5mxq - Revision history

OCA at 17:53, 8 November 2023

OCA — Wed, 08 Nov 2023 17:53:17 GMT

←Older revision		Revision as of 17:53, 8 November 2023
Line 3:		Line 3:
	<StructureSection load='5mxq' size='340' side='right'caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5mxq' size='340' side='right'caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8K:3-(phenylsulfonylamino)pyridine-2-carboxylic+acid'>U8K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8K:3-(phenylsulfonylamino)pyridine-2-carboxylic+acid'>U8K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxq OCA], [~~http~~://pdbe.org/5mxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxq OCA], [https://pdbe.org/5mxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mxq RCSB], [https://www.ebi.ac.uk/pdbsum/5mxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9K2N0_PSEAI Q9K2N0_PSEAI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Benvenuti, M~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Docquier, J D~~]]	+	[[Category: Benvenuti M]]
-	[[Category: Luca, F ~~De]]~~	+	[[Category: De Luca F]]
-	~~[[Category: Mangani, S~~]]	+	[[Category: Di Pisa F]]
-	[[Category: Pisa, F Di]]	+	[[Category: Docquier JD]]
-	[[Category: ~~Pozzi, C~~]]	+	[[Category: Mangani S]]
-	[[Category: ~~Alpha-beta-beta-alpha sandwich~~]]	+	[[Category: Pozzi C]]
-	[[Category: ~~Hydrolase]]~~	+
-	~~[[Category: Metallo-beta-lactamase fold]]~~	+
-	~~[[Category: Metallo-beta-lactamase inhibitor]]~~	+
-	~~[[Category: Pfam00753]]~~	+
-	~~[[Category: Zinc-dependent hydrolase~~]]	+

OCA at 07:38, 24 April 2019

OCA — Wed, 24 Apr 2019 07:38:23 GMT

←Older revision		Revision as of 07:38, 24 April 2019
Line 1:		Line 1:

	==Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-90 Inhibitor==		==Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-90 Inhibitor==
-	<StructureSection load='5mxq' size='340' side='right' caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5mxq' size='340' side='right'caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Benvenuti, M]]		[[Category: Benvenuti, M]]
	[[Category: Docquier, J D]]		[[Category: Docquier, J D]]

OCA at 06:57, 5 December 2018

OCA — Wed, 05 Dec 2018 06:57:47 GMT

←Older revision		Revision as of 06:57, 5 December 2018
Line 3:		Line 3:
	<StructureSection load='5mxq' size='340' side='right' caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5mxq' size='340' side='right' caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8K:3-(phenylsulfonylamino)pyridine-2-carboxylic+acid'>U8K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8K:3-(phenylsulfonylamino)pyridine-2-carboxylic+acid'>U8K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaVIM-2, bla vim-2, bla-VIM-2, blasVIM-2, blaVIM2, blm, VIM-2, vim-2, PAERUG_P32_London_17_VIM_2_10_11_06255 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxq OCA], [http://pdbe.org/5mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxq RCSB], [http://www.ebi.ac.uk/pdbsum/5mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxq OCA], [http://pdbe.org/5mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxq RCSB], [http://www.ebi.ac.uk/pdbsum/5mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-beta-lactamase (MBL) and serine-beta-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new beta-lactamase inhibitors to be used in conjunction with carbapenems and other beta-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-beta-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.
		+
		+	SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.,Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT ACS Infect Dis. 2018 Nov 30. doi: 10.1021/acsinfecdis.8b00246. PMID:30427656<ref>PMID:30427656</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mxq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:14, 28 February 2018

OCA — Wed, 28 Feb 2018 06:14:05 GMT

←Older revision		Revision as of 06:14, 28 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mxq is ~~ON HOLD~~	+	==Crystal Structure of the Acquired VIM-2 Metallo-beta-Lactamase in Complex with ANT-90 Inhibitor==
-		+	<StructureSection load='5mxq' size='340' side='right' caption='[[5mxq]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mxq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MXQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=U8K:3-(phenylsulfonylamino)pyridine-2-carboxylic+acid'>U8K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxq OCA], [http://pdbe.org/5mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxq RCSB], [http://www.ebi.ac.uk/pdbsum/5mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxq ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Benvenuti, M]]
		+	[[Category: Docquier, J D]]
		+	[[Category: Luca, F De]]
		+	[[Category: Mangani, S]]
		+	[[Category: Pisa, F Di]]
		+	[[Category: Pozzi, C]]
		+	[[Category: Alpha-beta-beta-alpha sandwich]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metallo-beta-lactamase fold]]
		+	[[Category: Metallo-beta-lactamase inhibitor]]
		+	[[Category: Pfam00753]]
		+	[[Category: Zinc-dependent hydrolase]]

OCA: Protected "5mxq" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2017 15:22:07 GMT

Protected "5mxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:22, 1 February 2017

OCA: New page: '''Unreleased structure''' The entry 5mxq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Feb 2017 15:22:06 GMT

New page: '''Unreleased structure''' The entry 5mxq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mxq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]