5lyn - Revision history

OCA at 10:56, 25 October 2023

OCA — Wed, 25 Oct 2023 10:56:48 GMT

←Older revision		Revision as of 10:56, 25 October 2023
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	==Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment==		==Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment==
-	<StructureSection load='5lyn' size='340' side='right' caption='[[5lyn]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5lyn' size='340' side='right'caption='[[5lyn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lyn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lyn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LYN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SGT2, YOR007C, UNF346 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyn OCA], [~~http~~://pdbe.org/5lyn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lyn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lyn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyn OCA], [https://pdbe.org/5lyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lyn RCSB], [https://www.ebi.ac.uk/pdbsum/5lyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>	+	[https://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5lyn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lyn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Small glutamine-rich tetratricopeptide repeat containing protein alpha\|Small glutamine-rich tetratricopeptide repeat containing protein alpha]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 18824~~]]	+	[[Category: Large Structures]]
-	[[Category: Evans~~, N J~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: Isaacson~~, R L~~]]	+	[[Category: Evans NJ]]
-	[[Category: Krysztofinska~~, E M~~]]	+	[[Category: Isaacson RL]]
-	[[Category: Martinez-Lumbreras, S]]	+	[[Category: Krysztofinska EM]]
-	[[Category: Morgan~~, R M.L~~]]	+	[[Category: Martinez-Lumbreras S]]
-	[[Category: Murray~~, J W~~]]	+	[[Category: Morgan RML]]
-	[[Category: Thapaliya, A]]	+	[[Category: Murray JW]]
-	~~[[Category: Chaperone~~]]	+	[[Category: Thapaliya A]]

OCA at 07:44, 8 November 2017

OCA — Wed, 08 Nov 2017 07:44:49 GMT

←Older revision		Revision as of 07:44, 8 November 2017
Line 3:		Line 3:
	<StructureSection load='5lyn' size='340' side='right' caption='[[5lyn]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5lyn' size='340' side='right' caption='[[5lyn]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lyn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lyn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SGT2, YOR007C, UNF346 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyn OCA], [http://pdbe.org/5lyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyn RCSB], [http://www.ebi.ac.uk/pdbsum/5lyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyn OCA], [http://pdbe.org/5lyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyn RCSB], [http://www.ebi.ac.uk/pdbsum/5lyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>		[[http://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small glutamine-rich tetratricopeptide repeat-containing protein 2 (Sgt2) is a multi-module co-chaperone involved in several protein quality control pathways. The TPR domain of Sgt2 and several other proteins, including SGTA, Hop, and CHIP, is a highly conserved motif known to form transient complexes with molecular chaperones such as Hsp70 and Hsp90. In this work, we present the first high resolution crystal structures of Sgt2_TPR alone and in complex with a C-terminal peptide PTVEEVD from heat shock protein, Ssa1. Using nuclear magnetic resonance spectroscopy and isothermal titration calorimetry, we demonstrate that Sgt2_TPR interacts with peptides corresponding to the C-termini of Ssa1, Hsc82, and Ybr137wp with similar binding modes and affinities.
		+
		+	Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.,Krysztofinska EM, Evans NJ, Thapaliya A, Murray JW, Morgan RML, Martinez-Lumbreras S, Isaacson RL Front Mol Biosci. 2017 Oct 11;4:68. doi: 10.3389/fmolb.2017.00068. eCollection, 2017. PMID:29075633<ref>PMID:29075633</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5lyn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 18824]]
	[[Category: Evans, N J]]		[[Category: Evans, N J]]
	[[Category: Isaacson, R L]]		[[Category: Isaacson, R L]]

OCA at 07:11, 25 October 2017

OCA — Wed, 25 Oct 2017 07:11:54 GMT

←Older revision		Revision as of 07:11, 25 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5lyn is ~~ON HOLD until Paper Publication~~	+	==Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment==
-		+	<StructureSection load='5lyn' size='340' side='right' caption='[[5lyn]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~: ~~Krysztofinska~~, E.M., ~~Evans~~, N.J., ~~Thapaliya, A~~., ~~Murray, J~~.W., ~~Morgan~~, R~~.M.~~L., Martinez-Lumbreras, S~~., Isaacson~~, R.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lyn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYN FirstGlance]. <br>
-	~~Description: Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyn OCA], [http://pdbe.org/5lyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyn RCSB], [http://www.ebi.ac.uk/pdbsum/5lyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyn ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SGT2_YEAST SGT2_YEAST]] Co-chaperone that binds to the molecular chaperone Hsp70 (SSA1 and SSA2). Regulates Hsp70 ATPase activity (By similarity). Required for recovery from heat shock.<ref>PMID:12482202</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Evans, N J]]
		+	[[Category: Isaacson, R L]]
		+	[[Category: Krysztofinska, E M]]
		+	[[Category: Martinez-Lumbreras, S]]
		+	[[Category: Morgan, R M.L]]
		+	[[Category: Murray, J W]]
	[[Category: Thapaliya, A]]		[[Category: Thapaliya, A]]
-	[[Category: ~~Isaacson, R.L]]~~	+	[[Category: Chaperone]]
-	~~[[Category: Krysztofinska, E.M]]~~	+
-	~~[[Category: Evans, N.J]]~~	+
-	~~[[Category: Murray, J.W]]~~	+
-	~~[[Category: Morgan, R.M.L]]~~	+
-	~~[[Category: Martinez-Lumbreras, S~~]]	+

OCA at 10:57, 9 March 2017

OCA — Thu, 09 Mar 2017 10:57:32 GMT

←Older revision		Revision as of 10:57, 9 March 2017
Line 7:		Line 7:
	Description: Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment		Description: Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Krysztofinska, E.M]]
-	[[Category: Morgan, R.M.L]]
	[[Category: Thapaliya, A]]		[[Category: Thapaliya, A]]
	[[Category: Isaacson, R.L]]		[[Category: Isaacson, R.L]]
		+	[[Category: Krysztofinska, E.M]]
	[[Category: Evans, N.J]]		[[Category: Evans, N.J]]
	[[Category: Murray, J.W]]		[[Category: Murray, J.W]]
		+	[[Category: Morgan, R.M.L]]
	[[Category: Martinez-Lumbreras, S]]		[[Category: Martinez-Lumbreras, S]]

OCA at 14:56, 19 October 2016

OCA — Wed, 19 Oct 2016 14:56:41 GMT

←Older revision		Revision as of 14:56, 19 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5lyn is ON HOLD	+	The entry 5lyn is ON HOLD until Paper Publication

	Authors: Krysztofinska, E.M., Evans, N.J., Thapaliya, A., Murray, J.W., Morgan, R.M.L., Martinez-Lumbreras, S., Isaacson, R.L.		Authors: Krysztofinska, E.M., Evans, N.J., Thapaliya, A., Murray, J.W., Morgan, R.M.L., Martinez-Lumbreras, S., Isaacson, R.L.

-	Description: Structure of the Tpr Domain of Sgt2 in ~~the~~ complex with yeast ~~Sis1~~ peptide fragment.	+	Description: Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Krysztofinska, E.M]]		[[Category: Krysztofinska, E.M]]

OCA: Protected "5lyn" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2016 19:22:19 GMT

Protected "5lyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:22, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5lyn is ON HOLD Authors: Krysztofinska, E.M., Evans, N.J., Thapaliya, A., Murray, J.W., Morgan, R.M.L., Martinez-Lumbreras, S., Isaacson, R.L. Desc...

OCA — Wed, 05 Oct 2016 19:22:17 GMT

New page: '''Unreleased structure''' The entry 5lyn is ON HOLD Authors: Krysztofinska, E.M., Evans, N.J., Thapaliya, A., Murray, J.W., Morgan, R.M.L., Martinez-Lumbreras, S., Isaacson, R.L. Desc...

New page

'''Unreleased structure'''

The entry 5lyn is ON HOLD

Authors: Krysztofinska, E.M., Evans, N.J., Thapaliya, A., Murray, J.W., Morgan, R.M.L., Martinez-Lumbreras, S., Isaacson, R.L.

Description: Structure of the Tpr Domain of Sgt2 in the complex with yeast Sis1 peptide fragment.
[[Category: Unreleased Structures]]
[[Category: Krysztofinska, E.M]]
[[Category: Morgan, R.M.L]]
[[Category: Thapaliya, A]]
[[Category: Isaacson, R.L]]
[[Category: Evans, N.J]]
[[Category: Murray, J.W]]
[[Category: Martinez-Lumbreras, S]]