5moc - Revision history

OCA at 17:42, 8 November 2023

OCA — Wed, 08 Nov 2023 17:42:00 GMT

←Older revision		Revision as of 17:42, 8 November 2023
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	<StructureSection load='5moc' size='340' side='right'caption='[[5moc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5moc' size='340' side='right'caption='[[5moc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MOC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~TPO~~:~~PHOSPHOTHREONINE~~'>~~TPO~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [https://pdbe.org/5moc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [https://www.ebi.ac.uk/pdbsum/5moc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [~~http~~://pdbe.org/5moc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5moc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.	+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andrei, S]]	+	[[Category: Andrei S]]
-	[[Category: Leysen, S]]	+	[[Category: Leysen S]]
-	[[Category: Ottmann, C]]	+	[[Category: Ottmann C]]
-	~~[[Category: 14-3-3 p53 c-terminus]]~~	+
-	~~[[Category: Antitumor protein~~]]	+

OCA at 12:31, 13 March 2019

OCA — Wed, 13 Mar 2019 12:31:53 GMT

←Older revision		Revision as of 12:31, 13 March 2019
Line 1:		Line 1:

	==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==		==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
-	<StructureSection load='5moc' size='340' side='right' caption='[[5moc]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5moc' size='340' side='right'caption='[[5moc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [http://pdbe.org/5moc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [http://www.ebi.ac.uk/pdbsum/5moc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [http://pdbe.org/5moc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [http://www.ebi.ac.uk/pdbsum/5moc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5moc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5moc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Andrei, S]]		[[Category: Andrei, S]]
	[[Category: Leysen, S]]		[[Category: Leysen, S]]

OCA at 09:18, 4 October 2017

OCA — Wed, 04 Oct 2017 09:18:58 GMT

←Older revision		Revision as of 09:18, 4 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5moc is ~~ON HOLD~~	+	==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
		+	<StructureSection load='5moc' size='340' side='right' caption='[[5moc]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5moc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5moc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5moc OCA], [http://pdbe.org/5moc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5moc RCSB], [http://www.ebi.ac.uk/pdbsum/5moc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5moc ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	14-3-3 proteins are positive regulators of the tumor suppressor p53, the mutation of which is implicated in many human cancers. Current strategies for targeting of p53 involve restoration of wild-type function or inhibition of the interaction with MDM2, its key negative regulator. Despite the efficacy of these strategies, the alternate approach of stabilizing the interaction of p53 with positive regulators and, thus, enhancing tumor suppressor activity, has not been explored. Here, we report the first example of small-molecule stabilization of the 14-3-3 - p53 protein-protein interaction (PPI) and demonstrate the potential of this approach as a therapeutic modality. We also observed a disconnect between biophysical and crystallographic data in the presence of a stabilizing molecule, which is unusual in 14-3-3 PPIs.

-	~~Authors~~:	+	Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.,Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017, Aug 6. PMID:28640363<ref>PMID:28640363</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5moc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andrei, S]]
		+	[[Category: Leysen, S]]
		+	[[Category: Ottmann, C]]
		+	[[Category: 14-3-3 p53 c-terminus]]
		+	[[Category: Antitumor protein]]

OCA: Protected "5moc" [edit=sysop:move=sysop]

OCA — Thu, 22 Dec 2016 19:15:02 GMT

Protected "5moc" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:15, 22 December 2016

OCA: New page: '''Unreleased structure''' The entry 5moc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 22 Dec 2016 19:15:00 GMT

New page: '''Unreleased structure''' The entry 5moc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5moc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]