5lxy - Revision history

OCA at 10:56, 25 October 2023

OCA — Wed, 25 Oct 2023 10:56:14 GMT

←Older revision		Revision as of 10:56, 25 October 2023
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	<StructureSection load='5lxy' size='340' side='right'caption='[[5lxy]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='5lxy' size='340' side='right'caption='[[5lxy]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lxy]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lxy]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LXY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RBM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), ZCCHC8 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxy OCA], [~~http~~://pdbe.org/5lxy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lxy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lxy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxy OCA], [https://pdbe.org/5lxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lxy RCSB], [https://www.ebi.ac.uk/pdbsum/5lxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RBM7_HUMAN RBM7_HUMAN]] Possible involved in germ cell RNA processing and meiosis~~. [[http://www.uniprot.org/uniprot/ZCHC8_HUMAN ZCHC8_HUMAN]] May be involved in pre-mRNA splicing~~.	+	[https://www.uniprot.org/uniprot/RBM7_HUMAN RBM7_HUMAN] Possible involved in germ cell RNA processing and meiosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benda, C]]	+	[[Category: Benda C]]
-	[[Category: Conti, E]]	+	[[Category: Conti E]]
-	[[Category: Falk, S]]	+	[[Category: Falk S]]
-	[[Category: Finogenova, K]]	+	[[Category: Finogenova K]]
-	~~[[Category: Next complex rrm rbm7 zcchc8]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 10:54, 12 August 2020

OCA — Wed, 12 Aug 2020 10:54:19 GMT

←Older revision		Revision as of 10:54, 12 August 2020
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	==Structure of the minimal RBM7 - ZCCHC8 Complex==		==Structure of the minimal RBM7 - ZCCHC8 Complex==
-	<StructureSection load='5lxy' size='340' side='right' caption='[[5lxy]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='5lxy' size='340' side='right'caption='[[5lxy]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lxy]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lxy]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LXY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxy OCA], [http://pdbe.org/5lxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxy RCSB], [http://www.ebi.ac.uk/pdbsum/5lxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxy ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ZCCHC8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxy OCA], [http://pdbe.org/5lxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxy RCSB], [http://www.ebi.ac.uk/pdbsum/5lxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Benda, C]]		[[Category: Benda, C]]
	[[Category: Conti, E]]		[[Category: Conti, E]]

OCA at 18:58, 15 December 2016

OCA — Thu, 15 Dec 2016 18:58:22 GMT

←Older revision		Revision as of 18:58, 15 December 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5lxy is ~~ON HOLD until Paper~~ Publication	+	==Structure of the minimal RBM7 - ZCCHC8 Complex==
		+	<StructureSection load='5lxy' size='340' side='right' caption='[[5lxy]], [[Resolution\|resolution]] 2.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lxy]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LXY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lxy OCA], [http://pdbe.org/5lxy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lxy RCSB], [http://www.ebi.ac.uk/pdbsum/5lxy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lxy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RBM7_HUMAN RBM7_HUMAN]] Possible involved in germ cell RNA processing and meiosis. [[http://www.uniprot.org/uniprot/ZCHC8_HUMAN ZCHC8_HUMAN]] May be involved in pre-mRNA splicing.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors (RBM7, ZCCHC8 and hMTR4) interact to form the nuclear exosome targeting (NEXT) complex, which directs a subset of non-coding RNAs for exosomal degradation. Here we elucidate how RBM7 is incorporated in the NEXT complex. We identify a proline-rich segment of ZCCHC8 as the interaction site for the RNA-recognition motif (RRM) of RBM7 and present the crystal structure of the corresponding complex at 2.0 A resolution. On the basis of the structure, we identify a proline-rich segment within the splicing factor SAP145 with strong similarity to ZCCHC8. We show that this segment of SAP145 not only binds the RRM region of another splicing factor SAP49 but also the RRM of RBM7. These dual interactions of RBM7 with the exosome and the spliceosome suggest a model whereby NEXT might recruit the exosome to degrade intronic RNAs.

-	~~Authors: Falk~~, S., Finogenova, K., ~~Benda~~, C., ~~Conti~~, E.	+	Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.,Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E Nat Commun. 2016 Dec 1;7:13573. doi: 10.1038/ncomms13573. PMID:27905398<ref>PMID:27905398</ref>

-	~~Description: Structure~~ of the ~~minimal RBM7 -ZCCHC8 Complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Finogenova, K]]~~	+	<div class="pdbe-citations 5lxy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Benda, C]]		[[Category: Benda, C]]
-	[[Category: Falk, S]]
	[[Category: Conti, E]]		[[Category: Conti, E]]
		+	[[Category: Falk, S]]
		+	[[Category: Finogenova, K]]
		+	[[Category: Next complex rrm rbm7 zcchc8]]
		+	[[Category: Rna binding protein]]

OCA at 14:55, 19 October 2016

OCA — Wed, 19 Oct 2016 14:55:13 GMT

←Older revision		Revision as of 14:55, 19 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lxy is ON HOLD	+	The entry 5lxy is ON HOLD until Paper Publication

	Authors: Falk, S., Finogenova, K., Benda, C., Conti, E.		Authors: Falk, S., Finogenova, K., Benda, C., Conti, E.

OCA: Protected "5lxy" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2016 19:20:13 GMT

Protected "5lxy" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:20, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5lxy is ON HOLD Authors: Falk, S., Finogenova, K., Benda, C., Conti, E. Description: Structure of the minimal RBM7 -ZCCHC8 Complex [[Category: Unre...

OCA — Wed, 05 Oct 2016 19:20:12 GMT

New page: '''Unreleased structure''' The entry 5lxy is ON HOLD Authors: Falk, S., Finogenova, K., Benda, C., Conti, E. Description: Structure of the minimal RBM7 -ZCCHC8 Complex [[Category: Unre...

New page

'''Unreleased structure'''

The entry 5lxy is ON HOLD

Authors: Falk, S., Finogenova, K., Benda, C., Conti, E.

Description: Structure of the minimal RBM7 -ZCCHC8 Complex
[[Category: Unreleased Structures]]
[[Category: Finogenova, K]]
[[Category: Benda, C]]
[[Category: Falk, S]]
[[Category: Conti, E]]