5m95 - Revision history

OCA at 12:29, 22 February 2023

OCA — Wed, 22 Feb 2023 12:29:11 GMT

←Older revision		Revision as of 12:29, 22 February 2023
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	==STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE==		==STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE==
-	<StructureSection load='5m95' size='340' side='right' caption='[[5m95]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='5m95' size='340' side='right'caption='[[5m95]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m95]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_27840 Atcc 27840~~] and [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M95 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m95]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Staphylococcus_capitis Staphylococcus capitis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4wgw 4wgw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M95 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wgv\|4wgv]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m95 OCA], [https://pdbe.org/5m95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m95 RCSB], [https://www.ebi.ac.uk/pdbsum/5m95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m95 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntH, BN1317_80025, SCAPIOD100025, SCAPIOD110024, SCAPIOD130025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29388 ATCC 27840])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m95 OCA], [~~http~~://pdbe.org/5m95 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m95 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m95 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m95 ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/A0A0S4MEX1_STACP A0A0S4MEX1_STACP]] H(+)-stimulated, divalent metal cation uptake system.[HAMAP-Rule:MF_00221]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 19:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 27840]]~~	+	[[Category: Lama glama]]
-	~~[[Category: Camelus~~ glama]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dutzler, R~~]]	+	[[Category: Staphylococcus capitis]]
-	[[Category: ~~Ehrnstorfer, I A~~]]	+	[[Category: Dutzler R]]
-	[[Category: ~~Geertsma, E~~ R]]	+	[[Category: Ehrnstorfer IA]]
-	[[Category: ~~Pardon, E~~]]	+	[[Category: Geertsma ER]]
-	[[Category: ~~Steyaert, J~~]]	+	[[Category: Pardon E]]
-	[[Category: ~~Dmt~~]]	+	[[Category: Steyaert J]]
-	[[Category: ~~Leut fold]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Nramp]]~~	+
-	~~[[Category: Slc11]]~~	+
-	~~[[Category: Transition metal ion]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 06:25, 9 May 2018

OCA — Wed, 09 May 2018 06:25:52 GMT

←Older revision		Revision as of 06:25, 9 May 2018
Line 3:		Line 3:
	<StructureSection load='5m95' size='340' side='right' caption='[[5m95]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='5m95' size='340' side='right' caption='[[5m95]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m95]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M95 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m95]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27840 Atcc 27840] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M95 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wgv\|4wgv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wgv\|4wgv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mntH, BN1317_80025, SCAPIOD100025, SCAPIOD110024, SCAPIOD130025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29388 ATCC 27840])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m95 OCA], [http://pdbe.org/5m95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m95 RCSB], [http://www.ebi.ac.uk/pdbsum/5m95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m95 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m95 OCA], [http://pdbe.org/5m95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m95 RCSB], [http://www.ebi.ac.uk/pdbsum/5m95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m95 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5m95" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5m95" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 27840]]
		+	[[Category: Camelus glama]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]
	[[Category: Ehrnstorfer, I A]]		[[Category: Ehrnstorfer, I A]]

OCA: Protected "5m95" [edit=sysop:move=sysop]

OCA — Sat, 10 Dec 2016 18:38:07 GMT

Protected "5m95" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:38, 10 December 2016

OCA: New page: ==STAPHYLOCOCCUS CAPITIS DIVALENT METAL ION TRANSPORTER (DMT) IN COMPLEX WITH MANGANESE== == Structural highlights ==
<table><tr><td colspan='2'>[[5m95]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M95 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M95 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wgv|4wgv]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m95 OCA], [http://pdbe.org/5m95 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m95 RCSB], [http://www.ebi.ac.uk/pdbsum/5m95 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m95 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/A0A0S4MEX1_STACP A0A0S4MEX1_STACP]] H(+)-stimulated, divalent metal cation uptake system.[HAMAP-Rule:MF_00221]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Members of the SLC11 (NRAMP) family transport iron and other transition-metal ions across cellular membranes. These membrane proteins are present in all kingdoms of life with a high degree of sequence conservation. To gain insight into the determinants of ion selectivity, we have determined the crystal structure of Staphylococcus capitis DMT (ScaDMT), a close prokaryotic homolog of the family. ScaDMT shows a familiar architecture that was previously identified in the amino acid permease LeuT. The protein adopts an inward-facing conformation with a substrate-binding site located in the center of the transporter. This site is composed of conserved residues, which coordinate Mn2+, Fe2+ and Cd2+ but not Ca2+. Mutations of interacting residues affect ion binding and transport in both ScaDMT and human DMT1. Our study thus reveals a conserved mechanism for transition-metal ion selectivity within the SLC11 family.

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.,Ehrnstorfer IA, Geertsma ER, Pardon E, Steyaert J, Dutzler R Nat Struct Mol Biol. 2014 Oct 19. doi: 10.1038/nsmb.2904. PMID:25326704<ref>PMID:25326704</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5m95" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Dutzler, R]]
[[Category: Ehrnstorfer, I A]]
[[Category: Geertsma, E R]]
[[Category: Pardon, E]]
[[Category: Steyaert, J]]
[[Category: Dmt]]
[[Category: Leut fold]]
[[Category: Membrane protein]]
[[Category: Nramp]]
[[Category: Slc11]]
[[Category: Transition metal ion]]
[[Category: Transport protein]]
[[Category: Transporter]]