5lum - Revision history

OCA at 18:50, 18 October 2023

OCA — Wed, 18 Oct 2023 18:50:20 GMT

←Older revision		Revision as of 18:50, 18 October 2023
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	<StructureSection load='5lum' size='340' side='right'caption='[[5lum]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5lum' size='340' side='right'caption='[[5lum]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lum]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LUM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lum]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LUM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HSPB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lum OCA], [~~http~~://pdbe.org/5lum PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lum RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lum PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lum ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lum OCA], [https://pdbe.org/5lum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lum RCSB], [https://www.ebi.ac.uk/pdbsum/5lum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lum ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HSPB6_HUMAN HSPB6_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Antson~~, A A~~]]	+	[[Category: Antson AA]]
-	[[Category: Beelen, S]]	+	[[Category: Beelen S]]
-	[[Category: Gusev~~, N B~~]]	+	[[Category: Gusev NB]]
-	[[Category: Kulikova~~, A A~~]]	+	[[Category: Kulikova AA]]
-	[[Category: Sluchanko~~, N N~~]]	+	[[Category: Sluchanko NN]]
-	[[Category: Strelkov~~, S V~~]]	+	[[Category: Strelkov SV]]
-	[[Category: Weeks~~, S D]]~~	+	[[Category: Weeks SD]]
-	~~[[Category: Chaperone protein]]~~	+
-	~~[[Category: Idr]]~~	+
-	~~[[Category: Protein-peptide complex~~]]	+

OCA at 10:50, 12 August 2020

OCA — Wed, 12 Aug 2020 10:50:59 GMT

←Older revision		Revision as of 10:50, 12 August 2020
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	==Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide==		==Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide==
-	<StructureSection load='5lum' size='340' side='right' caption='[[5lum]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5lum' size='340' side='right'caption='[[5lum]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lum]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LUM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lum]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LUM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lum OCA], [http://pdbe.org/5lum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lum RCSB], [http://www.ebi.ac.uk/pdbsum/5lum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lum ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSPB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lum OCA], [http://pdbe.org/5lum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lum RCSB], [http://www.ebi.ac.uk/pdbsum/5lum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lum ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5lum" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lum" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Antson, A A]]		[[Category: Antson, A A]]
	[[Category: Beelen, S]]		[[Category: Beelen, S]]

OCA at 17:55, 1 February 2017

OCA — Wed, 01 Feb 2017 17:55:39 GMT

←Older revision		Revision as of 17:55, 1 February 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lum is ~~ON HOLD until Paper~~ Publication	+	==Alpha-crystallin domain of human HSPB6 patched with its N-terminal peptide==
		+	<StructureSection load='5lum' size='340' side='right' caption='[[5lum]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lum]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LUM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lum OCA], [http://pdbe.org/5lum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lum RCSB], [http://www.ebi.ac.uk/pdbsum/5lum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lum ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	By interacting with hundreds of protein partners, 14-3-3 proteins coordinate vital cellular processes. Phosphorylation of the small heat shock protein, HSPB6, within its intrinsically disordered N-terminal domain activates its interaction with 14-3-3, ultimately triggering smooth muscle relaxation. After analyzing the binding of an HSPB6-derived phosphopeptide to 14-3-3 using isothermal calorimetry and X-ray crystallography, we have determined the crystal structure of the complete assembly consisting of the 14-3-3 dimer and full-length HSPB6 dimer and further characterized this complex in solution using fluorescence spectroscopy, small-angle X-ray scattering, and limited proteolysis. We show that selected intrinsically disordered regions of HSPB6 are transformed into well-defined conformations upon the interaction, whereby an unexpectedly asymmetric structure is formed. This structure provides the first atomic resolution snapshot of a human small HSP in functional state, explains how 14-3-3 proteins sequester their regulatory partners, and can inform the design of small-molecule interaction modifiers to be used as myorelaxants.

-	~~Authors~~:	+	Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.,Sluchanko NN, Beelen S, Kulikova AA, Weeks SD, Antson AA, Gusev NB, Strelkov SV Structure. 2016 Dec 30. pii: S0969-2126(16)30395-1. doi:, 10.1016/j.str.2016.12.005. PMID:28089448<ref>PMID:28089448</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5lum" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Antson, A A]]
		+	[[Category: Beelen, S]]
		+	[[Category: Gusev, N B]]
		+	[[Category: Kulikova, A A]]
		+	[[Category: Sluchanko, N N]]
		+	[[Category: Strelkov, S V]]
		+	[[Category: Weeks, S D]]
		+	[[Category: Chaperone protein]]
		+	[[Category: Idr]]
		+	[[Category: Protein-peptide complex]]

OCA at 11:50, 21 September 2016

OCA — Wed, 21 Sep 2016 11:50:28 GMT

←Older revision		Revision as of 11:50, 21 September 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lum is ON HOLD	+	The entry 5lum is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5lum" [edit=sysop:move=sysop]

OCA — Wed, 14 Sep 2016 13:43:27 GMT

Protected "5lum" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:43, 14 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lum is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Sep 2016 13:43:26 GMT

New page: '''Unreleased structure''' The entry 5lum is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5lum is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]