5lq8 - Revision history

OCA at 18:41, 18 October 2023

OCA — Wed, 18 Oct 2023 18:41:10 GMT

←Older revision		Revision as of 18:41, 18 October 2023
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	<StructureSection load='5lq8' size='340' side='right'caption='[[5lq8]], [[Resolution\|resolution]] 1.52Å' scene=''>		<StructureSection load='5lq8' size='340' side='right'caption='[[5lq8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lq8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQ8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochlorococcus_marinus_str._MIT_9301 Prochlorococcus marinus str. MIT 9301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LQ8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GB:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>GB</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.52Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5lq5\|5lq5]], [[5jvb\|5jvb]], [[5lq1\|5lq1]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GB:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>GB</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lq8 OCA], [~~http~~://pdbe.org/5lq8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lq8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lq8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lq8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lq8 OCA], [https://pdbe.org/5lq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lq8 RCSB], [https://www.ebi.ac.uk/pdbsum/5lq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PHND1_PROM0 PHND1_PROM0]] Probably part of the ABC transporter complex PhnD1C1E1. Binds strongly to inorganic phosphite and with very weak affinities to methylphosphonate (MPn) and phosphate.<ref>PMID:22011717</ref>	+	[https://www.uniprot.org/uniprot/PHND1_PROM0 PHND1_PROM0] Probably part of the ABC transporter complex PhnD1C1E1. Binds strongly to inorganic phosphite and with very weak affinities to methylphosphonate (MPn) and phosphate.<ref>PMID:22011717</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Adams, N B~~.P]]	+	[[Category: Prochlorococcus marinus str. MIT 9301]]
-	[[Category: Bibby~~, T S~~]]	+	[[Category: Adams NBP]]
-	[[Category: Bisson, C]]	+	[[Category: Bibby TS]]
-	[[Category: Hitchcock, A]]	+	[[Category: Bisson C]]
-	[[Category: Hunter~~, C N~~]]	+	[[Category: Hitchcock A]]
-	[[Category: Polyviou, D]]	+	[[Category: Hunter CN]]
-	~~[[Category: Abc-transporter]]~~	+	[[Category: Polyviou D]]
-	~~[[Category: Methylphosphonate]]~~	+
-	~~[[Category: Periplasmic binding protein]]~~	+
-	~~[[Category: Prochlorococcus~~]]	+

OCA at 10:46, 12 August 2020

OCA — Wed, 12 Aug 2020 10:46:38 GMT

←Older revision		Revision as of 10:46, 12 August 2020
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	==1.52 A resolution structure of PhnD1 from Prochlorococcus marinus (MIT 9301) in complex with methylphosphonate==		==1.52 A resolution structure of PhnD1 from Prochlorococcus marinus (MIT 9301) in complex with methylphosphonate==
-	<StructureSection load='5lq8' size='340' side='right' caption='[[5lq8]], [[Resolution\|resolution]] 1.52Å' scene=''>	+	<StructureSection load='5lq8' size='340' side='right'caption='[[5lq8]], [[Resolution\|resolution]] 1.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lq8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LQ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lq8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LQ8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GB:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>GB</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GB:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>GB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lq5\|5lq5]], [[5jvb\|5jvb]], [[5lq1\|5lq1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lq5\|5lq5]], [[5jvb\|5jvb]], [[5lq1\|5lq1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lq8 OCA], [http://pdbe.org/5lq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lq8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lq8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lq8 OCA], [http://pdbe.org/5lq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lq8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lq8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adams, N B.P]]		[[Category: Adams, N B.P]]
	[[Category: Bibby, T S]]		[[Category: Bibby, T S]]

OCA at 07:08, 6 December 2017

OCA — Wed, 06 Dec 2017 07:08:37 GMT

←Older revision		Revision as of 07:08, 6 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lq8 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==1.52 A resolution structure of PhnD1 from Prochlorococcus marinus (MIT 9301) in complex with methylphosphonate==
		+	<StructureSection load='5lq8' size='340' side='right' caption='[[5lq8]], [[Resolution\|resolution]] 1.52Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lq8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LQ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LQ8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GB:METHYLPHOSPHONIC+ACID+ESTER+GROUP'>GB</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lq5\|5lq5]], [[5jvb\|5jvb]], [[5lq1\|5lq1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lq8 OCA], [http://pdbe.org/5lq8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lq8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lq8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lq8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHND1_PROM0 PHND1_PROM0]] Probably part of the ABC transporter complex PhnD1C1E1. Binds strongly to inorganic phosphite and with very weak affinities to methylphosphonate (MPn) and phosphate.<ref>PMID:22011717</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inorganic phosphate is the major bioavailable form of the essential nutrient phosphorus. However, the concentration of phosphate in most natural habitats is low enough to limit microbial growth. Under phosphate-depleted conditions some bacteria utilise phosphite and hypophosphite as alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition from the environment is not fully understood. Here, we present crystal structures and ligand binding affinities of periplasmic binding proteins from bacterial phosphite and hypophosphite ATP-binding cassette transporters. We reveal that phosphite and hypophosphite specificity results from a combination of steric selection and the presence of a P-H...pi interaction between the ligand and a conserved aromatic residue in the ligand-binding pocket. The characterisation of high affinity and specific transporters has implications for the marine phosphorus redox cycle, and might aid the use of phosphite as an alternative phosphorus source in biotechnological, industrial and agricultural applications.

-	~~Authors~~:	+	The molecular basis of phosphite and hypophosphite recognition by ABC-transporters.,Bisson C, Adams NBP, Stevenson B, Brindley AA, Polyviou D, Bibby TS, Baker PJ, Hunter CN, Hitchcock A Nat Commun. 2017 Nov 23;8(1):1746. doi: 10.1038/s41467-017-01226-8. PMID:29170493<ref>PMID:29170493</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5lq8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adams, N B.P]]
		+	[[Category: Bibby, T S]]
		+	[[Category: Bisson, C]]
		+	[[Category: Hitchcock, A]]
		+	[[Category: Hunter, C N]]
		+	[[Category: Polyviou, D]]
		+	[[Category: Abc-transporter]]
		+	[[Category: Methylphosphonate]]
		+	[[Category: Periplasmic binding protein]]
		+	[[Category: Prochlorococcus]]

OCA: Protected "5lq8" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 15:11:07 GMT

Protected "5lq8" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:11, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lq8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Fri, 09 Sep 2016 15:11:06 GMT

New page: '''Unreleased structure''' The entry 5lq8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5lq8 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]