5mha - Revision history

OCA at 09:12, 28 December 2022

OCA — Wed, 28 Dec 2022 09:12:16 GMT

←Older revision		Revision as of 09:12, 28 December 2022
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	<StructureSection load='5mha' size='340' side='right'caption='[[5mha]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='5mha' size='340' side='right'caption='[[5mha]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mha]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MHA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mha]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloferax_mediterranei_ATCC_33500 Haloferax mediterranei ATCC 33500]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=7N6:(2R)-2-hydroxyhexanoic+acid'>7N6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=7N6:(2R)-2-hydroxyhexanoic+acid'>7N6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mh5\|5mh5]], [[5mh6\|5mh6]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mha OCA], [https://pdbe.org/5mha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mha RCSB], [https://www.ebi.ac.uk/pdbsum/5mha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mha ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mha OCA], [~~http~~://pdbe.org/5mha PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mha RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mha PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mha ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT]] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref>	+	[https://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Haloferax mediterranei ATCC 33500]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, P J~~]]	+	[[Category: Baker PJ]]
-	[[Category: Bisson, C]]	+	[[Category: Bisson C]]
-	[[Category: ~~Ferrer,~~ J]]	+	[[Category: Domenech Perez J]]
-	[[Category: ~~Harding, S E~~]]	+	[[Category: Ferrer J]]
-	[[Category: ~~Perez, J Domenech~~]]	+	[[Category: Harding SE]]
-	[[Category: Pramanpol, N]]	+	[[Category: Pramanpol N]]
-	[[Category: Rice~~, D W]]~~	+	[[Category: Rice DW]]
-	~~[[Category: Chiral specificity]]~~	+
-	~~[[Category: D-2-hydroxyacid dehydrogenase]]~~	+
-	~~[[Category: Halophile]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reaction mechanism~~]]	+

OCA at 07:19, 19 August 2020

OCA — Wed, 19 Aug 2020 07:19:37 GMT

←Older revision		Revision as of 07:19, 19 August 2020
Line 1:		Line 1:

	==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)==		==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)==
-	<StructureSection load='5mha' size='340' side='right' caption='[[5mha]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='5mha' size='340' side='right'caption='[[5mha]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mha]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MHA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mha]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MHA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=7N6:(2R)-2-hydroxyhexanoic+acid'>7N6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=7N6:(2R)-2-hydroxyhexanoic+acid'>7N6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mh5\|5mh5]], [[5mh6\|5mh6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mh5\|5mh5]], [[5mh6\|5mh6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mha OCA], [http://pdbe.org/5mha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mha RCSB], [http://www.ebi.ac.uk/pdbsum/5mha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mha ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mha OCA], [http://pdbe.org/5mha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mha RCSB], [http://www.ebi.ac.uk/pdbsum/5mha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mha ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baker, P J]]		[[Category: Baker, P J]]
	[[Category: Bisson, C]]		[[Category: Bisson, C]]

OCA at 06:07, 9 May 2018

OCA — Wed, 09 May 2018 06:07:50 GMT

←Older revision		Revision as of 06:07, 9 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5mha is ON HOLD until Paper Publication~~	+	==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)==
-		+	<StructureSection load='5mha' size='340' side='right' caption='[[5mha]], [[Resolution\|resolution]] 1.57Å' scene=''>
-	~~Authors: Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mha]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MHA FirstGlance]. <br>
-	~~Description:~~ D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=7N6:(2R)-2-hydroxyhexanoic+acid'>7N6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mh5\|5mh5]], [[5mh6\|5mh6]]</td></tr>
-	[[Category: ~~Harding~~, ~~S.E~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mha OCA], [http://pdbe.org/5mha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mha RCSB], [http://www.ebi.ac.uk/pdbsum/5mha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mha ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT]] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Baker, P J]]
		+	[[Category: Bisson, C]]
	[[Category: Ferrer, J]]		[[Category: Ferrer, J]]
-	[[Category: ~~Bisson~~, C]]	+	[[Category: Harding, S E]]
-	[[Category: ~~Baker~~, P.J]]	+	[[Category: Perez, J Domenech]]
-	~~[[Category:~~ Domenech ~~Perez, J]]~~	+
-	~~[[Category: Rice, D.W~~]]	+
	[[Category: Pramanpol, N]]		[[Category: Pramanpol, N]]
		+	[[Category: Rice, D W]]
		+	[[Category: Chiral specificity]]
		+	[[Category: D-2-hydroxyacid dehydrogenase]]
		+	[[Category: Halophile]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reaction mechanism]]

OCA at 11:18, 9 March 2017

OCA — Thu, 09 Mar 2017 11:18:26 GMT

←Older revision		Revision as of 11:18, 9 March 2017
Line 7:		Line 7:
	Description: D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)		Description: D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Harding, S.E]]
		+	[[Category: Ferrer, J]]
	[[Category: Bisson, C]]		[[Category: Bisson, C]]
	[[Category: Baker, P.J]]		[[Category: Baker, P.J]]
	[[Category: Domenech Perez, J]]		[[Category: Domenech Perez, J]]
	[[Category: Rice, D.W]]		[[Category: Rice, D.W]]
-	[[Category: Harding, S.E]]
-	[[Category: Ferrer, J]]
	[[Category: Pramanpol, N]]		[[Category: Pramanpol, N]]

OCA: Protected "5mha" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 16:51:54 GMT

Protected "5mha" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:51, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5mha is ON HOLD until Paper Publication Authors: Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J. ...

OCA — Fri, 09 Dec 2016 16:51:53 GMT

New page: '''Unreleased structure''' The entry 5mha is ON HOLD until Paper Publication Authors: Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J. ...

New page

'''Unreleased structure'''

The entry 5mha is ON HOLD until Paper Publication

Authors: Bisson, C., Baker, P.J., Domenech Perez, J., Pramanpol, N., Harding, S.E., Rice, D.W., Ferrer, J.

Description: D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with a mixture of 2-ketohexanoic acid and 2-hydroxyhexanoic acid, and NADPH (1.57 A resolution)
[[Category: Unreleased Structures]]
[[Category: Bisson, C]]
[[Category: Baker, P.J]]
[[Category: Domenech Perez, J]]
[[Category: Rice, D.W]]
[[Category: Harding, S.E]]
[[Category: Ferrer, J]]
[[Category: Pramanpol, N]]