5m8o - Revision history

OCA at 18:30, 1 November 2023

OCA — Wed, 01 Nov 2023 18:30:43 GMT

←Older revision		Revision as of 18:30, 1 November 2023
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	<StructureSection load='5m8o' size='340' side='right'caption='[[5m8o]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5m8o' size='340' side='right'caption='[[5m8o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m8o]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m8o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M8O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TR:2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE'>0TR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TYRP1, CAS2, TYRP, TYRRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0TR:2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE'>0TR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8o OCA], [~~http~~://pdbe.org/5m8o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m8o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m8o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8o OCA], [https://pdbe.org/5m8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m8o RCSB], [https://www.ebi.ac.uk/pdbsum/5m8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8o ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147]	+	[https://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dijkstra~~, B W~~]]	+	[[Category: Dijkstra BW]]
-	[[Category: Lai, X]]	+	[[Category: Lai X]]
-	[[Category: Soler-Lopez, M]]	+	[[Category: Soler-Lopez M]]
-	[[Category: Wichers~~, H J]]~~	+	[[Category: Wichers HJ]]
-	~~[[Category: Human tyrosinase related protein 1]]~~	+
-	~~[[Category: Melanin biosynthesis]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tyrosinase]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 06:34, 16 October 2019

OCA — Wed, 16 Oct 2019 06:34:53 GMT

←Older revision		Revision as of 06:34, 16 October 2019
Line 1:		Line 1:

	==Crystal structure of human tyrosinase related protein 1 in complex with tropolone==		==Crystal structure of human tyrosinase related protein 1 in complex with tropolone==
-	<StructureSection load='5m8o' size='340' side='right' caption='[[5m8o]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5m8o' size='340' side='right'caption='[[5m8o]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m8o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M8O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m8o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M8O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TR:2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE'>0TR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TR:2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE'>0TR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TYRP1, CAS2, TYRP, TYRRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8o OCA], [http://pdbe.org/5m8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8o RCSB], [http://www.ebi.ac.uk/pdbsum/5m8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8o OCA], [http://pdbe.org/5m8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8o RCSB], [http://www.ebi.ac.uk/pdbsum/5m8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8o ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dijkstra, B W]]		[[Category: Dijkstra, B W]]
	[[Category: Lai, X]]		[[Category: Lai, X]]

OCA at 09:04, 9 August 2017

OCA — Wed, 09 Aug 2017 09:04:51 GMT

←Older revision		Revision as of 09:04, 9 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5m8o is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human tyrosinase related protein 1 in complex with tropolone==
		+	<StructureSection load='5m8o' size='340' side='right' caption='[[5m8o]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5m8o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M8O FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0TR:2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE'>0TR</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8o OCA], [http://pdbe.org/5m8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8o RCSB], [http://www.ebi.ac.uk/pdbsum/5m8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8o ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tyrosinase-related protein 1 (TYRP1) is one of three tyrosinase-like glycoenzymes in human melanocytes that are key to the production of melanin, the compound responsible for the pigmentation of skin, eye, and hair. Difficulties with producing these enzymes in pure form have hampered the understanding of their activity and the effect of mutations that cause albinism and pigmentation disorders. Herein we show that the typical tyrosinase-like subdomain of TYRP1 contains two zinc ions in the active site instead of copper ions as found in tyrosinases, which explains why TYRP1 does not exhibit tyrosinase redox activity. In addition, the structures reveal for the first time that the Cys-rich subdomain, which is unique to vertebrate melanogenic proteins, has an epidermal growth factor-like fold and is tightly associated with the tyrosinase subdomain. Our structures suggest that most albinism-related mutations of TYRP1 affect its stability or activity.

-	~~Authors: Lai~~, X., Soler-Lopez, M., ~~Wichers, H~~.J.~~, Dijkstra, B~~.W.	+	Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis.,Lai X, Wichers HJ, Soler-Lopez M, Dijkstra BW Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. doi: 10.1002/anie.201704616., Epub 2017 Jul 17. PMID:28661582<ref>PMID:28661582</ref>

-	~~Description: Crystal structure~~ of ~~human tyrosinase related protein 1 in complex with tropolone~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Wichers, H.J]]~~	+	<div class="pdbe-citations 5m8o" style="background-color:#fffaf0;"></div>
-	[[Category: Dijkstra, B.W]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dijkstra, B W]]
	[[Category: Lai, X]]		[[Category: Lai, X]]
	[[Category: Soler-Lopez, M]]		[[Category: Soler-Lopez, M]]
		+	[[Category: Wichers, H J]]
		+	[[Category: Human tyrosinase related protein 1]]
		+	[[Category: Melanin biosynthesis]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tyrosinase]]
		+	[[Category: Unknown function]]

OCA at 11:07, 9 March 2017

OCA — Thu, 09 Mar 2017 11:07:30 GMT

←Older revision		Revision as of 11:07, 9 March 2017
Line 7:		Line 7:
	Description: Crystal structure of human tyrosinase related protein 1 in complex with tropolone		Description: Crystal structure of human tyrosinase related protein 1 in complex with tropolone
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Wichers, H.J]]
	[[Category: Dijkstra, B.W]]		[[Category: Dijkstra, B.W]]
	[[Category: Lai, X]]		[[Category: Lai, X]]
	[[Category: Soler-Lopez, M]]		[[Category: Soler-Lopez, M]]
-	[[Category: Wichers, H.J]]

OCA: Protected "5m8o" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 16:30:02 GMT

Protected "5m8o" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:30, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5m8o is ON HOLD until Paper Publication Authors: Lai, X., Soler-Lopez, M., Wichers, H.J., Dijkstra, B.W. Description: Crystal structure of human ty...

OCA — Fri, 09 Dec 2016 16:30:01 GMT

New page: '''Unreleased structure''' The entry 5m8o is ON HOLD until Paper Publication Authors: Lai, X., Soler-Lopez, M., Wichers, H.J., Dijkstra, B.W. Description: Crystal structure of human ty...

New page

'''Unreleased structure'''

The entry 5m8o is ON HOLD until Paper Publication

Authors: Lai, X., Soler-Lopez, M., Wichers, H.J., Dijkstra, B.W.

Description: Crystal structure of human tyrosinase related protein 1 in complex with tropolone
[[Category: Unreleased Structures]]
[[Category: Dijkstra, B.W]]
[[Category: Lai, X]]
[[Category: Soler-Lopez, M]]
[[Category: Wichers, H.J]]