5msj - Revision history

OCA at 17:48, 8 November 2023

OCA — Wed, 08 Nov 2023 17:48:15 GMT

←Older revision		Revision as of 17:48, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='5msj' size='340' side='right'caption='[[5msj]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='5msj' size='340' side='right'caption='[[5msj]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5msj]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5msj]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MSJ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~1avo~~\|~~1avo~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msj OCA], [~~http~~://pdbe.org/5msj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5msj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5msj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5msj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msj OCA], [https://pdbe.org/5msj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5msj RCSB], [https://www.ebi.ac.uk/pdbsum/5msj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5msj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PSME1_MOUSE PSME1_MOUSE]] Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.	+	[https://www.uniprot.org/uniprot/PSME1_MOUSE PSME1_MOUSE] Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Groll, M~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Huber, E~~ M]]	+	[[Category: Groll M]]
-	[[Category: ~~Heptamer]]~~	+	[[Category: Huber EM]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Interferon-gamma]]~~	+
-	~~[[Category: Proteasome activator]]~~	+
-	~~[[Category: Regalpha]]~~	+
-	~~[[Category: Regulator]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:27, 19 August 2020

OCA — Wed, 19 Aug 2020 07:27:50 GMT

←Older revision		Revision as of 07:27, 19 August 2020
Line 1:		Line 1:

	==Mouse PA28alpha==		==Mouse PA28alpha==
-	<StructureSection load='5msj' size='340' side='right' caption='[[5msj]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='5msj' size='340' side='right'caption='[[5msj]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5msj]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5msj]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MSJ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1avo\|1avo]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1avo\|1avo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msj OCA], [http://pdbe.org/5msj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5msj RCSB], [http://www.ebi.ac.uk/pdbsum/5msj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5msj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msj OCA], [http://pdbe.org/5msj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5msj RCSB], [http://www.ebi.ac.uk/pdbsum/5msj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5msj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Groll, M]]		[[Category: Groll, M]]
	[[Category: Huber, E M]]		[[Category: Huber, E M]]

OCA at 10:58, 13 September 2017

OCA — Wed, 13 Sep 2017 10:58:43 GMT

←Older revision		Revision as of 10:58, 13 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5msj is ~~ON HOLD until Paper~~ Publication	+	==Mouse PA28alpha==
		+	<StructureSection load='5msj' size='340' side='right' caption='[[5msj]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5msj]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MSJ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1avo\|1avo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5msj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5msj OCA], [http://pdbe.org/5msj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5msj RCSB], [http://www.ebi.ac.uk/pdbsum/5msj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5msj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PSME1_MOUSE PSME1_MOUSE]] Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The heptameric proteasome activator (PA) 28alphabeta is known to modulate class I antigen processing by docking onto 20S proteasome core particles (CPs). The exact stoichiometry and arrangement of its alpha and beta subunits, however, is still controversial. Here we analyzed murine PA28 complexes regarding structure and assembly. Strikingly, PA28alpha, PA28beta, and PA28alphabeta preparations form heptamers, but solely PA28alpha and PA28alphabeta associate with CPs. Co-expression of alpha and beta yields one unique PA28alphabeta species with an unchangeable subunit composition. Structural data on PA28alpha, PA28beta, and PA28alphabeta up to 2.9 A resolution reveal a PA28alpha4beta3 complex with an alternating subunit arrangement and a single alpha-alpha interface. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species. Together, our data resolve subunit composition and arrangement of PA28alphabeta and clarify how an asymmetric heptamer can be assembled from two highly homologous subunits.

-	~~Authors~~:	+	The Mammalian Proteasome Activator PA28 Forms an Asymmetric alpha4beta3 Complex.,Huber EM, Groll M Structure. 2017 Aug 22. pii: S0969-2126(17)30247-2. doi:, 10.1016/j.str.2017.07.013. PMID:28867616<ref>PMID:28867616</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5msj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Groll, M]]
		+	[[Category: Huber, E M]]
		+	[[Category: Heptamer]]
		+	[[Category: Hydrolase]]
		+	[[Category: Interferon-gamma]]
		+	[[Category: Proteasome activator]]
		+	[[Category: Regalpha]]
		+	[[Category: Regulator]]
		+	[[Category: Structural protein]]

OCA at 15:10, 1 February 2017

OCA — Wed, 01 Feb 2017 15:10:25 GMT

←Older revision		Revision as of 15:10, 1 February 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5msj is ON HOLD	+	The entry 5msj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5msj" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 13:09:37 GMT

Protected "5msj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5msj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 13:09:35 GMT

New page: '''Unreleased structure''' The entry 5msj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5msj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]