146 residues. Unlike the well-characterized long-chain apoflavodoxins, the Sp apoprotein displays a simple two-state thermal unfolding equilibrium and binds FMN with moderate affinity. The X-ray structures of the apo and holo forms of SpFld differ at the FMN binding site, where substantial rearrangement of residues at the 91-100 loop occurs to permit cofactor binding. This work will set up the basis for future studies aiming at discovering new potential drugs to treat S. pneumoniae diseases through the inhibition of SpFld.
		+
		+	Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.,Rodriguez-Cardenas A, Rojas AL, Conde-Gimenez M, Velazquez-Campoy A, Hurtado-Guerrero R, Sancho J PLoS One. 2016 Sep 20;11(9):e0161020. doi: 10.1371/journal.pone.0161020., eCollection 2016. PMID:27649488<ref>PMID:27649488</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5lji" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:03, 10 September 2016

OCA — Sat, 10 Sep 2016 14:03:31 GMT

←Older revision		Revision as of 14:03, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lji ~~is ON HOLD until Paper Publication~~	+	==Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target==
-		+	<StructureSection load='5lji' size='340' side='right' caption='[[5lji]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~Authors~~: ~~Rodriguez~~-~~Cardenas, A~~.~~, Rojas, A~~.L.~~, Velazquez~~-~~Campoy~~, A., ~~Hurtado~~-~~Guerrero~~, R., ~~Sancho~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lji]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LJI FirstGlance]. <br>
-	~~Description: Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lji OCA], [http://pdbe.org/5lji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lji RCSB], [http://www.ebi.ac.uk/pdbsum/5lji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lji ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hurtado-Guerrero, R]]
	[[Category: Rodriguez-Cardenas, A]]		[[Category: Rodriguez-Cardenas, A]]
		+	[[Category: Rojas, A L]]
	[[Category: Sancho, J]]		[[Category: Sancho, J]]
	[[Category: Velazquez-Campoy, A]]		[[Category: Velazquez-Campoy, A]]
-	[[Category: ~~Hurtado-Guerrero, R~~]]	+	[[Category: Drug target]]
-	[[Category: ~~Rojas, A.L~~]]	+	[[Category: Flavodoxin]]
		+	[[Category: Fmn binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Protein stability]]
		+	[[Category: Streptococcus pneumoniae]]

OCA: Protected "5lji" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2016 14:01:17 GMT

Protected "5lji" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:01, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5lji is ON HOLD until Paper Publication Authors: Rodriguez-Cardenas, A., Rojas, A.L., Velazquez-Campoy, A., Hurtado-Guerrero, R., Sancho, J. Descri...

OCA — Wed, 27 Jul 2016 14:01:15 GMT

New page: '''Unreleased structure''' The entry 5lji is ON HOLD until Paper Publication Authors: Rodriguez-Cardenas, A., Rojas, A.L., Velazquez-Campoy, A., Hurtado-Guerrero, R., Sancho, J. Descri...

New page

'''Unreleased structure'''

The entry 5lji is ON HOLD until Paper Publication

Authors: Rodriguez-Cardenas, A., Rojas, A.L., Velazquez-Campoy, A., Hurtado-Guerrero, R., Sancho, J.

Description: Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target
[[Category: Unreleased Structures]]
[[Category: Rodriguez-Cardenas, A]]
[[Category: Sancho, J]]
[[Category: Velazquez-Campoy, A]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Rojas, A.L]]