5mu0 - Revision history

OCA at 17:49, 8 November 2023

OCA — Wed, 08 Nov 2023 17:49:47 GMT

←Older revision		Revision as of 17:49, 8 November 2023
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	<StructureSection load='5mu0' size='340' side='right'caption='[[5mu0]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5mu0' size='340' side='right'caption='[[5mu0]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MU0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU0 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [~~http~~://pdbe.org/5mu0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [https://pdbe.org/5mu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Dobritzsch, D]]	+	[[Category: Dobritzsch D]]
-	[[Category: Ge, C]]	+	[[Category: Ge C]]
-	[[Category: Holmdahl, R]]	+	[[Category: Holmdahl R]]
-	~~[[Category: Immune system~~]]	+

OCA at 07:29, 19 August 2020

OCA — Wed, 19 Aug 2020 07:29:00 GMT

←Older revision		Revision as of 07:29, 19 August 2020
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	==ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)==		==ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)==
-	<StructureSection load='5mu0' size='340' side='right' caption='[[5mu0]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5mu0' size='340' side='right'caption='[[5mu0]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MU0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MU0 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [http://pdbe.org/5mu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [http://pdbe.org/5mu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5mu0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5mu0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dobritzsch, D]]		[[Category: Dobritzsch, D]]

OCA at 10:38, 13 September 2017

OCA — Wed, 13 Sep 2017 10:38:04 GMT

←Older revision		Revision as of 10:38, 13 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5mu0 is ~~ON HOLD~~	+	==ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)==
		+	<StructureSection load='5mu0' size='340' side='right' caption='[[5mu0]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU0 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [http://pdbe.org/5mu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA. A mAb (ACC1) against citrullinated C1 was found to cross-react with several noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. Structural studies by X-ray crystallography showed that such recognition is governed by a shared structural motif "RG-TG" within all the epitopes, including electrostatic potential-controlled citrulline specificity. Overall, we have demonstrated a molecular mechanism that explains how ACPAs trigger arthritis.

-	~~Authors~~:	+	Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.,Ge C, Tong D, Liang B, Lonnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R JCI Insight. 2017 Jul 6;2(13). pii: 93688. doi: 10.1172/jci.insight.93688. PMID:28679953<ref>PMID:28679953</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mu0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Dobritzsch, D]]
		+	[[Category: Ge, C]]
		+	[[Category: Holmdahl, R]]
		+	[[Category: Immune system]]

OCA: Protected "5mu0" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 13:16:34 GMT

Protected "5mu0" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:16, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5mu0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 13:16:33 GMT

New page: '''Unreleased structure''' The entry 5mu0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mu0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]