5m5v - Revision history

OCA at 18:27, 1 November 2023

OCA — Wed, 01 Nov 2023 18:27:02 GMT

←Older revision		Revision as of 18:27, 1 November 2023
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	<StructureSection load='5m5v' size='340' side='right'caption='[[5m5v]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='5m5v' size='340' side='right'caption='[[5m5v]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m5v]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5M5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m5v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M5V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CLTC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9913 BOVIN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5v OCA], [~~http~~://pdbe.org/5m5v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m5v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m5v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5v OCA], [https://pdbe.org/5m5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m5v RCSB], [https://www.ebi.ac.uk/pdbsum/5m5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.	+	[https://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin]]~~	+	[[Category: Bos taurus]]
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Graham, S C]]~~	+
-	~~[[Category: Muenzner, J]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Hdag-l~~]]	+
	[[Category: Hepatitis delta virus]]		[[Category: Hepatitis delta virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Graham SC]]
		+	[[Category: Muenzner J]]

OCA at 11:02, 12 August 2020

OCA — Wed, 12 Aug 2020 11:02:21 GMT

←Older revision		Revision as of 11:02, 12 August 2020
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	==Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D virus large antigen (clade 2)==		==Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D virus large antigen (clade 2)==
-	<StructureSection load='5m5v' size='340' side='right' caption='[[5m5v]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='5m5v' size='340' side='right'caption='[[5m5v]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m5v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M5V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M5V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5v OCA], [http://pdbe.org/5m5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5v RCSB], [http://www.ebi.ac.uk/pdbsum/5m5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5v ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CLTC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5v OCA], [http://pdbe.org/5m5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5v RCSB], [http://www.ebi.ac.uk/pdbsum/5m5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5m5v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5m5v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Clathrin 3D structures\|Clathrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]
	[[Category: Muenzner, J]]		[[Category: Muenzner, J]]

OCA at 10:57, 10 December 2016

OCA — Sat, 10 Dec 2016 10:57:22 GMT

←Older revision		Revision as of 10:57, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5m5v is ~~ON HOLD~~	+	==Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D virus large antigen (clade 2)==
		+	<StructureSection load='5m5v' size='340' side='right' caption='[[5m5v]], [[Resolution\|resolution]] 1.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5m5v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M5V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5v OCA], [http://pdbe.org/5m5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5v RCSB], [http://www.ebi.ac.uk/pdbsum/5m5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Short peptide motifs in unstructured regions of clathrin-adaptor proteins recruit clathrin to membranes to facilitate post-Golgi membrane transport. Three consensus clathrin-binding peptide sequences have been identified and structural studies show that each binds distinct sites on the clathrin heavy chain N-terminal domain (NTD). A fourth binding site for adaptors on NTD has been functionally identified but not structurally characterised. We have solved high resolution structures of NTD bound to peptide motifs from the cellular clathrin adaptors beta2 adaptin and amphiphysin plus a putative viral clathrin adaptor, hepatitis D virus large antigen (HDAg-L). Surprisingly, with each peptide we observe simultaneous peptide binding at multiple sites on NTD and viral peptides binding to the same sites as cellular peptides. Peptides containing clathrin-box motifs (CBMs) with consensus sequence LPhixPhi[DE] bind at the 'arrestin box' on NTD, between beta-propeller blades 4 and 5, which had previously been thought to bind a distinct consensus sequence. Further, we structurally define the fourth peptide binding site on NTD, which we term the Royle box. In vitro binding assays show that clathrin is more readily captured by cellular CBMs than by HDAg-L, and site-directed mutagenesis confirms that multiple binding sites on NTD contribute to efficient capture by CBM peptides.

-	~~Authors: Muenzner~~, J., ~~Graham~~, S.C.	+	Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin.,Muenzner J, Traub LM, Kelly BT, Graham SC Traffic. 2016 Nov 3. doi: 10.1111/tra.12457. PMID:27813245<ref>PMID:27813245</ref>

-	~~Description: Clathrin heavy chain N-terminal domain bound to~~ a ~~clathrin-box motif from hepatitis D virus large antigen (clade 2)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Graham, S.C]]	+	<div class="pdbe-citations 5m5v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Graham, S C]]
	[[Category: Muenzner, J]]		[[Category: Muenzner, J]]
		+	[[Category: Endocytosis]]
		+	[[Category: Hdag-l]]
		+	[[Category: Hepatitis delta virus]]

OCA: Protected "5m5v" [edit=sysop:move=sysop]

OCA — Wed, 02 Nov 2016 16:01:56 GMT

Protected "5m5v" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:01, 2 November 2016

OCA: New page: '''Unreleased structure''' The entry 5m5v is ON HOLD Authors: Muenzner, J., Graham, S.C. Description: Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatiti...

OCA — Wed, 02 Nov 2016 16:01:55 GMT

New page: '''Unreleased structure''' The entry 5m5v is ON HOLD Authors: Muenzner, J., Graham, S.C. Description: Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatiti...

New page

'''Unreleased structure'''

The entry 5m5v is ON HOLD

Authors: Muenzner, J., Graham, S.C.

Description: Clathrin heavy chain N-terminal domain bound to a clathrin-box motif from hepatitis D virus large antigen (clade 2)
[[Category: Unreleased Structures]]
[[Category: Graham, S.C]]
[[Category: Muenzner, J]]