5mlz - Revision history

OCA at 17:37, 8 November 2023

OCA — Wed, 08 Nov 2023 17:37:18 GMT

←Older revision		Revision as of 17:37, 8 November 2023
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	<StructureSection load='5mlz' size='340' side='right'caption='[[5mlz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5mlz' size='340' side='right'caption='[[5mlz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mlz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mlz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlz OCA], [~~http~~://pdbe.org/5mlz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mlz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mlz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlz ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlz OCA], [https://pdbe.org/5mlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mlz RCSB], [https://www.ebi.ac.uk/pdbsum/5mlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DPM1_PYRFU DPM1_PYRFU] Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.<ref>PMID:28743912</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Divne, C~~]]	+	[[Category: Pyrococcus furiosus DSM 3638]]
-	[[Category: ~~Gandini, R~~]]	+	[[Category: Divne C]]
-	[[Category: ~~Reichenbach, T~~]]	+	[[Category: Gandini R]]
-	[[Category: ~~Tan,~~ T C]]	+	[[Category: Reichenbach T]]
-	[[Category: ~~Dolichol phosphate mannose synthase]]~~	+	[[Category: Tan TC]]
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Integral membrane protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein glycosylation~~]]	+

OCA at 07:23, 19 August 2020

OCA — Wed, 19 Aug 2020 07:23:04 GMT

←Older revision		Revision as of 07:23, 19 August 2020
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	==Dolichyl phosphate mannose synthase in complex with GDP and Mg2+==		==Dolichyl phosphate mannose synthase in complex with GDP and Mg2+==
-	<StructureSection load='5mlz' size='340' side='right' caption='[[5mlz]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5mlz' size='340' side='right'caption='[[5mlz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mlz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mlz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MLZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlz OCA], [http://pdbe.org/5mlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlz RCSB], [http://www.ebi.ac.uk/pdbsum/5mlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlz OCA], [http://pdbe.org/5mlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlz RCSB], [http://www.ebi.ac.uk/pdbsum/5mlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Divne, C]]		[[Category: Divne, C]]
	[[Category: Gandini, R]]		[[Category: Gandini, R]]

OCA at 09:01, 9 August 2017

OCA — Wed, 09 Aug 2017 09:01:18 GMT

←Older revision		Revision as of 09:01, 9 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5mlz is ~~ON HOLD until Paper~~ Publication	+	==Dolichyl phosphate mannose synthase in complex with GDP and Mg2+==
		+	<StructureSection load='5mlz' size='340' side='right' caption='[[5mlz]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mlz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MLZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlz OCA], [http://pdbe.org/5mlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlz RCSB], [http://www.ebi.ac.uk/pdbsum/5mlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein glycosylation is a critical protein modification. In biogenic membranes of eukaryotes and archaea, these reactions require activated mannose in the form of the lipid conjugate dolichylphosphate mannose (Dol-P-Man). The membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier Dol-P, to yield Dol-P-Man. Failure to produce or utilize Dol-P-Man compromises organism viability, and in humans, several mutations in the human dpm1 gene lead to congenital disorders of glycosylation (CDG). Here, we report three high-resolution crystal structures of archaeal DPMS from Pyrococcus furiosus, in complex with nucleotide, donor, and glycolipid product. The structures offer snapshots along the catalytic cycle, and reveal how lipid binding couples to movements of interface helices, metal binding, and acceptor loop dynamics to control critical events leading to Dol-P-Man synthesis. The structures also rationalize the loss of dolichylphosphate mannose synthase function in dpm1-associated CDG.The generation of glycolipid dolichylphosphate mannose (Dol-P-Man) is a critical step for protein glycosylation and GPI anchor synthesis. Here the authors report the structure of dolichylphosphate mannose synthase in complex with bound nucleotide and donor to provide insight into the mechanism of Dol-P-Man synthesis.

-	~~Authors~~:	+	Structural basis for dolichylphosphate mannose biosynthesis.,Gandini R, Reichenbach T, Tan TC, Divne C Nat Commun. 2017 Jul 25;8(1):120. doi: 10.1038/s41467-017-00187-2. PMID:28743912<ref>PMID:28743912</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mlz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Divne, C]]
		+	[[Category: Gandini, R]]
		+	[[Category: Reichenbach, T]]
		+	[[Category: Tan, T C]]
		+	[[Category: Dolichol phosphate mannose synthase]]
		+	[[Category: Enzyme]]
		+	[[Category: Integral membrane protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein glycosylation]]

OCA at 14:59, 1 February 2017

OCA — Wed, 01 Feb 2017 14:59:08 GMT

←Older revision		Revision as of 14:59, 1 February 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5mlz is ON HOLD	+	The entry 5mlz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5mlz" [edit=sysop:move=sysop]

OCA — Thu, 15 Dec 2016 16:29:03 GMT

Protected "5mlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:29, 15 December 2016

OCA: New page: '''Unreleased structure''' The entry 5mlz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 15 Dec 2016 16:29:02 GMT

New page: '''Unreleased structure''' The entry 5mlz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mlz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]