5m4y - Revision history

OCA at 18:26, 1 November 2023

OCA — Wed, 01 Nov 2023 18:26:08 GMT

←Older revision		Revision as of 18:26, 1 November 2023
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	<StructureSection load='5m4y' size='340' side='right'caption='[[5m4y]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5m4y' size='340' side='right'caption='[[5m4y]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m4y]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M4Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m4y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M4Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SSO2, YMR183C, YM8010.13C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=559292 Baker~~'~~s yeast]), SEC3, PSL1, YER008C ([http:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4y OCA], [~~http~~://pdbe.org/5m4y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m4y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m4y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4y OCA], [https://pdbe.org/5m4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m4y RCSB], [https://www.ebi.ac.uk/pdbsum/5m4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SSO2_YEAST SSO2_YEAST]] Required for vesicle fusion with ~~the plasma membrane. [[http://www.uniprot.org/uniprot/SEC3_YEAST SEC3_YEAST]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on~~ the plasma membrane.	+	[https://www.uniprot.org/uniprot/SSO2_YEAST SSO2_YEAST] Required for vesicle fusion with the plasma membrane.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Dong, G~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Zhang, Y B~~]]	+	[[Category: Dong G]]
-	[[Category: ~~Exocyst]]~~	+	[[Category: Zhang YB]]
-	~~[[Category: Sec3]]~~	+
-	~~[[Category: Sso2]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 06:33, 16 October 2019

OCA — Wed, 16 Oct 2019 06:33:51 GMT

←Older revision		Revision as of 06:33, 16 October 2019
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	==Crystal structure of the Sec3/Sso2 complex at 2.20 angstrom resolution==		==Crystal structure of the Sec3/Sso2 complex at 2.20 angstrom resolution==
-	<StructureSection load='5m4y' size='340' side='right' caption='[[5m4y]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5m4y' size='340' side='right'caption='[[5m4y]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m4y]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M4Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m4y]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M4Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO2, YMR183C, YM8010.13C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SEC3, PSL1, YER008C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4y OCA], [http://pdbe.org/5m4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4y RCSB], [http://www.ebi.ac.uk/pdbsum/5m4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4y OCA], [http://pdbe.org/5m4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4y RCSB], [http://www.ebi.ac.uk/pdbsum/5m4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4y ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Dong, G]]		[[Category: Dong, G]]
	[[Category: Zhang, Y B]]		[[Category: Zhang, Y B]]

OCA at 09:27, 10 March 2017

OCA — Fri, 10 Mar 2017 09:27:19 GMT

←Older revision		Revision as of 09:27, 10 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5m4y is ~~ON HOLD~~	+	==Crystal structure of the Sec3/Sso2 complex at 2.20 angstrom resolution==
		+	<StructureSection load='5m4y' size='340' side='right' caption='[[5m4y]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5m4y]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M4Y FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4y OCA], [http://pdbe.org/5m4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4y RCSB], [http://www.ebi.ac.uk/pdbsum/5m4y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4y ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SSO2_YEAST SSO2_YEAST]] Required for vesicle fusion with the plasma membrane. [[http://www.uniprot.org/uniprot/SEC3_YEAST SEC3_YEAST]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The soluble N-ethylmaleimide-sensitive factor-attachment protein receptors (SNAREs) constitute the core machinery for membrane fusion during eukaryotic cell vesicular trafficking. However, how the assembly of the SNARE complex is initiated is unknown. Here we report that Sec3, a component of the exocyst complex that mediates vesicle tethering during exocytosis, directly interacts with the t-SNARE protein Sso2. This interaction promotes the formation of an Sso2-Sec9 'binary' t-SNARE complex, the early rate-limiting step in SNARE complex assembly, and stimulates membrane fusion. The crystal structure of the Sec3-Sso2 complex suggests that Sec3 binding induces conformational changes of Sso2 that are crucial for the relief of its auto-inhibition. Interestingly, specific disruption of the Sec3-Sso2 interaction in cells blocks exocytosis without affecting the function of Sec3 in vesicle tethering. Our study reveals an activation mechanism for SNARE complex assembly, and uncovers a role of the exocyst in promoting membrane fusion in addition to vesicle tethering.

-	~~Authors~~:	+	Sec3 promotes the initial binary t-SNARE complex assembly and membrane fusion.,Yue P, Zhang Y, Mei K, Wang S, Lesigang J, Zhu Y, Dong G, Guo W Nat Commun. 2017 Jan 23;8:14236. doi: 10.1038/ncomms14236. PMID:28112172<ref>PMID:28112172</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5m4y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dong, G]]
		+	[[Category: Zhang, Y B]]
		+	[[Category: Exocyst]]
		+	[[Category: Sec3]]
		+	[[Category: Sso2]]
		+	[[Category: Structural protein]]

OCA: Protected "5m4y" [edit=sysop:move=sysop]

OCA — Wed, 26 Oct 2016 16:25:20 GMT

Protected "5m4y" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:25, 26 October 2016

OCA: New page: '''Unreleased structure''' The entry 5m4y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Oct 2016 16:25:19 GMT

New page: '''Unreleased structure''' The entry 5m4y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5m4y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]