5lpu - Revision history

OCA at 18:40, 18 October 2023

OCA — Wed, 18 Oct 2023 18:40:43 GMT

←Older revision		Revision as of 18:40, 18 October 2023
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	<StructureSection load='5lpu' size='340' side='right'caption='[[5lpu]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5lpu' size='340' side='right'caption='[[5lpu]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lpu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LPU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpu OCA], [~~http~~://pdbe.org/5lpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpu OCA], [https://pdbe.org/5lpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lpu RCSB], [https://www.ebi.ac.uk/pdbsum/5lpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN]] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.	+	[https://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ecsedi, P]]	+	[[Category: Ecsedi P]]
-	[[Category: Gogl, G]]	+	[[Category: Gogl G]]
-	[[Category: Kiss, B]]	+	[[Category: Kiss B]]
-	[[Category: Nyitray, L]]	+	[[Category: Nyitray L]]
-	~~[[Category: Calcium-binding protein]]~~	+
-	~~[[Category: Protein-protein complex~~]]	+

OCA at 10:45, 12 August 2020

OCA — Wed, 12 Aug 2020 10:45:59 GMT

←Older revision		Revision as of 10:45, 12 August 2020
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	==Crystal structure of Annexin A2 complexed with S100A4==		==Crystal structure of Annexin A2 complexed with S100A4==
-	<StructureSection load='5lpu' size='340' side='right' caption='[[5lpu]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5lpu' size='340' side='right'caption='[[5lpu]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lpu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lpu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LPU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpu OCA], [http://pdbe.org/5lpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpu RCSB], [http://www.ebi.ac.uk/pdbsum/5lpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpu OCA], [http://pdbe.org/5lpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpu RCSB], [http://www.ebi.ac.uk/pdbsum/5lpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Annexin 3D structures\|Annexin 3D structures]]
		+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ecsedi, P]]		[[Category: Ecsedi, P]]
	[[Category: Gogl, G]]		[[Category: Gogl, G]]

OCA at 06:27, 16 November 2017

OCA — Thu, 16 Nov 2017 06:27:43 GMT

←Older revision		Revision as of 06:27, 16 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:28, 7 October 2017

OCA — Sat, 07 Oct 2017 12:28:29 GMT

←Older revision		Revision as of 12:28, 7 October 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 protein\|S100 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:10, 9 August 2017

OCA — Wed, 09 Aug 2017 09:10:51 GMT

←Older revision		Revision as of 09:10, 9 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5lpu is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Annexin A2 complexed with S100A4==
		+	<StructureSection load='5lpu' size='340' side='right' caption='[[5lpu]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lpu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LPU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpu OCA], [http://pdbe.org/5lpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpu RCSB], [http://www.ebi.ac.uk/pdbsum/5lpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN]] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Annexin A2 (ANXA2) has a versatile role in membrane-associated functions including membrane aggregation, endo- and exocytosis, and it is regulated by post-translational modifications and protein-protein interactions through the unstructured N-terminal domain (NTD). Our sequence analysis revealed a short motif responsible for clamping the NTD to the C-terminal core domain (CTD). Structural studies indicated that the flexibility of the NTD and CTD are interrelated and oppositely regulated by Tyr24 phosphorylation and Ser26Glu phosphomimicking mutation. The crystal structure of the ANXA2-S100A4 complex showed that asymmetric binding of S100A4 induces dislocation of the NTD from the CTD and, similar to the Ser26Glu mutation, unmasks the concave side of ANXA2. In contrast, pTyr24 anchors the NTD to the CTD and hampers the membrane-bridging function. This inhibition can be restored by S100A4 and S100A10 binding. Based on our results we provide a structural model for regulation of ANXA2-mediated membrane aggregation by NTD phosphorylation and S100 binding.

-	~~Authors: Ecsedi~~, P., ~~Gogl~~, G., ~~Kiss~~, B., ~~Nyitray~~, L.	+	Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.,Ecsedi P, Kiss B, Gogl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vertessy B, Jeszenoi N, Hetenyi C, Schlosser G, Katona G, Nyitray L Structure. 2017 Aug 1;25(8):1195-1207.e5. doi: 10.1016/j.str.2017.06.001. Epub, 2017 Jun 29. PMID:28669632<ref>PMID:28669632</ref>

-	~~Description: Crystal structure~~ of ~~Annexin A2 complexed with S100A4~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5lpu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ecsedi, P]]
	[[Category: Gogl, G]]		[[Category: Gogl, G]]
-	[[Category: Nyitray, L]]
	[[Category: Kiss, B]]		[[Category: Kiss, B]]
-	[[Category: ~~Ecsedi~~, P]]	+	[[Category: Nyitray, L]]
		+	[[Category: Calcium-binding protein]]
		+	[[Category: Protein-protein complex]]

OCA at 10:48, 9 March 2017

OCA — Thu, 09 Mar 2017 10:48:25 GMT

←Older revision		Revision as of 10:48, 9 March 2017
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Gogl, G]]		[[Category: Gogl, G]]
-	[[Category: Kiss, B]]
	[[Category: Nyitray, L]]		[[Category: Nyitray, L]]
		+	[[Category: Kiss, B]]
	[[Category: Ecsedi, P]]		[[Category: Ecsedi, P]]

OCA: Protected "5lpu" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:10:24 GMT

Protected "5lpu" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:10, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lpu is ON HOLD until Paper Publication Authors: Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L. Description: Crystal structure of Annexin A2 complexed...

OCA — Fri, 09 Sep 2016 15:10:22 GMT

New page: '''Unreleased structure''' The entry 5lpu is ON HOLD until Paper Publication Authors: Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L. Description: Crystal structure of Annexin A2 complexed...

New page

'''Unreleased structure'''

The entry 5lpu is ON HOLD until Paper Publication

Authors: Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L.

Description: Crystal structure of Annexin A2 complexed with S100A4
[[Category: Unreleased Structures]]
[[Category: Gogl, G]]
[[Category: Kiss, B]]
[[Category: Nyitray, L]]
[[Category: Ecsedi, P]]