5me6 - Revision history

OCA at 18:40, 1 November 2023

OCA — Wed, 01 Nov 2023 18:40:33 GMT

←Older revision		Revision as of 18:40, 1 November 2023
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	<StructureSection load='5me6' size='340' side='right'caption='[[5me6]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5me6' size='340' side='right'caption='[[5me6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5me6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ME6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5me6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucumis_melo Cucumis melo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ME6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5me6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me6 OCA], [~~http~~://pdbe.org/5me6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5me6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5me6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5me6 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5me6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me6 OCA], [https://pdbe.org/5me6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5me6 RCSB], [https://www.ebi.ac.uk/pdbsum/5me6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5me6 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IF4E1_CUCME IF4E1_CUCME] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:17026540, PubMed:28522457). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:17026540, PubMed:28522457). Key component of recessive resistance to potyviruses and Tombusviridae genus Carmovirus such as melon necrotic spot virus (MNSV) (PubMed:17026540).<ref>PMID:17026540</ref> <ref>PMID:28522457</ref> (Microbial infection) Susceptibility host factor required for viral infection by recruiting viral RNAs, including uncapped and non-polyadenylated RNA, to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).<ref>PMID:17026540</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cucumis melo]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aranda-Regules, M]]	+	[[Category: Aranda-Regules M]]
-	[[Category: Miras, M]]	+	[[Category: Miras M]]
-	[[Category: Querol-Audi, J]]	+	[[Category: Querol-Audi J]]
-	[[Category: Silva, C]]	+	[[Category: Silva C]]
-	[[Category: Verdaguer, N]]	+	[[Category: Verdaguer N]]
-	~~[[Category: C. melo]]~~	+
-	~~[[Category: Cap analog]]~~	+
-	~~[[Category: Eif4e]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 07:16, 19 August 2020

OCA — Wed, 19 Aug 2020 07:16:27 GMT

←Older revision		Revision as of 07:16, 19 August 2020
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	==Crystal Structure of eiF4E from C. melo bound to a CAP analog==		==Crystal Structure of eiF4E from C. melo bound to a CAP analog==
-	<StructureSection load='5me6' size='340' side='right' caption='[[5me6]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='5me6' size='340' side='right'caption='[[5me6]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5me6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ME6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5me6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ME6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5me6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me6 OCA], [http://pdbe.org/5me6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5me6 RCSB], [http://www.ebi.ac.uk/pdbsum/5me6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5me6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5me6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me6 OCA], [http://pdbe.org/5me6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5me6 RCSB], [http://www.ebi.ac.uk/pdbsum/5me6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5me6 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5me6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5me6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Aranda-Regules, M]]		[[Category: Aranda-Regules, M]]
	[[Category: Miras, M]]		[[Category: Miras, M]]

OCA at 11:08, 24 August 2017

OCA — Thu, 24 Aug 2017 11:08:02 GMT

←Older revision		Revision as of 11:08, 24 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5me6 is ~~ON HOLD~~	+	==Crystal Structure of eiF4E from C. melo bound to a CAP analog==
		+	<StructureSection load='5me6' size='340' side='right' caption='[[5me6]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5me6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ME6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ME6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5me6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5me6 OCA], [http://pdbe.org/5me6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5me6 RCSB], [http://www.ebi.ac.uk/pdbsum/5me6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5me6 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The association-dissociation of the cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a key control step in eukaryotic translation. The paradigm on the eIF4E-eIF4G interaction states that eIF4G binds to the dorsal surface of eIF4E through a single canonical alpha-helical motif, while metazoan eIF4E-binding proteins (m4E-BPs) advantageously compete against eIF4G via bimodal interactions involving this canonical motif and a second noncanonical motif of the eIF4E surface. Metazoan eIF4Gs share this extended binding interface with m4E-BPs, with significant implications on the understanding of translation regulation and the design of therapeutic molecules. Here we show the high-resolution structure of melon (Cucumis melo) eIF4E in complex with a melon eIF4G peptide and propose the first eIF4E-eIF4G structural model for plants. Our structural data together with functional analyses demonstrate that plant eIF4G binds to eIF4E through both the canonical and noncanonical motifs, similarly to metazoan eIF4E-eIF4G complexes. As in the case of metazoan eIF4E-eIF4G, this may have very important practical implications, as plant eIF4E-eIF4G is also involved in a significant number of plant diseases. In light of our results, a universal eukaryotic bipartite mode of binding to eIF4E is proposed.

-	~~Authors: Querol-Audi, J~~., ~~Silva~~, C., ~~Miras, M.~~, Aranda~~-Regules~~, M., ~~Verdaguer, N~~.	+	Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation.,Miras M, Truniger V, Silva C, Verdaguer N, Aranda MA, Querol-Audi J Plant Physiol. 2017 Jul;174(3):1476-1491. doi: 10.1104/pp.17.00193. Epub 2017 May, 18. PMID:28522457<ref>PMID:28522457</ref>

-	~~Description: Crystal Structure~~ of ~~eiF4E from C~~. ~~melo bound to a CAP analog~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Querol~~-~~Audi, J]]~~	+	<div class="pdbe-citations 5me6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aranda-Regules, M]]		[[Category: Aranda-Regules, M]]
-	[[Category: Verdaguer, N]]
	[[Category: Miras, M]]		[[Category: Miras, M]]
		+	[[Category: Querol-Audi, J]]
	[[Category: Silva, C]]		[[Category: Silva, C]]
		+	[[Category: Verdaguer, N]]
		+	[[Category: C. melo]]
		+	[[Category: Cap analog]]
		+	[[Category: Eif4e]]
		+	[[Category: Translation]]

OCA at 11:13, 9 March 2017

OCA — Thu, 09 Mar 2017 11:13:33 GMT

←Older revision		Revision as of 11:13, 9 March 2017
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	Description: Crystal Structure of eiF4E from C. melo bound to a CAP analog		Description: Crystal Structure of eiF4E from C. melo bound to a CAP analog
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Aranda-Regules, M]]
-	[[Category: Silva, C]]
	[[Category: Querol-Audi, J]]		[[Category: Querol-Audi, J]]
		+	[[Category: Aranda-Regules, M]]
	[[Category: Verdaguer, N]]		[[Category: Verdaguer, N]]
	[[Category: Miras, M]]		[[Category: Miras, M]]
		+	[[Category: Silva, C]]

OCA: Protected "5me6" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 16:42:40 GMT

Protected "5me6" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:42, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5me6 is ON HOLD Authors: Querol-Audi, J., Silva, C., Miras, M., Aranda-Regules, M., Verdaguer, N. Description: Crystal Structure of eiF4E from C. m...

OCA — Fri, 09 Dec 2016 16:42:39 GMT

New page: '''Unreleased structure''' The entry 5me6 is ON HOLD Authors: Querol-Audi, J., Silva, C., Miras, M., Aranda-Regules, M., Verdaguer, N. Description: Crystal Structure of eiF4E from C. m...

New page

'''Unreleased structure'''

The entry 5me6 is ON HOLD

Authors: Querol-Audi, J., Silva, C., Miras, M., Aranda-Regules, M., Verdaguer, N.

Description: Crystal Structure of eiF4E from C. melo bound to a CAP analog
[[Category: Unreleased Structures]]
[[Category: Aranda-Regules, M]]
[[Category: Silva, C]]
[[Category: Querol-Audi, J]]
[[Category: Verdaguer, N]]
[[Category: Miras, M]]