5lou - Revision history

OCA at 18:38, 18 October 2023

OCA — Wed, 18 Oct 2023 18:38:01 GMT

←Older revision		Revision as of 18:38, 18 October 2023
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	<StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LOU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NUDT22, PP11246 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [~~http~~://pdbe.org/5lou PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lou PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [https://pdbe.org/5lou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [https://www.ebi.ac.uk/pdbsum/5lou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NUD22_HUMAN NUD22_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carter, M]]	+	[[Category: Carter M]]
-	[[Category: Stenmark, P]]	+	[[Category: Stenmark P]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nudix~~]]	+

OCA at 06:53, 27 March 2019

OCA — Wed, 27 Mar 2019 06:53:37 GMT

←Older revision		Revision as of 06:53, 27 March 2019
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	==human NUDT22==		==human NUDT22==
-	<StructureSection load='5lou' size='340' side='right' caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5lou' size='340' side='right'caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human NUDT22 belongs to the diverse NUDIX family of proteins, but has, until now, remained uncharacterized. Here we show that human NUDT22 is a Mg(2+)-dependent UDP-glucose and UDP-galactose hydrolase, producing UMP and glucose 1-phosphate or galactose 1-phosphate. We present the structure of human NUDT22 alone and in a complex with the substrate UDP-glucose. These structures reveal a partially conserved NUDIX fold domain preceded by a unique N-terminal domain responsible for UDP moiety binding and recognition. The NUDIX domain of NUDT22 contains a modified NUDIX box identified using structural analysis and confirmed through functional analysis of mutants. Human NUDT22's distinct structure and function as a UDP-carbohydrate hydrolase establish a unique NUDIX protein subfamily.
		+
		+	Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.,Carter M, Jemth AS, Carreras-Puigvert J, Herr P, Martinez Carranza M, Vallin KSA, Throup A, Helleday T, Stenmark P Structure. 2018 Feb 6;26(2):295-303.e6. doi: 10.1016/j.str.2018.01.004. PMID:29413322<ref>PMID:29413322</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5lou" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Carter, M]]		[[Category: Carter, M]]
	[[Category: Stenmark, P]]		[[Category: Stenmark, P]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nudix]]		[[Category: Nudix]]

OCA at 07:18, 21 February 2019

OCA — Thu, 21 Feb 2019 07:18:54 GMT

←Older revision		Revision as of 07:18, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='5lou' size='340' side='right' caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5lou' size='340' side='right' caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NUDT22, PP11246 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Carter, M]]		[[Category: Carter, M]]
	[[Category: Stenmark, P]]		[[Category: Stenmark, P]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nudix]]		[[Category: Nudix]]

OCA at 05:18, 6 October 2017

OCA — Fri, 06 Oct 2017 05:18:31 GMT

←Older revision		Revision as of 05:18, 6 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lou is ~~ON HOLD until Paper Publication~~	+	==human NUDT22==
-		+	<StructureSection load='5lou' size='340' side='right' caption='[[5lou]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Carter~~, M., ~~Stenmark~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lou]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOU FirstGlance]. <br>
-	~~Description: human NUDT22~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lou OCA], [http://pdbe.org/5lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lou RCSB], [http://www.ebi.ac.uk/pdbsum/5lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lou ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carter, M]]
	[[Category: Stenmark, P]]		[[Category: Stenmark, P]]
-	[[Category: ~~Carter, M~~]]	+	[[Category: Hydrolase]]
		+	[[Category: Nudix]]

OCA at 16:01, 9 December 2016

OCA — Fri, 09 Dec 2016 16:01:01 GMT

←Older revision		Revision as of 16:01, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lou is ON HOLD	+	The entry 5lou is ON HOLD until Paper Publication

	Authors: Carter, M., Stenmark, P.		Authors: Carter, M., Stenmark, P.

OCA: Protected "5lou" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:07:47 GMT

Protected "5lou" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:07, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lou is ON HOLD Authors: Carter, M., Stenmark, P. Description: human NUDT22 Category: Unreleased Structures Category: Stenmark, P [[Categor...

OCA — Fri, 09 Sep 2016 15:07:46 GMT

New page: '''Unreleased structure''' The entry 5lou is ON HOLD Authors: Carter, M., Stenmark, P. Description: human NUDT22 Category: Unreleased Structures Category: Stenmark, P [[Categor...

New page

'''Unreleased structure'''

The entry 5lou is ON HOLD

Authors: Carter, M., Stenmark, P.

Description: human NUDT22
[[Category: Unreleased Structures]]
[[Category: Stenmark, P]]
[[Category: Carter, M]]