5lv1 - Revision history

OCA at 18:50, 18 October 2023

OCA — Wed, 18 Oct 2023 18:50:46 GMT

←Older revision		Revision as of 18:50, 18 October 2023
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	==2.12 A resolution structure of PtxB from Prochlorococcus marinus (MIT 9301) in complex with phosphite==		==2.12 A resolution structure of PtxB from Prochlorococcus marinus (MIT 9301) in complex with phosphite==
-	<StructureSection load='5lv1' size='340' side='right' caption='[[5lv1]], [[Resolution\|resolution]] 2.12Å' scene=''>	+	<StructureSection load='5lv1' size='340' side='right'caption='[[5lv1]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lv1]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Prom0 Prom0~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LV1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lv1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochlorococcus_marinus_str._MIT_9301 Prochlorococcus marinus str. MIT 9301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LV1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=78T:oxidanylphosphinate'>78T</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.12Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jvb\|5jvb]]~~, [[~~5lq5~~\|~~5lq5~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=78T:oxidanylphosphinate'>78T</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~P9301_12511 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=167546 PROM0])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv1 OCA], [https://pdbe.org/5lv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lv1 RCSB], [https://www.ebi.ac.uk/pdbsum/5lv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv1 OCA], [~~http~~://pdbe.org/5lv1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lv1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lv1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PHND2_PROM0 PHND2_PROM0]] Probably part of the ABC transporter complex PhnC2D2E2. Binds strongly to methylphosphonate (MPn), ethylphosphonate (EPn) and inorganic phosphite.<ref>PMID:22011717</ref>	+	[https://www.uniprot.org/uniprot/PHND2_PROM0 PHND2_PROM0] Probably part of the ABC transporter complex PhnC2D2E2. Binds strongly to methylphosphonate (MPn), ethylphosphonate (EPn) and inorganic phosphite.<ref>PMID:22011717</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Prom0~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Adams, N B~~.P]]	+	[[Category: Prochlorococcus marinus str. MIT 9301]]
-	[[Category: Bibby~~, T S~~]]	+	[[Category: Adams NBP]]
-	[[Category: Bisson, C]]	+	[[Category: Bibby TS]]
-	[[Category: Hitchcock, A]]	+	[[Category: Bisson C]]
-	[[Category: Hunter~~, C N~~]]	+	[[Category: Hitchcock A]]
-	[[Category: Polyviou, D]]	+	[[Category: Hunter CN]]
-	~~[[Category: Abc-transporter]]~~	+	[[Category: Polyviou D]]
-	~~[[Category: Periplasmic binding protein]]~~	+
-	~~[[Category: Phosphite]]~~	+
-	~~[[Category: Prochlorococcus~~]]	+

OCA at 20:39, 24 January 2018

OCA — Wed, 24 Jan 2018 20:39:34 GMT

←Older revision		Revision as of 20:39, 24 January 2018
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	<StructureSection load='5lv1' size='340' side='right' caption='[[5lv1]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='5lv1' size='340' side='right' caption='[[5lv1]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lv1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LV1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lv1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Prom0 Prom0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LV1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78T:oxidanylphosphinate'>78T</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78T:oxidanylphosphinate'>78T</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jvb\|5jvb]], [[5lq5\|5lq5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jvb\|5jvb]], [[5lq5\|5lq5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">P9301_12511 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=167546 PROM0])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv1 OCA], [http://pdbe.org/5lv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv1 OCA], [http://pdbe.org/5lv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv1 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Prom0]]
	[[Category: Adams, N B.P]]		[[Category: Adams, N B.P]]
	[[Category: Bibby, T S]]		[[Category: Bibby, T S]]

OCA at 07:09, 6 December 2017

OCA — Wed, 06 Dec 2017 07:09:07 GMT

←Older revision		Revision as of 07:09, 6 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lv1 is ~~ON HOLD~~	+	==2.12 A resolution structure of PtxB from Prochlorococcus marinus (MIT 9301) in complex with phosphite==
		+	<StructureSection load='5lv1' size='340' side='right' caption='[[5lv1]], [[Resolution\|resolution]] 2.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lv1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LV1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78T:oxidanylphosphinate'>78T</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jvb\|5jvb]], [[5lq5\|5lq5]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lv1 OCA], [http://pdbe.org/5lv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lv1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHND2_PROM0 PHND2_PROM0]] Probably part of the ABC transporter complex PhnC2D2E2. Binds strongly to methylphosphonate (MPn), ethylphosphonate (EPn) and inorganic phosphite.<ref>PMID:22011717</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inorganic phosphate is the major bioavailable form of the essential nutrient phosphorus. However, the concentration of phosphate in most natural habitats is low enough to limit microbial growth. Under phosphate-depleted conditions some bacteria utilise phosphite and hypophosphite as alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition from the environment is not fully understood. Here, we present crystal structures and ligand binding affinities of periplasmic binding proteins from bacterial phosphite and hypophosphite ATP-binding cassette transporters. We reveal that phosphite and hypophosphite specificity results from a combination of steric selection and the presence of a P-H...pi interaction between the ligand and a conserved aromatic residue in the ligand-binding pocket. The characterisation of high affinity and specific transporters has implications for the marine phosphorus redox cycle, and might aid the use of phosphite as an alternative phosphorus source in biotechnological, industrial and agricultural applications.

-	~~Authors: Bisson~~, C., Adams, N.B~~.P.~~, Polyviou, D., Bibby, ~~T.S.~~, Hunter~~, C.N.~~, Hitchcock, A.	+	The molecular basis of phosphite and hypophosphite recognition by ABC-transporters.,Bisson C, Adams NBP, Stevenson B, Brindley AA, Polyviou D, Bibby TS, Baker PJ, Hunter CN, Hitchcock A Nat Commun. 2017 Nov 23;8(1):1746. doi: 10.1038/s41467-017-01226-8. PMID:29170493<ref>PMID:29170493</ref>

-	~~Description: 2~~.~~12 A resolution structure~~ of ~~PtxB from Prochlorococcus marinus (MIT 9301) in complex with phosphite~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Polyviou~~, D]]	+	<div class="pdbe-citations 5lv1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adams, N B.P]]
		+	[[Category: Bibby, T S]]
	[[Category: Bisson, C]]		[[Category: Bisson, C]]
-	[[Category: Adams, N.B.P]]
	[[Category: Hitchcock, A]]		[[Category: Hitchcock, A]]
-	[[Category: ~~Bibby~~, ~~T.S~~]]	+	[[Category: Hunter, C N]]
-	[[Category: ~~Hunter~~, ~~C.N~~]]	+	[[Category: Polyviou, D]]
		+	[[Category: Abc-transporter]]
		+	[[Category: Periplasmic binding protein]]
		+	[[Category: Phosphite]]
		+	[[Category: Prochlorococcus]]

OCA at 10:53, 9 March 2017

OCA — Thu, 09 Mar 2017 10:53:41 GMT

←Older revision		Revision as of 10:53, 9 March 2017
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	[[Category: Polyviou, D]]		[[Category: Polyviou, D]]
	[[Category: Bisson, C]]		[[Category: Bisson, C]]
		+	[[Category: Adams, N.B.P]]
	[[Category: Hitchcock, A]]		[[Category: Hitchcock, A]]
	[[Category: Bibby, T.S]]		[[Category: Bibby, T.S]]
	[[Category: Hunter, C.N]]		[[Category: Hunter, C.N]]
-	[[Category: Adams, N.B.P]]

OCA: Protected "5lv1" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2016 11:51:39 GMT

Protected "5lv1" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 21 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lv1 is ON HOLD Authors: Bisson, C., Adams, N.B.P., Polyviou, D., Bibby, T.S., Hunter, C.N., Hitchcock, A. Description: 2.12 A resolution structure...

OCA — Wed, 21 Sep 2016 11:51:37 GMT

New page: '''Unreleased structure''' The entry 5lv1 is ON HOLD Authors: Bisson, C., Adams, N.B.P., Polyviou, D., Bibby, T.S., Hunter, C.N., Hitchcock, A. Description: 2.12 A resolution structure...

New page

'''Unreleased structure'''

The entry 5lv1 is ON HOLD

Authors: Bisson, C., Adams, N.B.P., Polyviou, D., Bibby, T.S., Hunter, C.N., Hitchcock, A.

Description: 2.12 A resolution structure of PtxB from Prochlorococcus marinus (MIT 9301) in complex with phosphite
[[Category: Unreleased Structures]]
[[Category: Polyviou, D]]
[[Category: Bisson, C]]
[[Category: Hitchcock, A]]
[[Category: Bibby, T.S]]
[[Category: Hunter, C.N]]
[[Category: Adams, N.B.P]]