5m6s - Revision history

OCA at 18:27, 1 November 2023

OCA — Wed, 01 Nov 2023 18:27:53 GMT

←Older revision		Revision as of 18:27, 1 November 2023
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	<SX load='5m6s' size='340' side='right' viewer='molstar' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>		<SX load='5m6s' size='340' side='right' viewer='molstar' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5M6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M6S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [~~http~~://pdbe.org/5m6s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [https://pdbe.org/5m6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [https://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LPTN_ECOLI LPTN_ECOLI] Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site. This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB.[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Chick~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Clarke, J]]	+	[[Category: Clarke J]]
-	[[Category: Nickson~~, A A~~]]	+	[[Category: Nickson AA]]
-	[[Category: Nilsson~~, O B]]~~	+	[[Category: Nilsson OB]]
-	~~[[Category: R16]]~~	+
-	~~[[Category: Spectrin]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 20:55, 10 April 2020

OCA — Fri, 10 Apr 2020 20:55:07 GMT

←Older revision		Revision as of 20:55, 10 April 2020
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	<SX load='5m6s' size='340' side='right' viewer='molstar' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>		<SX load='5m6s' size='340' side='right' viewer='molstar' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M6S FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:04, 6 March 2020

OCA — Fri, 06 Mar 2020 19:04:06 GMT

←Older revision		Revision as of 19:04, 6 March 2020
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	==folding intermediate of spectrin R16==		==folding intermediate of spectrin R16==
-	<~~StructureSection~~ load='5m6s' size='340' side='right' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>	+	<SX load='5m6s' size='340' side='right' viewer='molstar' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6S FirstGlance]. <br>		<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6S FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5m6s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5m6s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Spectrin\|Spectrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Clarke, J]]		[[Category: Clarke, J]]
	[[Category: Nickson, A A]]		[[Category: Nickson, A A]]

OCA at 03:34, 16 November 2017

OCA — Thu, 16 Nov 2017 03:34:06 GMT

←Older revision		Revision as of 03:34, 16 November 2017
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	<StructureSection load='5m6s' size='340' side='right' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>		<StructureSection load='5m6s' size='340' side='right' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6S FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
	[[Category: Clarke, J]]		[[Category: Clarke, J]]
	[[Category: Nickson, A A]]		[[Category: Nickson, A A]]

OCA at 11:18, 1 February 2017

OCA — Wed, 01 Feb 2017 11:18:29 GMT

←Older revision		Revision as of 11:18, 1 February 2017
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	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	How do the key features of protein folding, elucidated from studies on native, isolated proteins, manifest in cotranslational folding on the ribosome? Using a well-characterized family of homologous alpha-helical proteins with a range of biophysical properties, we show that spectrin domains can fold vectorially on the ribosome and may do so via a pathway different from that of the isolated domain. We use cryo-EM to reveal a folded or partially folded structure, formed in the vestibule of the ribosome. Our results reveal that it is not possible to predict which domains will fold within the ribosome on the basis of the folding behavior of isolated domains; instead, we propose that a complex balance of the rate of folding, the rate of translation and the lifetime of folded or partly folded states will determine whether folding occurs cotranslationally on actively translating ribosomes.
		+
		+	Cotranslational folding of spectrin domains via partially structured states.,Nilsson OB, Nickson AA, Hollins JJ, Wickles S, Steward A, Beckmann R, von Heijne G, Clarke J Nat Struct Mol Biol. 2017 Jan 23. doi: 10.1038/nsmb.3355. PMID:28112730<ref>PMID:28112730</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5m6s" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:34, 18 January 2017

OCA — Wed, 18 Jan 2017 16:34:11 GMT

←Older revision		Revision as of 16:34, 18 January 2017
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-	'''Unreleased structure'''

-	~~The entry 5m6s is ON HOLD until Paper Publication~~	+	==folding intermediate of spectrin R16==
-		+	<StructureSection load='5m6s' size='340' side='right' caption='[[5m6s]], [[Resolution\|resolution]] 4.80Å' scene=''>
-	~~Authors: Nilsson, O.B., Nickson, A.A., Clarke, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5m6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6S FirstGlance]. <br>
-	~~Description:~~ folding intermediate of spectrin R16	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6s OCA], [http://pdbe.org/5m6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6s RCSB], [http://www.ebi.ac.uk/pdbsum/5m6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6s ProSAT]</span></td></tr>
-	[[~~Category: Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Nilsson, O~~.B]]	+	__TOC__
-	[[~~Category~~: ~~Nickson~~, A.A]]	+	</StructureSection>
	[[Category: Clarke, J]]		[[Category: Clarke, J]]
		+	[[Category: Nickson, A A]]
		+	[[Category: Nilsson, O B]]
		+	[[Category: R16]]
		+	[[Category: Spectrin]]
		+	[[Category: Structural protein]]

OCA at 18:41, 22 December 2016

OCA — Thu, 22 Dec 2016 18:41:53 GMT

←Older revision		Revision as of 18:41, 22 December 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5m6s is ON HOLD	+	The entry 5m6s is ON HOLD until Paper Publication

	Authors: Nilsson, O.B., Nickson, A.A., Clarke, J.		Authors: Nilsson, O.B., Nickson, A.A., Clarke, J.

OCA: Protected "5m6s" [edit=sysop:move=sysop]

OCA — Wed, 02 Nov 2016 16:04:20 GMT

Protected "5m6s" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:04, 2 November 2016

OCA: New page: '''Unreleased structure''' The entry 5m6s is ON HOLD Authors: Nilsson, O.B., Nickson, A.A., Clarke, J. Description: folding intermediate of spectrin R16 [[Category: Unreleased Structur...

OCA — Wed, 02 Nov 2016 16:04:18 GMT

New page: '''Unreleased structure''' The entry 5m6s is ON HOLD Authors: Nilsson, O.B., Nickson, A.A., Clarke, J. Description: folding intermediate of spectrin R16 [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 5m6s is ON HOLD

Authors: Nilsson, O.B., Nickson, A.A., Clarke, J.

Description: folding intermediate of spectrin R16
[[Category: Unreleased Structures]]
[[Category: Nilsson, O.B]]
[[Category: Nickson, A.A]]
[[Category: Clarke, J]]