5ltw - Revision history

OCA at 18:49, 18 October 2023

OCA — Wed, 18 Oct 2023 18:49:19 GMT

←Older revision		Revision as of 18:49, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5ltw' size='340' side='right'caption='[[5ltw]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='5ltw' size='340' side='right'caption='[[5ltw]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LTW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LTW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2~~-~~AMINO-2-HYDROXYMETHYL-PROPANE-1~~,~~3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SEP~~:~~PHOSPHOSERINE~~'>~~SEP~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HSPB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [https://pdbe.org/5ltw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [https://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [~~http~~://pdbe.org/5ltw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.	+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antson~~, A A~~]]	+	[[Category: Antson AA]]
-	[[Category: Beelen, S]]	+	[[Category: Beelen S]]
-	[[Category: Gusev~~, N B~~]]	+	[[Category: Gusev NB]]
-	[[Category: Kulikova~~, A A~~]]	+	[[Category: Kulikova AA]]
-	[[Category: Sluchanko~~, N N~~]]	+	[[Category: Sluchanko NN]]
-	[[Category: Strelkov~~, S V~~]]	+	[[Category: Strelkov SV]]
-	[[Category: Weeks~~, S D]]~~	+	[[Category: Weeks SD]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Protein-protein complex~~]]	+

OCA at 10:50, 12 August 2020

OCA — Wed, 12 Aug 2020 10:50:25 GMT

←Older revision		Revision as of 10:50, 12 August 2020
Line 1:		Line 1:

	==Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6==		==Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6==
-	<StructureSection load='5ltw' size='340' side='right' caption='[[5ltw]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<StructureSection load='5ltw' size='340' side='right'caption='[[5ltw]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LTW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LTW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [http://pdbe.org/5ltw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [http://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HSPB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [http://pdbe.org/5ltw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [http://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:

	==See Also==		==See Also==
-	*[[14-3-3 protein\|14-3-3 protein]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Beelen, S]]		[[Category: Beelen, S]]

OCA at 07:20, 9 March 2017

OCA — Thu, 09 Mar 2017 07:20:51 GMT

←Older revision		Revision as of 07:20, 9 March 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5ltw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ltw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein\|14-3-3 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:58, 1 February 2017

OCA — Wed, 01 Feb 2017 17:58:17 GMT

←Older revision		Revision as of 17:58, 1 February 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ltw is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6==
		+	<StructureSection load='5ltw' size='340' side='right' caption='[[5ltw]], [[Resolution\|resolution]] 4.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LTW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [http://pdbe.org/5ltw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [http://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	By interacting with hundreds of protein partners, 14-3-3 proteins coordinate vital cellular processes. Phosphorylation of the small heat shock protein, HSPB6, within its intrinsically disordered N-terminal domain activates its interaction with 14-3-3, ultimately triggering smooth muscle relaxation. After analyzing the binding of an HSPB6-derived phosphopeptide to 14-3-3 using isothermal calorimetry and X-ray crystallography, we have determined the crystal structure of the complete assembly consisting of the 14-3-3 dimer and full-length HSPB6 dimer and further characterized this complex in solution using fluorescence spectroscopy, small-angle X-ray scattering, and limited proteolysis. We show that selected intrinsically disordered regions of HSPB6 are transformed into well-defined conformations upon the interaction, whereby an unexpectedly asymmetric structure is formed. This structure provides the first atomic resolution snapshot of a human small HSP in functional state, explains how 14-3-3 proteins sequester their regulatory partners, and can inform the design of small-molecule interaction modifiers to be used as myorelaxants.

-	~~Authors~~:	+	Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.,Sluchanko NN, Beelen S, Kulikova AA, Weeks SD, Antson AA, Gusev NB, Strelkov SV Structure. 2016 Dec 30. pii: S0969-2126(16)30395-1. doi:, 10.1016/j.str.2016.12.005. PMID:28089448<ref>PMID:28089448</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ltw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Antson, A A]]
		+	[[Category: Beelen, S]]
		+	[[Category: Gusev, N B]]
		+	[[Category: Kulikova, A A]]
		+	[[Category: Sluchanko, N N]]
		+	[[Category: Strelkov, S V]]
		+	[[Category: Weeks, S D]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein-protein complex]]

OCA at 16:07, 9 December 2016

OCA — Fri, 09 Dec 2016 16:07:00 GMT

←Older revision		Revision as of 16:07, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ltw is ON HOLD	+	The entry 5ltw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5ltw" [edit=sysop:move=sysop]

OCA — Wed, 14 Sep 2016 13:41:22 GMT

Protected "5ltw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:41, 14 September 2016

OCA: New page: '''Unreleased structure''' The entry 5ltw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Sep 2016 13:41:21 GMT

New page: '''Unreleased structure''' The entry 5ltw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ltw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]