5lzw - Revision history

OCA at 18:18, 1 November 2023

OCA — Wed, 01 Nov 2023 18:18:47 GMT

←Older revision		Revision as of 18:18, 1 November 2023
Line 3:		Line 3:
	<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>		<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [~~http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.53Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [~~http~~://pdbe.org/5lzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [https://pdbe.org/5lzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [https://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]	+	[https://www.uniprot.org/uniprot/G1TT27_RABIT G1TT27_RABIT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Receptor~~ for activated protein kinase C 1\|~~Receptor~~ for activated protein kinase C 1]]	+	*[[3D sructureseceptor for activated protein kinase C 1\|3D sructureseceptor for activated protein kinase C 1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Brown, A]]	+	[[Category: Brown A]]
-	[[Category: Hegde~~, R S~~]]	+	[[Category: Hegde RS]]
-	[[Category: Murray, J]]	+	[[Category: Murray J]]
-	[[Category: Ramakrishnan, V]]	+	[[Category: Ramakrishnan V]]
-	[[Category: Shao, S]]	+	[[Category: Shao S]]
-	[[Category: Taunton, J]]	+	[[Category: Taunton J]]
-	~~[[Category: Elongation]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 20:50, 10 April 2020

OCA — Fri, 10 Apr 2020 20:50:04 GMT

←Older revision		Revision as of 20:50, 10 April 2020
Line 3:		Line 3:
	<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>		<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:01, 6 March 2020

OCA — Fri, 06 Mar 2020 19:01:51 GMT

←Older revision		Revision as of 19:01, 6 March 2020
Line 1:		Line 1:

	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==		==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==
-	<~~StructureSection~~ load='5lzw' size='340' side='right'caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>	+	<SX load='5lzw' size='340' side='right' viewer='molstar' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: European rabbit]]		[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:38, 11 December 2019

OCA — Wed, 11 Dec 2019 16:38:04 GMT

←Older revision		Revision as of 16:38, 11 December 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==		==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==
-	<StructureSection load='5lzw' size='340' side='right' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>	+	<StructureSection load='5lzw' size='340' side='right'caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]		[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: European rabbit]]		[[Category: European rabbit]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Brown, A]]		[[Category: Brown, A]]

OCA at 08:26, 3 October 2018

OCA — Wed, 03 Oct 2018 08:26:16 GMT

←Older revision		Revision as of 08:26, 3 October 2018
Line 3:		Line 3:
	<StructureSection load='5lzw' size='340' side='right' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>		<StructureSection load='5lzw' size='340' side='right' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5lzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lzw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Receptor for activated protein kinase C 1\|Receptor for activated protein kinase C 1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: European rabbit]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Brown, A]]		[[Category: Brown, A]]

OCA at 18:40, 10 December 2016

OCA — Sat, 10 Dec 2016 18:40:03 GMT

←Older revision		Revision as of 18:40, 10 December 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.==
		+	<StructureSection load='5lzw' size='340' side='right' caption='[[5lzw]], [[Resolution\|resolution]] 3.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lzw]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzw OCA], [http://pdbe.org/5lzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzw RCSB], [http://www.ebi.ac.uk/pdbsum/5lzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzw ProSAT]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factorGTPase complexes representing intermediates of translation elongation (aminoacyl-tRNAeEF1A), termination (eRF1eRF3), and ribosome rescue (PelotaHbs1l). Comparative analyses reveal that each decoding factor exploits the plasticity of the ribosomal decoding center to differentially remodel ribosomal proteins and rRNA. This leads to varying degrees of large-scale ribosome movements and implies distinct mechanisms for communicating information from the decoding center to each GTPase. Additional structural snapshots of the translation termination pathway reveal the conformational changes that choreograph the accommodation of decoding factors into the peptidyl transferase center. Our results provide a structural framework for how different states of the mammalian ribosome are selectively recognized by the appropriate decoding factorGTPase complex to ensure translational fidelity.

-	~~The entry 5lzw is ON HOLD~~	+	Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.,Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS Cell. 2016 Nov 17;167(5):1229-1240.e15. doi: 10.1016/j.cell.2016.10.046. PMID:27863242<ref>PMID:27863242</ref>

-	~~Authors: Shao~~, S.~~, Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.~~	+	<div class="pdbe-citations 5lzw" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Taunton~~, J]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Brown, A]]
		+	[[Category: Hegde, R S]]
	[[Category: Murray, J]]		[[Category: Murray, J]]
-	[[Category: ~~Hegde~~, ~~R.S]]~~	+	[[Category: Ramakrishnan, V]]
-	~~[[Category: Brown, A~~]]	+
	[[Category: Shao, S]]		[[Category: Shao, S]]
-	[[Category: ~~Ramakrishnan~~, V]]	+	[[Category: Taunton, J]]
		+	[[Category: Elongation]]
		+	[[Category: Ribosome]]
		+	[[Category: Translation]]

OCA: Protected "5lzw" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 14:59:09 GMT

Protected "5lzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5lzw is ON HOLD Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S. Description: Structure of the mammalian rescue...

OCA — Wed, 19 Oct 2016 14:59:08 GMT

New page: '''Unreleased structure''' The entry 5lzw is ON HOLD Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S. Description: Structure of the mammalian rescue...

New page

'''Unreleased structure'''

The entry 5lzw is ON HOLD

Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.

Description: Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.
[[Category: Unreleased Structures]]
[[Category: Taunton, J]]
[[Category: Murray, J]]
[[Category: Hegde, R.S]]
[[Category: Brown, A]]
[[Category: Shao, S]]
[[Category: Ramakrishnan, V]]