5lu2 - Revision history

OCA at 18:49, 18 October 2023

OCA — Wed, 18 Oct 2023 18:49:39 GMT

←Older revision		Revision as of 18:49, 18 October 2023
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	<StructureSection load='5lu2' size='340' side='right'caption='[[5lu2]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5lu2' size='340' side='right'caption='[[5lu2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lu2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lu2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LU2 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SFN, HME1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu2 OCA], [~~http~~://pdbe.org/5lu2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lu2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lu2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu2 OCA], [https://pdbe.org/5lu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lu2 RCSB], [https://www.ebi.ac.uk/pdbsum/5lu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.	+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antson~~, A A~~]]	+	[[Category: Antson AA]]
-	[[Category: Beelen, S]]	+	[[Category: Beelen S]]
-	[[Category: Gusev~~, N B~~]]	+	[[Category: Gusev NB]]
-	[[Category: Kulikova~~, A A~~]]	+	[[Category: Kulikova AA]]
-	[[Category: Sluchanko~~, N N~~]]	+	[[Category: Sluchanko NN]]
-	[[Category: Strelkov~~, S V~~]]	+	[[Category: Strelkov SV]]
-	[[Category: Weeks~~, S D]]~~	+	[[Category: Weeks SD]]
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:50, 12 August 2020

OCA — Wed, 12 Aug 2020 10:50:27 GMT

←Older revision		Revision as of 10:50, 12 August 2020
Line 1:		Line 1:

	==Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide==		==Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide==
-	<StructureSection load='5lu2' size='340' side='right' caption='[[5lu2]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5lu2' size='340' side='right'caption='[[5lu2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lu2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LU2 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu2 OCA], [http://pdbe.org/5lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu2 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu2 OCA], [http://pdbe.org/5lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[14-3-3 protein\|14-3-3 protein]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Beelen, S]]		[[Category: Beelen, S]]

OCA at 07:32, 9 March 2017

OCA — Thu, 09 Mar 2017 07:32:52 GMT

←Older revision		Revision as of 07:32, 9 March 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5lu2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lu2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein\|14-3-3 protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:51, 1 February 2017

OCA — Wed, 01 Feb 2017 17:51:12 GMT

←Older revision		Revision as of 17:51, 1 February 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lu2 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide==
		+	<StructureSection load='5lu2' size='340' side='right' caption='[[5lu2]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lu2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LU2 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lu2 OCA], [http://pdbe.org/5lu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lu2 RCSB], [http://www.ebi.ac.uk/pdbsum/5lu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lu2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	By interacting with hundreds of protein partners, 14-3-3 proteins coordinate vital cellular processes. Phosphorylation of the small heat shock protein, HSPB6, within its intrinsically disordered N-terminal domain activates its interaction with 14-3-3, ultimately triggering smooth muscle relaxation. After analyzing the binding of an HSPB6-derived phosphopeptide to 14-3-3 using isothermal calorimetry and X-ray crystallography, we have determined the crystal structure of the complete assembly consisting of the 14-3-3 dimer and full-length HSPB6 dimer and further characterized this complex in solution using fluorescence spectroscopy, small-angle X-ray scattering, and limited proteolysis. We show that selected intrinsically disordered regions of HSPB6 are transformed into well-defined conformations upon the interaction, whereby an unexpectedly asymmetric structure is formed. This structure provides the first atomic resolution snapshot of a human small HSP in functional state, explains how 14-3-3 proteins sequester their regulatory partners, and can inform the design of small-molecule interaction modifiers to be used as myorelaxants.

-	~~Authors:~~ Sluchanko~~, N.N.~~, Beelen, S., Kulikova~~, A.A.~~, Weeks~~, S.D.~~, Antson~~, A.A.~~, Gusev, N.B., ~~Strelkov, S~~.V.	+	Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.,Sluchanko NN, Beelen S, Kulikova AA, Weeks SD, Antson AA, Gusev NB, Strelkov SV Structure. 2016 Dec 30. pii: S0969-2126(16)30395-1. doi:, 10.1016/j.str.2016.12.005. PMID:28089448<ref>PMID:28089448</ref>

-	~~Description: Human sigma wild-type adaptor phosphopeptide complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Sluchanko~~, N.~~N]]~~	+	<div class="pdbe-citations 5lu2" style="background-color:#fffaf0;"></div>
-	~~[[Category: Strelkov,~~ S.~~V]]~~	+	== References ==
-	[[Category: Antson, A.A]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Antson, A A]]
	[[Category: Beelen, S]]		[[Category: Beelen, S]]
-	[[Category: Gusev, N.B]]	+	[[Category: Gusev, N B]]
-	[[Category: Kulikova, A.A]]	+	[[Category: Kulikova, A A]]
-	[[Category: Weeks, S.D]]	+	[[Category: Sluchanko, N N]]
		+	[[Category: Strelkov, S V]]
		+	[[Category: Weeks, S D]]
		+	[[Category: Protein-peptide complex]]
		+	[[Category: Signaling protein]]

OCA: Protected "5lu2" [edit=sysop:move=sysop]

OCA — Wed, 14 Sep 2016 13:42:03 GMT

Protected "5lu2" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:42, 14 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lu2 is ON HOLD until Paper Publication Authors: Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V....

OCA — Wed, 14 Sep 2016 13:42:01 GMT

New page: '''Unreleased structure''' The entry 5lu2 is ON HOLD until Paper Publication Authors: Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V....

New page

'''Unreleased structure'''

The entry 5lu2 is ON HOLD until Paper Publication

Authors: Sluchanko, N.N., Beelen, S., Kulikova, A.A., Weeks, S.D., Antson, A.A., Gusev, N.B., Strelkov, S.V.

Description: Human sigma wild-type adaptor phosphopeptide complex
[[Category: Unreleased Structures]]
[[Category: Sluchanko, N.N]]
[[Category: Strelkov, S.V]]
[[Category: Antson, A.A]]
[[Category: Beelen, S]]
[[Category: Gusev, N.B]]
[[Category: Kulikova, A.A]]
[[Category: Weeks, S.D]]