5mx8 - Revision history

OCA at 17:52, 8 November 2023

OCA — Wed, 08 Nov 2023 17:52:52 GMT

←Older revision		Revision as of 17:52, 8 November 2023
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	<StructureSection load='5mx8' size='340' side='right'caption='[[5mx8]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5mx8' size='340' side='right'caption='[[5mx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mx8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MX8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MX8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=HPA:HYPOXANTHINE'>HPA</scene~~>, ~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5mx4\|5mx4]], [[5mx6\|5mx6]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx8 OCA], [https://pdbe.org/5mx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mx8 RCSB], [https://www.ebi.ac.uk/pdbsum/5mx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx8 OCA], [~~http~~://pdbe.org/5mx8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mx8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mx8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx8 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DEOD_HELPY DEOD_HELPY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]	+	*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Purine-nucleoside phosphorylase]]~~	+	[[Category: Stefanic Z]]
-	[[Category: Stefanic, Z]]	+
-	~~[[Category: Clinical isolate]]~~	+
-	~~[[Category: Dead-end-complex]]~~	+
-	~~[[Category: Purine nucleoside phosphorylase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:40, 16 October 2019

OCA — Wed, 16 Oct 2019 06:40:37 GMT

←Older revision		Revision as of 06:40, 16 October 2019
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	==Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3==		==Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3==
-	<StructureSection load='5mx8' size='340' side='right' caption='[[5mx8]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5mx8' size='340' side='right'caption='[[5mx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mx8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mx8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX8 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5mx8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5mx8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
		+	[[Category: Large Structures]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Stefanic, Z]]		[[Category: Stefanic, Z]]

OCA at 13:20, 5 April 2017

OCA — Wed, 05 Apr 2017 13:20:38 GMT

←Older revision		Revision as of 13:20, 5 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5mx8 is ~~ON HOLD~~	+	==Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3==
		+	<StructureSection load='5mx8' size='340' side='right' caption='[[5mx8]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mx8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5mx4\|5mx4]], [[5mx6\|5mx6]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx8 OCA], [http://pdbe.org/5mx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx8 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx8 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Microaerophilic bacterium Helicobacer pylori is a well known human pathogen involved in the development of many diseases. Due to the evergrowing infection rate and increase of H. pylori antibiotic resistence, it is of utmost importance to find a new way to attack and eradicate H. pylori. The purine metabolism in H. pylori is solely dependant on the salvage pathway and one of the key enzymes in this pathway is purine nucleoside phosphorylase (PNP). In this timely context, we report here the basic biochemical and structural characterization of recombinant PNP from the H. pylori clinical isolate expressed in Escherichia coli. Structure of H. pylori PNP is typical for high molecular mass PNPs. However, its activity towards adenosine is very low, thus resembling more that of low molecular mass PNPs. Understanding the molecular mechanism of this key enzyme may lead to the development of new drug strategies and help in the eradication of H. pylori.

-	~~Authors: Stefanic~~, Z.	+	Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori.,Stefanic Z, Mikleusevic G, Luic M, Bzowska A, Lescic Asler I Int J Biol Macromol. 2017 Mar 20;101:518-526. doi:, 10.1016/j.ijbiomac.2017.03.101. PMID:28336275<ref>PMID:28336275</ref>

-	~~Description: Crystal structure~~ of H. ~~pylori purine nucleoside phosphorylase from clinical isolate HpPNP~~-3	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mx8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Stefanic, Z]]		[[Category: Stefanic, Z]]
		+	[[Category: Clinical isolate]]
		+	[[Category: Dead-end-complex]]
		+	[[Category: Purine nucleoside phosphorylase]]
		+	[[Category: Transferase]]

OCA: Protected "5mx8" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2017 15:20:15 GMT

Protected "5mx8" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:20, 1 February 2017

OCA: New page: '''Unreleased structure''' The entry 5mx8 is ON HOLD Authors: Stefanic, Z. Description: Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3 [[C...

OCA — Wed, 01 Feb 2017 15:20:14 GMT

New page: '''Unreleased structure''' The entry 5mx8 is ON HOLD Authors: Stefanic, Z. Description: Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3 [[C...

New page

'''Unreleased structure'''

The entry 5mx8 is ON HOLD

Authors: Stefanic, Z.

Description: Crystal structure of H. pylori purine nucleoside phosphorylase from clinical isolate HpPNP-3
[[Category: Unreleased Structures]]
[[Category: Stefanic, Z]]