5mu1 - Revision history

OCA at 07:40, 8 March 2023

OCA — Wed, 08 Mar 2023 07:40:10 GMT

←Older revision		Revision as of 07:40, 8 March 2023
Line 3:		Line 3:
	<StructureSection load='5mu1' size='340' side='right'caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>		<StructureSection load='5mu1' size='340' side='right'caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chatd Chatd~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD~~</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[3wzs\|3wzs]], [[3wzt\|3wzt]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [https://pdbe.org/5mu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [https://pdbe.org/5mu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G0SB58_CHATD G0SB58_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chatd~~]]	+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alonzi~~, D S~~]]	+	[[Category: Alonzi DS]]
-	[[Category: Caputo~~, A T~~]]	+	[[Category: Caputo AT]]
-	[[Category: Hill, J]]	+	[[Category: Hill J]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Zitzmann, N]]	+	[[Category: Zitzmann N]]
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Misfolding]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:23, 8 June 2021

OCA — Tue, 08 Jun 2021 15:23:51 GMT

←Older revision		Revision as of 15:23, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='5mu1' size='340' side='right'caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>		<StructureSection load='5mu1' size='340' side='right'caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=PT:~~PLATINUM+(II)+ION~~'>PT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wzs\|3wzs]], [[3wzt\|3wzt]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [~~http~~://pdbe.org/5mu1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [https://pdbe.org/5mu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:07, 8 April 2020

OCA — Wed, 08 Apr 2020 07:07:34 GMT

←Older revision		Revision as of 07:07, 8 April 2020
Line 1:		Line 1:

	==UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum soaked with K2PtI6==		==UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum soaked with K2PtI6==
-	<StructureSection load='5mu1' size='340' side='right' caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>	+	<StructureSection load='5mu1' size='340' side='right'caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [http://pdbe.org/5mu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [http://pdbe.org/5mu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Chatd]]		[[Category: Chatd]]
		+	[[Category: Large Structures]]
	[[Category: Alonzi, D S]]		[[Category: Alonzi, D S]]
	[[Category: Caputo, A T]]		[[Category: Caputo, A T]]

OCA at 01:22, 16 November 2017

OCA — Thu, 16 Nov 2017 01:22:20 GMT

←Older revision		Revision as of 01:22, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5mu1' size='340' side='right' caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>		<StructureSection load='5mu1' size='340' side='right' caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [http://pdbe.org/5mu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [http://pdbe.org/5mu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Alonzi, D S]]		[[Category: Alonzi, D S]]
	[[Category: Caputo, A T]]		[[Category: Caputo, A T]]

OCA at 04:11, 4 August 2017

OCA — Fri, 04 Aug 2017 04:11:00 GMT

←Older revision		Revision as of 04:11, 4 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mu1 is ~~ON HOLD until Paper~~ Publication	+	==UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum soaked with K2PtI6==
		+	<StructureSection load='5mu1' size='340' side='right' caption='[[5mu1]], [[Resolution\|resolution]] 3.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mu1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wzs\|3wzs]], [[3wzt\|3wzt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu1 OCA], [http://pdbe.org/5mu1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic reticulum (ER), where their folding is surveyed by the 170-kDa UDP-glucose:glycoprotein glucosyltransferase (UGGT). The enzyme acts as the single glycoprotein folding quality control checkpoint: it selectively reglucosylates misfolded glycoproteins, promotes their association with ER lectins and associated chaperones, and prevents premature secretion from the ER. UGGT has long resisted structural determination and sequence-based domain boundary prediction. Questions remain on how this single enzyme can flag misfolded glycoproteins of different sizes and shapes for ER retention and how it can span variable distances between the site of misfold and a glucose-accepting N-linked glycan on the same glycoprotein. Here, crystal structures of a full-length eukaryotic UGGT reveal four thioredoxin-like (TRXL) domains arranged in a long arc that terminates in two beta-sandwiches tightly clasping the glucosyltransferase domain. The fold of the molecule is topologically complex, with the first beta-sandwich and the fourth TRXL domain being encoded by nonconsecutive stretches of sequence. In addition to the crystal structures, a 15-A cryo-EM reconstruction reveals interdomain flexibility of the TRXL domains. Double cysteine point mutants that engineer extra interdomain disulfide bridges rigidify the UGGT structure and exhibit impaired activity. The intrinsic flexibility of the TRXL domains of UGGT may therefore endow the enzyme with the promiscuity needed to recognize and reglucosylate its many different substrates and/or enable reglucosylation of N-linked glycans situated at variable distances from the site of misfold.

-	~~Authors~~:	+	Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.,Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, Siliqi D, Vasiljevic S, Mohammed S, Lukacik P, Walsh MA, Santino A, Zitzmann N Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201703682. doi:, 10.1073/pnas.1703682114. PMID:28739903<ref>PMID:28739903</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mu1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alonzi, D S]]
		+	[[Category: Caputo, A T]]
		+	[[Category: Hill, J]]
		+	[[Category: Roversi, P]]
		+	[[Category: Zitzmann, N]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Misfolding]]
		+	[[Category: Transferase]]

OCA at 12:28, 22 March 2017

OCA — Wed, 22 Mar 2017 12:28:55 GMT

←Older revision		Revision as of 12:28, 22 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5mu1 is ON HOLD	+	The entry 5mu1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5mu1" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 13:16:37 GMT

Protected "5mu1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:16, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5mu1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Jan 2017 13:16:36 GMT

New page: '''Unreleased structure''' The entry 5mu1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mu1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]