5m6a - Revision history

OCA at 18:27, 1 November 2023

OCA — Wed, 01 Nov 2023 18:27:26 GMT

←Older revision		Revision as of 18:27, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='5m6a' size='340' side='right'caption='[[5m6a]], [[Resolution\|resolution]] 1.64Å' scene=''>		<StructureSection load='5m6a' size='340' side='right'caption='[[5m6a]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m6a]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5M6A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M6A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.64Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [~~http~~://pdbe.org/5m6a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [https://pdbe.org/5m6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [https://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 23:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bacarizo, J]]	+	[[Category: Bacarizo J]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Oberti, L]]	+	[[Category: Oberti L]]
-	[[Category: Ricagno, S]]	+	[[Category: Ricagno S]]
-	[[Category: Rognoni, P]]	+	[[Category: Rognoni P]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold]]~~	+
-	~~[[Category: Light chain amyloidosis]]~~	+
-	~~[[Category: Light chain dimer]]~~	+
-	~~[[Category: Protein aggregation~~]]	+

OCA at 11:02, 12 August 2020

OCA — Wed, 12 Aug 2020 11:02:23 GMT

←Older revision		Revision as of 11:02, 12 August 2020
Line 1:		Line 1:

	==Crystal structure of cardiotoxic Bence-Jones light chain dimer H9==		==Crystal structure of cardiotoxic Bence-Jones light chain dimer H9==
-	<StructureSection load='5m6a' size='340' side='right' caption='[[5m6a]], [[Resolution\|resolution]] 1.64Å' scene=''>	+	<StructureSection load='5m6a' size='340' side='right'caption='[[5m6a]], [[Resolution\|resolution]] 1.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m6a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M6A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m6a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M6A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [http://pdbe.org/5m6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [http://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [http://pdbe.org/5m6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [http://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Bacarizo, J]]		[[Category: Bacarizo, J]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]

OCA at 07:27, 13 December 2017

OCA — Wed, 13 Dec 2017 07:27:08 GMT

←Older revision		Revision as of 07:27, 13 December 2017
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [http://pdbe.org/5m6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [http://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [http://pdbe.org/5m6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [http://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the overproduction and the aggregation of monoclonal immunoglobulin light chains (LC) in target organs. Due to genetic rearrangement and somatic hypermutation, virtually, each AL patient presents a different amyloidogenic LC. Because of such complexity, the fine molecular determinants of LC aggregation propensity and proteotoxicity are, to date, unclear; significantly, their decoding requires investigating large sets of cases. Aiming to achieve generalizable observations, we systematically characterised a pool of thirteen sequence-diverse full length LCs. Eight amyloidogenic LCs were selected as responsible for severe cardiac symptoms in patients; five non-amyloidogenic LCs were isolated from patients affected by multiple myeloma. Our comprehensive approach (consisting of spectroscopic techniques, limited proteolysis, and X-ray crystallography) shows that low fold stability and high protein dynamics correlate with amyloidogenic LCs, while hydrophobicity, structural rearrangements and nature of the LC dimeric association interface (as observed in seven crystal structures here presented) do not appear to play a significant role in defining amyloid propensity. Based on the structural and biophysical data, our results highlight shared properties driving LC amyloid propensity, and these data will be instrumental for the design of synthetic inhibitors of LC aggregation.
		+
		+	Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.,Oberti L, Rognoni P, Barbiroli A, Lavatelli F, Russo R, Maritan M, Palladini G, Bolognesi M, Merlini G, Ricagno S Sci Rep. 2017 Dec 1;7(1):16809. doi: 10.1038/s41598-017-16953-7. PMID:29196671<ref>PMID:29196671</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5m6a" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:25, 15 November 2017

OCA — Wed, 15 Nov 2017 07:25:07 GMT

←Older revision		Revision as of 07:25, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5m6a ~~is ON HOLD until Oct 24 2018~~	+	==Crystal structure of cardiotoxic Bence-Jones light chain dimer H9==
-		+	<StructureSection load='5m6a' size='340' side='right' caption='[[5m6a]], [[Resolution\|resolution]] 1.64Å' scene=''>
-	~~Authors~~: ~~Oberti, L~~.~~, Rognoni, P~~.~~, Bacarizo, J~~.~~, Bolognesi, M~~.~~, Ricagno, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5m6a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6A FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of cardiotoxic Bence~~-~~Jones light chain dimer H9~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6a OCA], [http://pdbe.org/5m6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6a RCSB], [http://www.ebi.ac.uk/pdbsum/5m6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6a ProSAT]</span></td></tr>
-	[[Category: ~~Rognoni, P~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Bacarizo, J]]		[[Category: Bacarizo, J]]
		+	[[Category: Bolognesi, M]]
	[[Category: Oberti, L]]		[[Category: Oberti, L]]
	[[Category: Ricagno, S]]		[[Category: Ricagno, S]]
-	[[Category: ~~Bolognesi~~, M]]	+	[[Category: Rognoni, P]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]
		+	[[Category: Light chain amyloidosis]]
		+	[[Category: Light chain dimer]]
		+	[[Category: Protein aggregation]]

OCA at 07:57, 4 October 2017

OCA — Wed, 04 Oct 2017 07:57:44 GMT

←Older revision		Revision as of 07:57, 4 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5m6a is ON HOLD	+	The entry 5m6a is ON HOLD until Oct 24 2018

	Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S.		Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S.
Line 7:		Line 7:
	Description: Crystal structure of cardiotoxic Bence-Jones light chain dimer H9		Description: Crystal structure of cardiotoxic Bence-Jones light chain dimer H9
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bacarizo, J]]
-	[[Category: Ricagno, S]]
	[[Category: Rognoni, P]]		[[Category: Rognoni, P]]
		+	[[Category: Bacarizo, J]]
	[[Category: Oberti, L]]		[[Category: Oberti, L]]
		+	[[Category: Ricagno, S]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]

OCA at 10:56, 27 September 2017

OCA — Wed, 27 Sep 2017 10:56:08 GMT

←Older revision		Revision as of 10:56, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5m6a is ON HOLD ~~until Oct 24 2018~~	+	The entry 5m6a is ON HOLD

	Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S.		Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S.

OCA: Protected "5m6a" [edit=sysop:move=sysop]

OCA — Wed, 02 Nov 2016 16:02:43 GMT

Protected "5m6a" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:02, 2 November 2016

OCA: New page: '''Unreleased structure''' The entry 5m6a is ON HOLD until Oct 24 2018 Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. Description: Crystal structure of card...

OCA — Wed, 02 Nov 2016 16:02:41 GMT

New page: '''Unreleased structure''' The entry 5m6a is ON HOLD until Oct 24 2018 Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S. Description: Crystal structure of card...

New page

'''Unreleased structure'''

The entry 5m6a is ON HOLD until Oct 24 2018

Authors: Oberti, L., Rognoni, P., Bacarizo, J., Bolognesi, M., Ricagno, S.

Description: Crystal structure of cardiotoxic Bence-Jones light chain dimer H9
[[Category: Unreleased Structures]]
[[Category: Bacarizo, J]]
[[Category: Ricagno, S]]
[[Category: Rognoni, P]]
[[Category: Oberti, L]]
[[Category: Bolognesi, M]]