5mue - Revision history

OCA at 17:50, 8 November 2023

OCA — Wed, 08 Nov 2023 17:50:17 GMT

←Older revision		Revision as of 17:50, 8 November 2023
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	==Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier==		==Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier==
-	<StructureSection load='5mue' size='340' side='right' caption='[[5mue]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5mue' size='340' side='right'caption='[[5mue]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mue]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MUE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.397Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTPA, TPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mue OCA], [~~http~~://pdbe.org/5mue PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mue RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mue PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mue ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mue OCA], [https://pdbe.org/5mue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mue RCSB], [https://www.ebi.ac.uk/pdbsum/5mue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mue ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN]] Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED) [MIM:[~~http~~://omim.org/entry/277460 277460]]. AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E.<ref>PMID:8602747</ref> <ref>PMID:9463307</ref> <ref>PMID:7719340</ref> <ref>PMID:7566022</ref> <ref>PMID:15065857</ref> <ref>PMID:15300460</ref>	+	[https://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN] Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED) [MIM:[https://omim.org/entry/277460 277460]. AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E.<ref>PMID:8602747</ref> <ref>PMID:9463307</ref> <ref>PMID:7719340</ref> <ref>PMID:7566022</ref> <ref>PMID:15065857</ref> <ref>PMID:15300460</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN]] Binds alpha-tocopherol and enhances its transfer between separate membranes.	+	[https://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN] Binds alpha-tocopherol and enhances its transfer between separate membranes.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Aeschimann, W~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Stocker, A~~]]	+	[[Category: Aeschimann W]]
-	[[Category: ~~Lipid transfer protein]]~~	+	[[Category: Stocker A]]
-	~~[[Category: Sec14-like]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:57, 5 December 2018

OCA — Wed, 05 Dec 2018 06:57:37 GMT

←Older revision		Revision as of 06:57, 5 December 2018
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	<StructureSection load='5mue' size='340' side='right' caption='[[5mue]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5mue' size='340' side='right' caption='[[5mue]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mue]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MUE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mue]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MUE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TTPA, TPP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mue OCA], [http://pdbe.org/5mue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mue RCSB], [http://www.ebi.ac.uk/pdbsum/5mue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mue ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mue OCA], [http://pdbe.org/5mue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mue RCSB], [http://www.ebi.ac.uk/pdbsum/5mue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mue ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Aeschimann, W]]		[[Category: Aeschimann, W]]
	[[Category: Stocker, A]]		[[Category: Stocker, A]]

OCA at 16:08, 20 October 2017

OCA — Fri, 20 Oct 2017 16:08:34 GMT

←Older revision		Revision as of 16:08, 20 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mue is ~~ON HOLD~~	+	==Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier==
		+	<StructureSection load='5mue' size='340' side='right' caption='[[5mue]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mue]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MUE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VIV:(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL'>VIV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mue OCA], [http://pdbe.org/5mue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mue RCSB], [http://www.ebi.ac.uk/pdbsum/5mue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mue ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN]] Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED) [MIM:[http://omim.org/entry/277460 277460]]. AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E.<ref>PMID:8602747</ref> <ref>PMID:9463307</ref> <ref>PMID:7719340</ref> <ref>PMID:7566022</ref> <ref>PMID:15065857</ref> <ref>PMID:15300460</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TTPA_HUMAN TTPA_HUMAN]] Binds alpha-tocopherol and enhances its transfer between separate membranes.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vitamin E is one of the most important natural antioxidants, protecting polyunsaturated fatty acids in the membranes of cells. Among different chemical isoforms assimilated from dietary regimes, RRR-alpha-tocopherol is the only one retained in higher animals. This is possible thanks to alpha-Tocopherol Transfer Protein (alpha-TTP), which extracts alpha-tocopherol from endosomal compartments in liver cells, facilitating its distribution into the body. Here we show that, upon binding to its substrate, alpha-TTP acquires tendency to aggregation into thermodynamically stable high molecular weight oligomers. Determination of the structure of such aggregates by X-ray crystallography revealed a spheroidal particle formed by 24 protein monomers. Oligomerization is triggered by refolding of the N-terminus. Experiments with cultured cell monolayers demonstrate that the same oligomers are efficiently transported through an endothelial barrier (HUVEC) and not through an epithelial one (Caco-2). Discovery of a human endogenous transport protein with intrinsic capability of crossing endothelial tissues opens to new ways of drug delivery into the brain or other tissues protected by endothelial barriers.

-	~~Authors: Stocker, A~~., Aeschimann, W.	+	Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.,Aeschimann W, Staats S, Kammer S, Olieric N, Jeckelmann JM, Fotiadis D, Netscher T, Rimbach G, Cascella M, Stocker A Sci Rep. 2017 Jul 10;7(1):4970. doi: 10.1038/s41598-017-05148-9. PMID:28694484<ref>PMID:28694484</ref>

-	~~Description: Self~~-~~assembled alpha~~-~~Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Stocker, A]]~~	+	<div class="pdbe-citations 5mue" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aeschimann, W]]		[[Category: Aeschimann, W]]
		+	[[Category: Stocker, A]]
		+	[[Category: Lipid transfer protein]]
		+	[[Category: Sec14-like]]
		+	[[Category: Transport protein]]

OCA at 11:39, 9 March 2017

OCA — Thu, 09 Mar 2017 11:39:58 GMT

←Older revision		Revision as of 11:39, 9 March 2017
Line 7:		Line 7:
	Description: Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier		Description: Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Aeschimann, W]]
	[[Category: Stocker, A]]		[[Category: Stocker, A]]
		+	[[Category: Aeschimann, W]]

OCA: Protected "5mue" [edit=sysop:move=sysop]

OCA — Wed, 18 Jan 2017 13:17:48 GMT

Protected "5mue" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:17, 18 January 2017

OCA: New page: '''Unreleased structure''' The entry 5mue is ON HOLD Authors: Stocker, A., Aeschimann, W. Description: Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E ...

OCA — Wed, 18 Jan 2017 13:17:46 GMT

New page: '''Unreleased structure''' The entry 5mue is ON HOLD Authors: Stocker, A., Aeschimann, W. Description: Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E ...

New page

'''Unreleased structure'''

The entry 5mue is ON HOLD

Authors: Stocker, A., Aeschimann, W.

Description: Self-assembled alpha-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier
[[Category: Unreleased Structures]]
[[Category: Aeschimann, W]]
[[Category: Stocker, A]]