5lsa - Revision history

OCA at 18:44, 18 October 2023

OCA — Wed, 18 Oct 2023 18:44:25 GMT

←Older revision		Revision as of 18:44, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5lsa' size='340' side='right'caption='[[5lsa]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5lsa' size='340' side='right'caption='[[5lsa]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LSA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LSA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [https://pdbe.org/5lsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [https://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [~~http~~://pdbe.org/5lsa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/COMT_HUMAN COMT_HUMAN]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.	+	[https://www.uniprot.org/uniprot/COMT_HUMAN COMT_HUMAN] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
		+
		+	==See Also==
		+	*[[Catechol O-methyltransferase 3D structures\|Catechol O-methyltransferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Catechol O-methyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ehler, A]]	+	[[Category: Ehler A]]
-	[[Category: Lerner, C]]	+	[[Category: Lerner C]]
-	[[Category: Rudolph~~, M G]]~~	+	[[Category: Rudolph MG]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Neurotransmitter degradation]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:48, 12 August 2020

OCA — Wed, 12 Aug 2020 10:48:37 GMT

←Older revision		Revision as of 10:48, 12 August 2020
Line 1:		Line 1:

	==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A==		==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A==
-	<StructureSection load='5lsa' size='340' side='right' caption='[[5lsa]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5lsa' size='340' side='right'caption='[[5lsa]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LSA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LSA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [http://pdbe.org/5lsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [http://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [http://pdbe.org/5lsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [http://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Catechol O-methyltransferase]]		[[Category: Catechol O-methyltransferase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ehler, A]]		[[Category: Ehler, A]]
	[[Category: Lerner, C]]		[[Category: Lerner, C]]

OCA: Protected "5lsa" [edit=sysop:move=sysop]

OCA — Sat, 10 Sep 2016 21:16:00 GMT

Protected "5lsa" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:16, 10 September 2016

OCA: New page: ==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A==
OCA — Sat, 10 Sep 2016 21:15:57 GMT

New page: ==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A== <StructureSection load='5lsa' size='340' side='right' caption='5lsa, resolution 1.50Å'...

New page

==human catechol O-methyltransferase in complex with SAM and DNC at 1.50A==
<StructureSection load='5lsa' size='340' side='right' caption='[[5lsa]], [[Resolution|resolution]] 1.50Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5lsa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LSA FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DNC:3,5-DINITROCATECHOL'>DNC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsa OCA], [http://pdbe.org/5lsa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lsa RCSB], [http://www.ebi.ac.uk/pdbsum/5lsa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsa ProSAT]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/COMT_HUMAN COMT_HUMAN]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
TOC
</StructureSection>
[[Category: Catechol O-methyltransferase]]
[[Category: Ehler, A]]
[[Category: Lerner, C]]
[[Category: Rudolph, M G]]
[[Category: Methyltransferase]]
[[Category: Neurotransmitter degradation]]
[[Category: Transferase]]